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44 Corticosteroids decrease efficacy of immune checkpoint inhibitor therapy and correlate with compromised CD8+ T-cell differentiation in patients with non-small cell lung cancer
Lauren Polyakov, Takaaki Oba, Hongbin Chen, Eihab Abdelfatah, Joy Sarkar, Kristopher Attwood, Rajeev Sharma, Brahm Segal, Grace Dy, Fumito Ito

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A51; DOI: 10.1136/jitc-2023-SITC2023.0044
45 An integrative immune signature of complementary circulating and tumoral biomarkers maximizes the predictive power of adjuvant immunotherapeutic benefits for high-risk melanoma
Ahmad A Tarhini, Alyssa Obermayer, Sandra J Lee, William A LaFramboise, F Stephen Hodi, Arivarasan D Karunamurthy, Patrick Hwu, Dung-tsa Chen, Issam El Naqa, Howard Streicher, Walter J Storkus, Lisa H Butterfield, John M Kirkwood, Timothy I Shaw

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A52; DOI: 10.1136/jitc-2023-SITC2023.0045
46 Efficacy of atezolizumab and docetaxel in patients with HER2-positive non-small cell lung cancer: a pooled post hoc of the OAK and POPLAR trials
Junzhu Xu, Benjamin Frey, Hu Ma, Udo Gaipl, Jian-Guo Zhou

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A53; DOI: 10.1136/jitc-2023-SITC2023.0046
47 Baseline blood DNA methylation-based immune profiles and tumor mutational burden predict survival outcomes in anti-PD-1 treated head and neck cancer patient
Ze Zhang, Kartik Sehgal, Keisuke Shirai, Rondi Butler, John Wiencke, Devin Koestler, Geat Ramush, Min Kyung Lee, Annette Molinaro, Hannah Stolrow, Lucas A Salas, Robert Haddad, Karl Kelsey, Brock Christensen

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A54-A56; DOI: 10.1136/jitc-2023-SITC2023.0047
48 Blood-based peripheral T cell cytotoxicity assay in predicting response to immune checkpoint inhibitors: a US pilot study
Rajesh Nair, Jonathon Woo, Suzanna Lee, Shumei Kato, Michele Baltay, Yali Li, Kota Iwahori, Junichi Akatsuka, Srinath Sampath, Christian Schmedt, Srihari Sampath

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A57; DOI: 10.1136/jitc-2023-SITC2023.0048
49 High efficient circulating tumor cells (CTCs) mutation detection in cancer patients using targeted panel sequencing
Robbie Huff, Dylan Dufek, Stephenie Jones, Janet Dickerson, Yipeng Wang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A58; DOI: 10.1136/jitc-2023-SITC2023.0049
50 External inter-laboratory reproducibility of PD-L1 IHC 22C3 pharmDx (SK006) for biliary tract adenocarcinoma at CPS ≥ 1 and CPS ≥ 10
Gregory Cherryholmes, Deanna Moquin, Siena Tabuena-Frolli, Kristopher Kersch, Monika Polewski

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A59; DOI: 10.1136/jitc-2023-SITC2023.0050
6 Interrogation of spatial transcriptomics on canine tumor and normal tissue
Sarah Church, Ben Sutton, Erin Piazza, Kyla Teplitz

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A6; DOI: 10.1136/jitc-2023-SITC2023.0006
51 Tissue-based spatial analysis of DLBCL tumor microenvironment using multiplex immunofluorescence AQUA® (Automated Quantitative Analyses) algorithms
Jaspreet Kaur, Lisa Adams, Jimmie Lim, Sophia Kekchidou, Xun Li, Sarah Choi, Jennifer Bordeaux

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A60; DOI: 10.1136/jitc-2023-SITC2023.0051
52 Understanding cetuximab response and immune modulation in colorectal cancer using patient-derived organotypic tumor spheroids
Ketki Bhise, Chunxiao (Emma) Cui, Kirti Khardenavis, Anthony Attardo, Danielle Hagee, Sinal Patel, Julia Vail, Amir Aref, Nicholas Barris, Aaron Goldman, Alyssa Martin, Michael A Perricone

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A61; DOI: 10.1136/jitc-2023-SITC2023.0052

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