- Diffusion-Weighted Imaging Reveals Impaired Glymphatic Clearance in Idiopathic Intracranial Hypertension
The diffusivity along the cerebral perivascular spaces (DTI-ALPS technique) and lateral association and projection fibers in patients with IIH were compared with normal controls. Using the degree of diffusivity as a surrogate for glymphatic function, IIH patients were shown to have a significantly lower glymphatic clearance compared with controls (P=.005), with a significant association between declining glymphatic clearance and increasing Frisen papilledema grade (P=.046).
