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325 Immunotherapy with B cell activating antibody CPI-006 in patients (pts) with mild to moderate COVID-19 stimulates anti-SARS-CoV-2 antibody response, memory B cells and memory T effector cells
Gerard Criner, Mehrdad Mobasher, Craig Hill, Shenshen Hu, Suresh Mahabhashyam, Joshua Brody, Thomas Marron, Stephen Willingham, Richard Miller

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A199-A200; DOI: 10.1136/jitc-2020-SITC2020.0325
326 SARS-CoV-2 specific T-cells in TIL from patients with epithelial cancer
Pedro Noronha, Georgia Paraschoudi, Eric Sousa, Jéssica Kamiki, Patrícia António, Carolina Condenço, Inês Silva, Andreia Maia, Mireia Castillo-Martin, António Beltran, Carlos Carvalho, Joana Lerias, Alimuddin Zumla, Markus Maeurer

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A200; DOI: 10.1136/jitc-2020-SITC2020.0326
330 Investigating the clinical safety, efficacy, and immune modulation of combined XL888 and pembrolizumab in metastatic gastrointestinal malignancies
Cameron Herting, Yuchen Zhang, Deon Doxie, Matthew Farren, Michael Ware, Olatunji Alese, Christina Wu, Walid Shaib, Mehmet Akce, Mohammad Zaidi, Amanda Ruggieri, Madhav Dhodapkar, Kavita Dhodapkar, Juan Sarmiento, Rafi Ahmed, Shishir Maithel, Bassel El-rayes, Gregory Lesinski

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A202-A203; DOI: 10.1136/jitc-2020-SITC2020.0330
331 Immunotherapy with Y90-radioembolization for metastatic colorectal cancer (iRE-C)
Pashtoon Kasi, Beau Toskich, Sandeep Laroia

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A203; DOI: 10.1136/jitc-2020-SITC2020.0331
332 Novel TGF-β signatures in metastatic colorectal cancer patients treated with vactosertib in combination with pembrolizumab
Keun-Wook Lee, Young Suk Park, Joong Bae Ahn, Jin Kyung Lee, Jiyeon Ryu, Bitna Oh, Chan-Young Ock, Sunjin Hwang, Ki Baik Hahm, Seong-Jin Kim, Tae Won Kim

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A203-A204; DOI: 10.1136/jitc-2020-SITC2020.0332
333 Targeting the apical intracellular checkpoint CISH unleashes T cell neoantigen reactivity and effector program
Douglas Palmer, Beau Webber, Yogin Patel, Matthew Johnson, Christine Kariya, Walker Lahr, Maria Parkhurst, Jared Gartner, Todd Prickett, Frank Lowery, Rigel Kishton, Devikala Gurusamy, Zulmarie Franco, Suman Vodnala, Miechaleen Diers, Natalie Wolf, Nicholas Slipek, David McKenna, Darin Sumstad, Lydia Viney, Tom Henley, Tilmann Bürckstümmer, Oliver Baker, Ying Hu, Chunhua Yan, Daoud Meerzaman, Kartik Padhan, Winnie Lo, Parisa Malekzadeh, Li Jia, Drew Deniger, Shashank Patel, Paul Robbins, R Scott McIvor, Modassir Choudhry, Steven Rosenberg, Branden Moriarity, Nicholas Restifo

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A204; DOI: 10.1136/jitc-2020-SITC2020.0333
337 Pembrolizumab in combination with xelox bevacizumab in patients with microsatellite stable (MSS) metastatic colorectal cancer and a high immune infiltrate: a proof of concept study. FFCD 1703 POCHI
David Tougeron, Jean Francois Emile, Stephano Kim, Carole Monterymard, Marine Gilabert, BEZ Jérémie, Astrid Lievre, Laetitia Dahan, Pierre Laurent-puig, Laurent Mineur, ROmain Coriat, Jean Louis Legoux, Vincent Hautefeuille, Jean marc Phelip, Thierry Lecomte, Harry Sokol, Claude Capron, Claire Gallois, Violaine Randrian, Come Lepage, Julien Taieb

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A206; DOI: 10.1136/jitc-2020-SITC2020.0337
341 Phase 1b/2 study of BXCL701, an oral activator of the systemic innate immunity pathway, combined with pembrolizumab (pembro), in men with metastatic castration-resistant prostate cancer (mCRPC)
Rahul Aggarwal, Dan Costin, Jingsong Zhang, Paul Monk, Mark Linch, Lawrence Karsh, Diane Healey, Stefani Corsi-Travali, Sreenivas Adurthi, Adedayo Adedoyin, Vincent O’Neill

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A208-A209; DOI: 10.1136/jitc-2020-SITC2020.0341
343 Phase 3 study of pembrolizumab + docetaxel and prednisone/prednisolone for metastatic castration-resistant prostate cancer (mCRPC) pretreated with next-generation hormonal agents (NHAs) (KEYNOTE-921)
Daniel Petrylak, Neal Shore, Mostefa Bennamoun, Raffaele Ratta, Josep Piulats, Ben Li, Charles Schloss, Karim Fizazi

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A209-A210; DOI: 10.1136/jitc-2020-SITC2020.0343
36 Molecular events regulating solid tumor cell responses to natural killer cells
Michal Sheffer, Constantine Mitsiades

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A21-A22; DOI: 10.1136/jitc-2020-SITC2020.0036

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