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This study prospectively compared the image quality and diagnostic performance of conventional MRI and accelerated cervical MRI with DL-based reconstruction in evaluating cervical degenerative spine diseases and myelopathy. The DL-reconstructed protocol demonstrated reduction in scan time, higher or comparable SNR and CNR with higher or similar overall image quality, and higher sensitivity for detecting neural foraminal stenosis and comparable diagnostic performance for other degenerative cervical spinal diseases and myelopathy.