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Five patients with brain arteriovenous malformations were studied with flat panel detector CT, DSC-MR imaging, and vessel-encoded pseudocontinuous arterial spin-labeling. Flat panel detector CT, which was originally thought to measure blood volume, correlated more closely with ASL-CBF and DSC-CBF than with DSC-CBV. Flat panel detector CT perfusion depends on the time point chosen for data collection, which is triggered early in patients with AVMs. This finding, in combination with high data variability, makes flat panel detector CT inappropriate for perfusion assessment in brain AVMs.