Immunotherapy

Self-assembly nanovaccine containing TLR7/8 agonist and STAT3 inhibitor enhances tumor immunotherapy by augmenting tumor-specific immune response
Lele Zhang, Jiacheng Huang, Xiaona Chen, Caixu Pan, Yong He, Rong Su, Danjing Guo, Shengyong Yin, Shuai Wang, Lin Zhou, Jianxiang Chen, Shusen Zheng, Yiting Qiao

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003132; DOI: 10.1136/jitc-2021-003132
STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation
Takashi Nakamura, Takanori Sato, Rikito Endo, Shun Sasaki, Naomichi Takahashi, Yusuke Sato, Mamoru Hyodo, Yoshihiro Hayakawa, Hideyoshi Harashima

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002852; DOI: 10.1136/jitc-2021-002852
Influence of DM-sensitivity on immunogenicity of MHC class II restricted antigens
Anna Luise Bernhardt, Julia Zeun, Miriam Marecek, Hannah Reimann, Sascha Kretschmann, Judith Bausenwein, Edith D van der Meijden, Margarete M Karg, Tabea Haug, Lisa Meintker, Gloria Lutzny-Geier, Andreas Mackensen, Anita N Kremer

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002401; DOI: 10.1136/jitc-2021-002401
CX-072 (pacmilimab), a Probody PD-L1 inhibitor, in combination with ipilimumab in patients with advanced solid tumors (PROCLAIM-CX-072): a first-in-human, dose-finding study
Rachel E Sanborn, Omid Hamid, Elisabeth GE de Vries, Patrick A Ott, Javier Garcia-Corbacho, Valentina Boni, Johanna Bendell, Karen A Autio, Daniel C Cho, Ruth Plummer, Mark Stroh, Lawrence Lu, Fiona Thistlethwaite

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002446; DOI: 10.1136/jitc-2021-002446
Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies
Gabrielle Leclercq, Hélène Haegel, Anneliese Schneider, Anna Maria Giusti, Estelle Marrer-Berger, Christophe Boetsch, Antje-Christine Walz, Vesna Pulko, Johannes Sam, John Challier, Cristiano Ferlini, Alex Odermatt, Pablo Umaña, Marina Bacac, Christian Klein

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002582; DOI: 10.1136/jitc-2021-002582
Multicenter phase II trial (SWOG S1609, cohort 51) of ipilimumab and nivolumab in metastatic or unresectable angiosarcoma: a substudy of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART)
Michael J Wagner, Megan Othus, Sandip P Patel, Chris Ryan, Ashish Sangal, Benjamin Powers, G Thomas Budd, Adrienne I Victor, Chung-Tsen Hsueh, Rashmi Chugh, Suresh Nair, Kirsten M Leu, Mark Agulnik, Elad Sharon, Edward Mayerson, Melissa Plets, Charles Blanke, Howard Streicher, Young Kwang Chae, Razelle Kurzrock

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002990; DOI: 10.1136/jitc-2021-002990
IL-7 expands lymphocyte populations and enhances immune responses to sipuleucel-T in patients with metastatic castration-resistant prostate cancer (mCRPC)
Russell K Pachynski, Chihiro Morishima, Russell Szmulewitz, Lauren Harshman, Leonard Appleman, Paul Monk, Rhonda L Bitting, Omer Kucuk, Frederick Millard, John D Seigne, Steven P Fling, Holden T Maecker, Caroline Duault, Nirasha Ramchurren, Bruce Hess, Leonard D’Amico, Andreanne Lacroix, Judith C Kaiser, Michel Morre, Anne Grégoire, Martin Cheever, Evan Y Yu, Lawrence Fong

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e002903; DOI: 10.1136/jitc-2021-002903
Timing of steroid initiation and response rates to immune checkpoint inhibitors in metastatic cancer
Diana V Maslov, Karine Tawagi, Madhav KC, Victoria Simenson, Helen Yuan, Cameron Parent, Adi Bamnolker, Richa Goel, Zoe Blake, Marc R Matrana, Daniel H Johnson

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002261; DOI: 10.1136/jitc-2020-002261
Identification of neoantigen-reactive T lymphocytes in the peripheral blood of a patient with glioblastoma
Vid Leko, Gal Cafri, Rami Yossef, Biman Paria, Victoria Hill, Devikala Gurusamy, Zhili Zheng, Jared J Gartner, Todd D Prickett, Stephanie L Goff, Paul Robbins, Yong-Chen Lu, Steven A Rosenberg

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002882; DOI: 10.1136/jitc-2021-002882
Dual PD-L1 and TGF-b blockade in patients with recurrent respiratory papillomatosis
Yvette Robbins, Jay Friedman, Paul E Clavijo, Cem Sievers, Ke Bai, Renee N Donahue, Jeffrey Schlom, Andrew Sinkoe, Houssein Abdul Sater, James L Gulley, Scott Norberg, Christian S Hinrichs, Clint Allen

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003113; DOI: 10.1136/jitc-2021-003113

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