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These investigators studied the impact of clot location in patients with acute stroke receiving IV thrombolysis. Four locations (ICA, proximal M1, distal M1, and M2 segment and more distal) of clots were correlated with CT perfusion maps, mismatches, salvaged brain volumes, and outcomes in 105 patients. Clots that were more proximal in location produced larger perfusion defects and lesion volumes. The amount of tissue salvaged was greater in patients with more distally located clots. In conclusion, admission CBV defects were larger in proximal vessel occlusions. More of the penumbra was salvaged if the occlusion was located more distally. This effect reached a plateau in the distal M1 segment of the MCA.

These seasoned investigators sought to evaluate the efficacy and safety of flow-diverting devices for the treatment of complex paraclinoid aneurysms in 21 patients and compared their results with historical matched controls treated at their institution. Aneurysm size, location, risk factors, and comorbidities were equal for both groups. In the hands of these authors, flow diverters achieved a higher rate of aneurysm obliteration when compared with other treatments and did not show an increased rate of complications.