Open access

128 staRgate: a flexible density-based automated gating pipeline for complex high-dimensional flow cytometry data
Jasme Lee, Matthew Adamow, Colleen Maher, Xiyu Peng, Phillip Wong, Fiona Ehrich, Margaret K Callahan, Ronglai Shen, Katherine S Panageas

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A144-A145; DOI: 10.1136/jitc-2023-SITC2023.0128
129 Modeling versatile three-dimensional patient-derived tumoroid (PDT) drug testing platforms by recapitulating tumor microenvironment oxygenation and immunocompetence
Huckie Del Mundo, Damieanus Ochola, Bhuvanesh Dave, Preethi Samuel

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A146-A147; DOI: 10.1136/jitc-2023-SITC2023.0129
130 Understanding tumor-immune-drug interaction through the effect of HSP90 inhibitor on immunocompetent human uterine adenosarcoma patient-derived tumoroids under variable oxygenation conditions
Huckie Del Mundo, Damieanus Ochola, Bhuvanesh Dave, Preethi Samuel

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A148; DOI: 10.1136/jitc-2023-SITC2023.0130
131 Evaluating the presence and temporal distribution of immune components in matrigel-based sarcoma and gallbladder cancer patient derived tumoroids (PDTs) that have intact tumor microenvironment
Damieanus Ochola, Huckie Del Mundo, Bhuvanesh Dave, Preethi Samuel

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A149-A151; DOI: 10.1136/jitc-2023-SITC2023.0131
132 A quantitative mass spectrometry workflow for highly multiplexed measurement of immunomodulatory proteins to support immunotherapy clinical trials
Ons Ousji, Anne Jang, Luca Genovesi, Nicholas Dupuis, Timon Geib, Gwenael Pottiez, Michael Schirm

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A152; DOI: 10.1136/jitc-2023-SITC2023.0132
133 The 31-gene expression profile test stratifies recurrence-free and melanoma-specific survival in patients with stage IB-IIA and stage IIB cutaneous melanoma
Robert W Cook, Sonia K Morgan-Linnell, Brian J Martin, Christine N Bailey, Abel Jarell

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A153; DOI: 10.1136/jitc-2023-SITC2023.0133
135 Integration of T-cell activation and tumor mutation burden predicts anti-PD-1 response
Fiona Ehrich, Matthew Adamow, Colleen Maher, Jasme Lee, Xiyu Peng, James W Smithy, Samuel A Funt, Michael Postow, Niamh Keegan, Katherine S Panageas, Ronglai Shen, Margaret K Callahan

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A155; DOI: 10.1136/jitc-2023-SITC2023.0135
136 Neoantigen-specific CD8 T cell responses constrain cutaneous squamous cell carcinoma
Anngela C Adams, Anne M Macy, Elizabeth S Borden, Lauren M Herrmann, Kenneth H Buetow, Melissa A Wilson, Denise J Roe, Karen Taraszka Hastings

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A156; DOI: 10.1136/jitc-2023-SITC2023.0136
137 Majority of mutations in cutaneous squamous cell carcinoma are unique to individual tumors
Elizabeth S Borden, Anngela C Adams, Anne M Macy, Tiffany Y Juan, Denise J Roe, Kenneth H Buetow, Melissa A Wilson, Karen Taraszka Hastings

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A157; DOI: 10.1136/jitc-2023-SITC2023.0137
138 Shared frameshift neoantigens are expressed throughout mismatch repair deficient cancer development and are recognized by tissue infiltrating T cells that are dysregulated in advanced lesions
Matthew Brown, Leandra Velazquez, Mesude Bicak, Juhana Habib, Sharonne Holtzman, Mona Saleh, Alexandros D Polydorides, Cansu Cimen Bozkus, Aimee L Lucas, Robert Samstein, Nina Bhardwaj

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A158; DOI: 10.1136/jitc-2023-SITC2023.0138

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