- Validity of the Bern Score as a Surrogate Marker of Clinical Severity in Patients with Spontaneous Intracranial Hypotension
The Bern score quantitatively characterizes brain MR imaging changes in spontaneous intracranial hypotension. This imaging biomarker was shown to have a low correlation with clinical headache severity and, therefore, imaging findings in isolation may have limited utility as primary outcome measures when assessing treatment response.