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249 Targeting IFNβ-regulated secretory profiles to overcome acquired anti-PD-L1 resistance
Yuhao Shi, Melissa Dolan, Michalis Mastri, Kevin Eng, John Ebos

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A150; DOI: 10.1136/jitc-2020-SITC2020.0249
253 Anti-TIGIT antibodies require enhanced FcγR co-engagement for optimal T and NK cell-dependent anti-tumor immunity
Rebecca Ward, Elena Paltrinieri, Marilyn Marques, Priyadarshini Iyer, Sylvia Dietrich, Jeremy Waight, Mark Bushell, Nicholas Wilson, Jennifer Buell, David Savitsky, Dhan Chand

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A153; DOI: 10.1136/jitc-2020-SITC2020.0253
255 Efficacy of sequential immune checkpoint inhibition (ICI) in patients with genitourinary malignancies
Sean Evans, Dylan Martini, Benjamin Magod, Timothy Olsen, Jacqueline Brown, Lauren Yantorni, Deepak Ravindranathan, Greta Russler, Sarah Caulfield, Jamie Goldman, Bassel Nazha, Wayne Harris, Viraj Master, Omer Kucuk, Bradley Carthon, Mehmet Bilen

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A154-A155; DOI: 10.1136/jitc-2020-SITC2020.0255
257 Development of a diagnostic platform which matches therapies to the tumor microenvironment dominant biology
Kristen Strand-Tibbitts

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A155-A156; DOI: 10.1136/jitc-2020-SITC2020.0257
256 Single-agent zalifrelimab (anti-CTLA-4) shows clinical benefit in rare tumors – case report from phase 2 study (NCT03104699)
Cesar Perez, Robert Wesolowski, Breelyn Wilky, Waldo Ortuzar Feliu, Hong Zhang, Irina Shapiro, Anna Wijatyk, Remigiusz Kaleta, Jonathan Trent

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A155; DOI: 10.1136/jitc-2020-SITC2020.0256
259 Phase Ib/II open-label, randomized evaluation of atezolizumab (atezo) + selicrelumab (seli) + gemcitabine+nab-paclitaxel (gem+nabP) or bevacizumab (bev) vs control in MORPHEUS-PDAC, -TNBC and -CRC
Gulam Manji, Nathan Bahary, Vincent Chung, Florence Dalenc, Michel Ducreux, Carlos Gomez-Roca, Seock-Ah Im, Jeremy Kortmansky, Jill Lacy, Neil Segal, Olivier Tredan, Olivera Cirovic, Kelly DuPree, Christelle Lenain, Danny Lu, Lidia Robert, Jeffrey Xu, Xiaosong Zhang, Sung-Bae Kim

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A157-A158; DOI: 10.1136/jitc-2020-SITC2020.0259
260 T cell infiltrating repertoire diversity is associated with enhanced survival following neoadjuvant therapy in patients with resectable pancreatic cancer
Pranav Murthy, Pragosh Saini, Kira Russell, Wenjing Pan, Daniel Weber, Miranda Byrne-Steele, Jian Han, Viginia Espina, Lance Liotta, Herbert Zeh, Nathan Bahary, Aatur Singhi, Tullia Bruno, Amer Zureikat, Michael Lotze

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A158-A159; DOI: 10.1136/jitc-2020-SITC2020.0260
265 Phase 1b study of avelumab + M9241 (NHS-IL12) in patients with advanced solid tumors: interim analysis results from a urothelial carcinoma (UC) dose-expansion cohort
Jean-Laurent Deville, Alain Ravaud, Marco Maruzzo, Theodore Gourdin, Michele Maio, Luc Dirix, XiaoZhe Wang, Yulia Vugmeyster, Frank Beier, Jeorg Seebeck, Sarah Chennoufi, James Gulley

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A163; DOI: 10.1136/jitc-2020-SITC2020.0265
274 Tumoral and peripheral immunophenotype of refractory vs relapse to PD-(L)1 blockade in patients with advanced non-small cell lung cancer
Maria Ascierto, Matthew Hellmann, Nathan Standifer, Song Wu, Han Si, Chris Morehouse, Marlon Rebelatto, Shaad Abdullah, Rajiv Raja, Jean-Charles Soria, Caroline Germa, Carl Barrett

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A167; DOI: 10.1136/jitc-2020-SITC2020.0274
276 Prognostic value of tumor size varies by treatment in a meta-analysis of 15 randomized clinical trials in advanced non-small cell lung cancer across immunotherapy, TKI, and chemotherapy regimens
Jacqueline Buros, Krzysztof Sakrejda, Daniel Lee, Eric Novik, Philip Jewsbury

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A168-A169; DOI: 10.1136/jitc-2020-SITC2020.0276

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