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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Review ArticleNEUROVASCULAR/STROKE IMAGING

Role of Hypoperfusion Intensity Ratio in Vessel Occlusions: A Review on Safety and Clinical Outcomes

Sana Rehman, Arsalan Nadeem, Arbab Burhan Uddin Kasi, Ali Husnain, Summaiyya Waseem, Sohail Kumar, Syed Muhammad Owais, Nasreen Banu, Dhairya A. Lakhani, Hamza A. Salim, Risheng Xu, Vaibhav S. Vagal, Yasmin N. Aziz, Argye E. Hillis, Victor C. Urrutia, Rafael H. Llinas, Elisabeth B. Marsh, Richard Leigh, Hanzhang Lu, Adam A. Dmytriw, Adrien Guenego, Gregory W. Albers, Jeremy J. Heit, Tobias D. Faizy and Vivek S. Yedavalli
American Journal of Neuroradiology May 2025, DOI: https://doi.org/10.3174/ajnr.A8557
Sana Rehman
aFrom the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., G.W.A., V.S.Y.), Johns Hopkins University, Baltimore, Maryland
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Arsalan Nadeem
bDepartment of Medicine (A.N.), Allama Iqbal Medical College, Lahore, Pakistan
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  • ORCID record for Arsalan Nadeem
Arbab Burhan Uddin Kasi
cMass General Brigham (A.B.U.K.), Boston, Massachusetts
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Ali Husnain
dDivision of Interventional Radiology, Department of Radiology, Section of Interventional Radiology (A.H.), Northwestern Memorial Hospital, Chicago, Illinois
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Summaiyya Waseem
eDow University of Health Sciences (S.W.), Karachi, Pakistan
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Sohail Kumar
fHMH JFK University Medical Center (S.K.), Edison, New Jersey
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Syed Muhammad Owais
gUniversity of Toledo (S.M.O.), Toledo, Ohio
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Nasreen Banu
hShadan Institute of Medical Sciences (N.B.), Hyderabad, Telangana, India
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Dhairya A. Lakhani
aFrom the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., G.W.A., V.S.Y.), Johns Hopkins University, Baltimore, Maryland
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Hamza A. Salim
aFrom the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., G.W.A., V.S.Y.), Johns Hopkins University, Baltimore, Maryland
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Risheng Xu
aFrom the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., G.W.A., V.S.Y.), Johns Hopkins University, Baltimore, Maryland
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Vaibhav S. Vagal
iStony Brook University Renaissance School of Medicine (V.S.V.), New York, New York
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Yasmin N. Aziz
jUniversity of Cincinnati College of Medicine (Y.N.A.), Cincinnati, Ohio
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Argye E. Hillis
aFrom the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., G.W.A., V.S.Y.), Johns Hopkins University, Baltimore, Maryland
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Victor C. Urrutia
aFrom the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., G.W.A., V.S.Y.), Johns Hopkins University, Baltimore, Maryland
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Rafael H. Llinas
aFrom the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., G.W.A., V.S.Y.), Johns Hopkins University, Baltimore, Maryland
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Elisabeth B. Marsh
aFrom the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., G.W.A., V.S.Y.), Johns Hopkins University, Baltimore, Maryland
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Richard Leigh
kDepartment of Neurology (R.L.), Johns Hopkins Medicine, Baltimore, Maryland
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Hanzhang Lu
aFrom the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., G.W.A., V.S.Y.), Johns Hopkins University, Baltimore, Maryland
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Adam A. Dmytriw
lNeuroendovascular Program (A.A.D.), Massachusetts General Hospital, Boston, Massachusetts
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Adrien Guenego
mDepartment of Diagnostic and Interventional Neuroradiology (A.G.), Erasme University Hospital, Brussels, Belgium
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Gregory W. Albers
aFrom the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., G.W.A., V.S.Y.), Johns Hopkins University, Baltimore, Maryland
nDepartment of Neurology (G.W.A., J.J.H.), Stanford University, Stanford, California.
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Jeremy J. Heit
nDepartment of Neurology (G.W.A., J.J.H.), Stanford University, Stanford, California.
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Tobias D. Faizy
oDepartment of Radiology, Neuroendovascular Program (T.D.F.), University Medical Center Münster, Munster, Germany
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Vivek S. Yedavalli
aFrom the Department of Radiology and Radiological Sciences (S.R., D.A.L., H.A.S., R.X., A.E.H., V.C.U., R.H.L., E.B.M., H.L., G.W.A., V.S.Y.), Johns Hopkins University, Baltimore, Maryland
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Sana Rehman, Arsalan Nadeem, Arbab Burhan Uddin Kasi, Ali Husnain, Summaiyya Waseem, Sohail Kumar, Syed Muhammad Owais, Nasreen Banu, Dhairya A. Lakhani, Hamza A. Salim, Risheng Xu, Vaibhav S. Vagal, Yasmin N. Aziz, Argye E. Hillis, Victor C. Urrutia, Rafael H. Llinas, Elisabeth B. Marsh, Richard Leigh, Hanzhang Lu, Adam A. Dmytriw, Adrien Guenego, Gregory W. Albers, Jeremy J. Heit, Tobias D. Faizy, Vivek S. Yedavalli
Role of Hypoperfusion Intensity Ratio in Vessel Occlusions: A Review on Safety and Clinical Outcomes
American Journal of Neuroradiology May 2025, DOI: 10.3174/ajnr.A8557

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Role of Hypoperfusion Intensity Ratio in Vessel Occlusions: A Review on Safety and Clinical Outcomes
Sana Rehman, Arsalan Nadeem, Arbab Burhan Uddin Kasi, Ali Husnain, Summaiyya Waseem, Sohail Kumar, Syed Muhammad Owais, Nasreen Banu, Dhairya A. Lakhani, Hamza A. Salim, Risheng Xu, Vaibhav S. Vagal, Yasmin N. Aziz, Argye E. Hillis, Victor C. Urrutia, Rafael H. Llinas, Elisabeth B. Marsh, Richard Leigh, Hanzhang Lu, Adam A. Dmytriw, Adrien Guenego, Gregory W. Albers, Jeremy J. Heit, Tobias D. Faizy, Vivek S. Yedavalli
American Journal of Neuroradiology May 2025, DOI: 10.3174/ajnr.A8557
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  • Article
    • SUMMARY:
    • ABBREVIATIONS:
    • PATHOPHYSIOLOGY OF VESSEL OCCLUSIONS
    • HIR
    • LVO
    • DISTAL MEDIUM-VESSEL OCCLUSION
    • HIR IN COMPARISON WITH OTHER MODALITIES
    • HYPOPERFUSION INDICES MEASUREMENT TECHNIQUES
    • LIMITATIONS, FUTURE DIRECTIONS, AND IMPLICATIONS
    • CONCLUSIONS
    • Footnotes
    • References
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