- Cerebral Blood Flow Improvement after Indirect Revascularization for Pediatric Moyamoya Disease: A Statistical Analysis of Arterial Spin-Labeling MRI
The authors evaluated 15 children treated by indirect cerebral revascularization with multiple burr-holes between 2011–2013. Arterial spin-labeling MR imaging and T1 sequences were analyzed under SPM8 before and after the operation (3 and 12 months). Group analysis showed statistically significant preoperative hypoperfusion in the MCA territory in the Moyamoya hemispheres and a significant increase of cerebral perfusion in the same territory after revascularization. The authors conclude that SPM analysis of arterial spin-labeling MR imaging offers a noninvasive evaluation of preoperative cerebral hemodynamic impairment and an objective assessment of postoperative improvement in children with Moyamoya disease.
- Disorders of Microtubule Function in Neurons: Imaging Correlates
MRIs from 18 patients with confirmed tubulin mutations and 15 patients with mutations of the genes encoding microtubule-associated proteins were evaluated. The patients with tubulin gene mutations were found to have cortical and subcortical abnormalities such as microcephaly, ventriculomegaly, abnormal gyral and sulcal patterns, small or absent corpus callosum, and a small pons. Fewer subcortical abnormalities were seen in the microtubule-associated protein mutations group.
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