Open access

149 Simultaneous identification of KRAS mutation-carrying multiple neoepitopes by differential ion mobility-assisted targeted-mass spectrometry
Yuriko Minegishi, Noriko Iwamoto, Takashi Shimada, Kazuma Kiyotani, Satoshi Nagayama, Eric Tran, Yoshinobu Koguchi, William L Redmond, Brian Piening, Bernard A Fox, Koji Ueda

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A169; DOI: 10.1136/jitc-2023-SITC2023.0149
150 Class I and II neoantigen mapping in MSI-high colorectal cancer in needle biopsy size tissue samples
Ilja E Shapiro, Luca Raess, Marco Tognetti, Tikira Temu, Oliver M Bernhardt, Roland Bruderer, Yuehan Feng, Jonathan Woodsmith, Lukas Reiter

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A170; DOI: 10.1136/jitc-2023-SITC2023.0150
151 Genetic heterogeneity between paired primary and metastatic solid tumors and implications for neoantigen-based personalized cancer vaccines
Timothy I Shaw, Darwin Chang, Alyssa Obermayer, Jamie Teer, Xiaoqing Yu, Xuefeng Wang, Dale Hedges, Aik Choon Tan, Abdul Rafeh Naqash, Margaret E Gatti-Mays, Aakrosh Ratan, Martin D McCarter, John Carpten, Howard Colman, Igor Puzanov, Susanne M Arnold, Michelle Churchman, Patrick Hwu, William Dalton, George J Weiner, Jose Conejo-Garcia, Paulo C Rodriguez, Ahmad A Tarhini

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A171; DOI: 10.1136/jitc-2023-SITC2023.0151
152 Immuno-oncology protein biomarker panels provide greater biological insights and improved patient stratification
Marijana Rucevic, Arnav Mehta, Katarina Horneaus, Emmett Sprecher, Alexis Schneider, Russell W Jenkins, William Michaud, Benchun Miao, Ryan Sullivan, Keith Flaherty, Nir Hacohen, Genevieve M Boland

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A172; DOI: 10.1136/jitc-2023-SITC2023.0152
153 High expression of tertiary lymphoid structure gene signatures is associated with improved survival in head and neck squamous cell carcinoma patients treated with immune checkpoint blockade
Merzu Belete, Meijian Guan, Han Si, Brandon Higgs, Sriram Sridhar

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A173; DOI: 10.1136/jitc-2023-SITC2023.0153
154 Universal synthetic spike-in controls for accurate adaptive immune receptor profiling
Alex Chenchik, Tianbing Liu, Mikhail Makhanov, Dongfang Hu, Paul Diehl

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A174; DOI: 10.1136/jitc-2023-SITC2023.0154
155 Evaluation of in silico tools and chat-GPT to determine the impact of missense variants of immune-related genes associated with immunotherapy outcomes for solid tumors
Yoonhee Choi, Chan Mi Jung, Grace Kang, Peter Haseok Kim, Lena Chae, Pedro Hermida de Viveiros

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A175; DOI: 10.1136/jitc-2023-SITC2023.0155
156 Spatial transcriptomic signatures of the fundamentals of immuno-oncology
Patrick Danaher, Emily Killingbeck, Yan Liang, Megan Vandenberg, Sarah Church, Joseph Beechem, Sangsoon Woo

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A176; DOI: 10.1136/jitc-2023-SITC2023.0156
157 A transcriptomics-based response predictor identifies potential responders among patients with negative standard markers for response to immune checkpoint blockers
Gal Dinstag, Efrat Elis, Doreen S Ben-Zvi, Kenneth Aldape, Eytan Ruppin, Tuvik Beker, Raanan Berger, Ranit Aharonov

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A177; DOI: 10.1136/jitc-2023-SITC2023.0157
158 Interrogating real world tumor-infiltrating T-cell repertoires to identify antigen enriched TCRs in a large pan-cancer clinical cohort
Paul Fields, Fu Luo, Taylor Harding, Michelle M Stein, Catherine Igartua, Justin Guinney

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A178; DOI: 10.1136/jitc-2023-SITC2023.0158

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