- Perfusion-Weighted Imaging–Derived Collateral Flow Index is a Predictor of MCA M1 Recanalization after IV Thrombolysis
This article addresses the importance of collateral circulation in preserving the tissues contained within the ischemic penumbra in patients with acute stroke treated with IV thrombolysis. The authors evaluated not only the presence of collaterals but also their quality. They quantified a normalized collateral circulation deficit and correlated it with parameters thought to affect its quality, such as baseline NIHSS score, volume of DWI abnormalities, and modified Rankin scale at 3 months. The normalized collateral circulation deficit correlated with NIHSS, lesion volume as seen on DWI, and recanalization at 24 hours. Full recanalization as well as the probability of full recanalization also correlated with the normalized collateral circulation deficit. Thus, this index is a good predictor of recanalization and outcome in patients with acute stroke treated with IV thrombolysis.
- Robust Perfusion Deficits in Cognitively Impaired Patients with Secondary-Progressive Multiple Sclerosis
These authors investigated the effect of perfusion deficits on patients with MS with cognitive impairment. In 45 patients with secondary-progressive MS, cognition was assessed using standardized clinical tests and CBF and CBV perfusion maps were obtained, analyzed, and correlated with gray and white matter and lesion volumes. Perfusion in the deep gray matter nuclei and frontal cortex was significantly reduced in cognitively impaired patients with MS despite no significant differences regarding gray matter, white matter, and lesion volumes. Of the cognitive parameters investigated, information processing speed was most affected.
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