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45 Body composition as a predictive and prognostic biomarker in advanced urothelial carcinoma (UC) patients treated with immune checkpoint inhibitors (ICI)
Dylan Martini, Julie Shabto, Subir Goyal, Yuan Liu, T Anders Olsen, Sean Evans, Benjamin Magod, Deepak Ravindranathan, Jacqueline Brown, Lauren Yantorni, Greta Russler, Sarah Caulfield, Jamie Goldman, Bassel Nazha, Shreyas Joshi, Haydn Kissick, Kenneth Ogan, Wayne Harris, Omer Kucuk, Bradley Carthon, Viraj Master, Mehmet Bilen

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A27-A29; DOI: 10.1136/jitc-2020-SITC2020.0045
444 MHC-I skewing in mutant calreticulin-positive myeloproliferative neoplasms is countered by heteroclitic peptide cancer vaccination
Mathieu Gigoux, Roberta Zappasodi, Joseph Park, Stephane Pourpe, Arnab Ghosh, Cansu Cimen Bozkus, Levi Mangarin, David Redmond, Svena Verma, Sara Schad, William Duke, Max Jan, Matthew Leventhal, Vincent Ho, Gabriela Hobbs, Trine Alma Knudsen, Vibe Skov, Lasse Kjær, Thomas Stauffer Larsen, Dennis Lund Hansen, R Coleman Lindsley, Hans Hasselbalch, Jacob Grauslund, Mads Andersen, Morten Holmström, Timothy Chan, Raajit Rampal, Omar Abdel-Wahab, Nina Bhardwaj, Jedd Wolchok, Ann Mullally, Taha Merghoub

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A270; DOI: 10.1136/jitc-2020-SITC2020.0444
445 Blockade of the inhibitory collagen receptor LAIR-1 with NC410, a LAIR2-Fc fusion protein, enhances anti-tumor activity of the bifunctional fusion protein bintrafusp alfa
Lucas Horn, Linjie Tian, Dallas Flies, Linda Liu, Solomon Langermann, Jeffrey Schlom, Claudia Palena

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A270-A271; DOI: 10.1136/jitc-2020-SITC2020.0445
446 Immunopeptidome changes mediated by a novel ERAP1 inhibitor leads to tumor growth inhibition
Peter Joyce, Lesley Young, Martin Quibell, Jason Shiers, Carmen Tong, Kristopher Clark, Edd James, Emma Reeves, Alihussein Remtulla, Henry Leonard, Camila de Almeida, Elisa Lori, Nicola Ternette, Fergus Poynton, Andrew Leishman

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A271; DOI: 10.1136/jitc-2020-SITC2020.0446
449 Neoadjuvant cyclic dinucleotides combined with interleukin-2 and anti-PD-1 antibody limit lung metastasis of orthotopic breast tumors through prolonged NK cell activation
Lauren Milling, Darrell Irvine

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A272-A273; DOI: 10.1136/jitc-2020-SITC2020.0449
450 Combination of rhIL-7-hyFc and anti-PD-L1xCD3ε bispecific antibody enhances antitumor response in mice
Sujeong Park, Ji-Hae Kim, Yeon-Woo Kang, Kun-Joo Lee, Dain Moon, Nara Tae, Yunji Park, Dae Hee Kim, Byung Ha Lee, Donghoon Choi, Se Hwan Yang, Seung-Woo Lee

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A273-A274; DOI: 10.1136/jitc-2020-SITC2020.0450
454 Oncolytic parainfluenza virus 5 vector enhances natural killer cell killing of lung tumor cells in 2D and 3D spheroid cultures
Namita Varudkar, Jeremiah Oyer, Alicja Copik, Griffith Parks

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A276; DOI: 10.1136/jitc-2020-SITC2020.0454
455 Impact of EphB4 and PD-1 treatment on immune infiltrate in advanced bladder cancer
Sarmad Sadeghi, Tyler Hether, Jason Yeon, Richard Mangio, Jason Reeves, Yan Liang, Sarah Warren, Troy McEachron, Parkash Gill

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A276; DOI: 10.1136/jitc-2020-SITC2020.0455
456 Impact of angiotensin II pathway inhibition on tumor response to anti PD(L)1 based therapy
Julius Strauss, Ravi Madan, Marijo Bilusic, Fatima Karzai, Scot Niglio, Jason Redman, Houssein Abdul Sater, Charalampos Floudas, Jung-Min Lee, Andrea Apolo, Seth Steinberg, Jeffrey Schlom, James Gulley

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A276-A277; DOI: 10.1136/jitc-2020-SITC2020.0456
457 Intratumoral interleukin-12 administered after cryoablation does not improve survival in multiple bilateral murine models
Maura Vrabel, Jake Schulman, David Zaharoff

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A277-A278; DOI: 10.1136/jitc-2020-SITC2020.0457

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