Immunotherapy

Thrombopoietin receptor agonists for acquired thrombocytopenia following anti-CD19 CAR-T-cell therapy: a case report
Rebecca Baur, Regina Jitschin, Soraya Kharboutli, Andrej Stoll, Simon Völkl, Maike Büttner-Herold, Daniela Schmidt, Wolf Rösler, Andreas Mackensen, Dimitrios Mougiakakos

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002721; DOI: 10.1136/jitc-2021-002721
Direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing
Yong-Chen Lu, Zhili Zheng, Frank J Lowery, Jared J Gartner, Todd D Prickett, Paul F Robbins, Steven A Rosenberg

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002595; DOI: 10.1136/jitc-2021-002595
Clinical efficacy of T-cell therapy after short-term BRAF-inhibitor priming in patients with checkpoint inhibitor-resistant metastatic melanoma
Troels Holz Borch, Katja Harbst, Aynal Haque Rana, Rikke Andersen, Evelina Martinenaite, Per Kongsted, Magnus Pedersen, Morten Nielsen, Julie Westerlin Kjeldsen, Anders Handrup Kverneland, Martin Lauss, Lisbet Rosenkrantz Hölmich, Helle Hendel, Özcan Met, Göran Jönsson, Marco Donia, Inge Marie Svane

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002703; DOI: 10.1136/jitc-2021-002703
Exploiting off-target effects of estrogen deprivation to sensitize estrogen receptor negative breast cancer to immune killing
Benjamin Wolfson, Michelle R Padget, Jeffrey Schlom, James W Hodge

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002258; DOI: 10.1136/jitc-2020-002258
GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer
Jin-Li Wei, Si-Yu Wu, Yun-Song Yang, Yi Xiao, Xi Jin, Xiao-En Xu, Xin Hu, Da-Qiang Li, Yi-Zhou Jiang, Zhi-Ming Shao

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002383; DOI: 10.1136/jitc-2021-002383
It’s not ‘just a tube of blood’: principles of protocol development, sample collection, staffing and budget considerations for blood-based biomarkers in immunotherapy studies
Cindy Y Jiang, Zeqi Niu, Michael D Green, Lili Zhao, Shelby Raupp, Brittany Pannecouk, Dean E Brenner, Sunitha Nagrath, Nithya Ramnath

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e003212; DOI: 10.1136/jitc-2021-003212
Immune-related adverse events associated with immune checkpoint inhibitors: a call to action for collecting and sharing clinical trial and real-world data
Kerry L Reynolds, Shaily Arora, Ravikumar Komandur Elayavilli, William C Louv, Teilo H Schaller, Aakanksha Khandelwal, Mace Rothenberg, Sean Khozin, Amanda C Guidon, Michael Dougan, Leyre Zubiri, Laura Petrillo, Meghan E Sise, Alexandra-Chloe Villani, Douglas B Johnson, Osama Rahma, Elad Sharon

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002896; DOI: 10.1136/jitc-2021-002896
Combinatorial immunotherapy of N-803 (IL-15 superagonist) and dinutuximab with ex vivo expanded natural killer cells significantly enhances in vitro cytotoxicity against GD2⁺ pediatric solid tumors and in vivo survival of xenografted immunodeficient NSG mice
Yaya Chu, Gaurav Nayyar, Susiyan Jiang, Jeremy M. Rosenblum, Patrick Soon-Shiong, Jeffrey T Safrit, Dean A. Lee, Mitchell S. Cairo

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002267; DOI: 10.1136/jitc-2020-002267
DNA methylation-based prediction of response to immune checkpoint inhibition in metastatic melanoma
Katharina Filipski, Michael Scherer, Kim N. Zeiner, Andreas Bucher, Johannes Kleemann, Philipp Jurmeister, Tabea I. Hartung, Markus Meissner, Karl H. Plate, Tim R. Fenton, Jörn Walter, Sascha Tierling, Bastian Schilling, Pia S. Zeiner, Patrick N. Harter

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002226; DOI: 10.1136/jitc-2020-002226
Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in the tumor environment is a target for cancer immunotherapy
Katherine W Cook, Wei Xue, Peter Symonds, Ian Daniels, Mohamed Gijon, David Boocock, Clare Coveney, Amanda K Miles, Sabaria Shah, Suha Atabani, Ruhul H Choudhury, Poonam Vaghela, Daisy Weston, Rachael L Metheringham, Victoria A Brentville, Lindy G Durrant

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e001910; DOI: 10.1136/jitc-2020-001910

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