Basic Tumor Immunology

Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors
Deborah Ayeni, Braden Miller, Alexandra Kuhlmann, Ping-Chih Ho, Camila Robles-Oteiza, Mmaserame Gaefele, Stellar Levy, Fernando J. de Miguel, Curtis Perry, Tianxia Guan, Gerald Krystal, William Lockwood, Daniel Zelterman, Robert Homer, Zongzhi Liu, Susan Kaech, Katerina Politi

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 172; DOI: 10.1186/s40425-019-0643-8
α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas
E. Dodagatta-Marri, D. S. Meyer, M. Q. Reeves, R. Paniagua, M. D. To, M. Binnewies, M. L. Broz, H. Mori, D. Wu, M. Adoumie, R. Del Rosario, O. Li, T. Buchmann, B. Liang, J. Malato, F. Arce Vargus, D. Sheppard, B. C. Hann, A. Mirza, S. A. Quezada, M. D. Rosenblum, M. F. Krummel, A. Balmain, R. J. Akhurst

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 62; DOI: 10.1186/s40425-018-0493-9
Tumor-released autophagosomes induces CD4⁺ T cell-mediated immunosuppression via a TLR2–IL-6 cascade
Yong-Qiang Chen, Peng-Cheng Li, Ning Pan, Rong Gao, Zhi-Fa Wen, Tian-Yu Zhang, Fang Huang, Fang-Yuan Wu, Xi-Long Ou, Jin-Ping Zhang, Xue-Jun Zhu, Hong-Ming Hu, Kang Chen, Yun-Lang Cai, Li-Xin Wang

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 178; DOI: 10.1186/s40425-019-0646-5
High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status
Kim E. Kortekaas, Saskia J. Santegoets, Ziena Abdulrahman, Vanessa J. van Ham, Marij van der Tol, Ilina Ehsan, Helena C. van Doorn, Tjalling Bosse, Mariëtte I. E. van Poelgeest, Sjoerd H. van der Burg

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 236; DOI: 10.1186/s40425-019-0712-z
Long-term survival without graft-versus-host-disease following infusion of allogeneic myeloma-specific Vβ T cell families
S. Yado, G. Luboshits, O. Hazan, R. Or, M. A. Firer

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 301; DOI: 10.1186/s40425-019-0776-9
EnanDIM - a novel family of L-nucleotide-protected TLR9 agonists for cancer immunotherapy
Kerstin Kapp, Barbara Volz, Michael A. Curran, Detlef Oswald, Burghardt Wittig, Manuel Schmidt

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 5; DOI: 10.1186/s40425-018-0470-3
Collagen density regulates the activity of tumor-infiltrating T cells
Dorota E. Kuczek, Anne Mette H. Larsen, Marie-Louise Thorseth, Marco Carretta, Adrija Kalvisa, Majken S. Siersbæk, Ana Micaela C. Simões, Anne Roslind, Lars H. Engelholm, Elfriede Noessner, Marco Donia, Inge Marie Svane, Per thor Straten, Lars Grøntved, Daniel H. Madsen

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 68; DOI: 10.1186/s40425-019-0556-6
Molecular and metabolic pathways mediating curative treatment of a non-Hodgkin B cell lymphoma by Sindbis viral vectors and anti-4-1BB monoclonal antibody
Minjun Yu, Iris Scherwitzl, Silvana Opp, Aristotelis Tsirigos, Daniel Meruelo

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 185; DOI: 10.1186/s40425-019-0664-3
Carboxyamidotriazole combined with IDO1-Kyn-AhR pathway inhibitors profoundly enhances cancer immunotherapy
Jing Shi, Chen Chen, Rui Ju, Qingzhu Wang, Juan Li, Lei Guo, Caiying Ye, Dechang Zhang

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 246; DOI: 10.1186/s40425-019-0725-7
Mechanisms regulating PD-L1 expression on tumor and immune cells
Shuming Chen, George A. Crabill, Theresa S. Pritchard, Tracee L. McMiller, Ping Wei, Drew M. Pardoll, Fan Pan, Suzanne L. Topalian

Journal for ImmunoTherapy of Cancer Dec 2019, 7 (1) 305; DOI: 10.1186/s40425-019-0770-2

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