- Monoclonal Antibodies: What the Diagnostic Neuroradiologist Needs to Know
The therapeutic use of monoclonal antibodies is rapidly expanding for a variety of diseases. This review article describes commonly used monoclonal antibody-targeted therapeutic agents, their mechanism of action, clinical applications, and major adverse events with a focus on neurologic and neuroimaging manifestations. For example, immunostimulating anticancer mAbs can lead to proinflammatory conditions, while immunosuppressive medications can lead to activation of underlying opportunistic infections. Amyloid-segregating mAbs can lead to amyloid-related imaging abnormalities, and TNF-inhibiting mAbs have a higher incidence of demyelinating abnormalities.
- Factors Predictive of Treatment Success in CT-Guided Fibrin Occlusion of CSF-Venous Fistulas: A Multicenter Retrospective Cross-Sectional Study
Multi-institutional retrospective evaluation of patients with CSF-to-venous fistulas treated with CT-guided fibrin glue treatment showed that treatment success may be in part driven by whether the spread of fibrin injectate matches the target drainage pathway of the CVF.
- MR Imaging Appearance of Ruptured Rathke Cleft Cyst and Associated Bone Marrow Enhancement
This clinical case series of 7 patients illustrates the imaging finding of enhancing basisphenoid bone marrow below the sella in cases of ruptured RCC. The mucin leaking out of the ruptured RCC can trigger a cascade of surrounding inflammation, which manifests as abnormal bone marrow enhancement.
AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates