Research ArticleORIGINAL RESEARCH
The effect of diagnostic hypercapnic cerebrovascular reactivity imaging on vital signs and acute and follow-up ischemic adverse events in patients with flow-limiting intracranial arterial stenosis
Melanie Leguizamon, Caleb Han, Maria Garza, Mackenzie Horne, Wesley T. Richerson, L. Taylor Davis, Dann Martin, Matthew Fusco, Rohan Chitale, Lori C. Jordan and Manus J. Donahue
American Journal of Neuroradiology February 2025, ajnr.A8714; DOI: https://doi.org/10.3174/ajnr.A8714
Melanie Leguizamon
From the Department of Neurology (M.L., C.H., M.H., W.T.R., L.T.D., L.C.J., M.J.D.), Department of Radiology and Radiological Sciences (L.T.D., M.F., R.C., L.C.J.), Department of Neurosurgery (M.F., R.C.), Department of Pediatrics (L.C.J.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Caleb Han
From the Department of Neurology (M.L., C.H., M.H., W.T.R., L.T.D., L.C.J., M.J.D.), Department of Radiology and Radiological Sciences (L.T.D., M.F., R.C., L.C.J.), Department of Neurosurgery (M.F., R.C.), Department of Pediatrics (L.C.J.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Maria Garza
From the Department of Neurology (M.L., C.H., M.H., W.T.R., L.T.D., L.C.J., M.J.D.), Department of Radiology and Radiological Sciences (L.T.D., M.F., R.C., L.C.J.), Department of Neurosurgery (M.F., R.C.), Department of Pediatrics (L.C.J.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Mackenzie Horne
From the Department of Neurology (M.L., C.H., M.H., W.T.R., L.T.D., L.C.J., M.J.D.), Department of Radiology and Radiological Sciences (L.T.D., M.F., R.C., L.C.J.), Department of Neurosurgery (M.F., R.C.), Department of Pediatrics (L.C.J.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Wesley T. Richerson
From the Department of Neurology (M.L., C.H., M.H., W.T.R., L.T.D., L.C.J., M.J.D.), Department of Radiology and Radiological Sciences (L.T.D., M.F., R.C., L.C.J.), Department of Neurosurgery (M.F., R.C.), Department of Pediatrics (L.C.J.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
L. Taylor Davis
From the Department of Neurology (M.L., C.H., M.H., W.T.R., L.T.D., L.C.J., M.J.D.), Department of Radiology and Radiological Sciences (L.T.D., M.F., R.C., L.C.J.), Department of Neurosurgery (M.F., R.C.), Department of Pediatrics (L.C.J.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Dann Martin
From the Department of Neurology (M.L., C.H., M.H., W.T.R., L.T.D., L.C.J., M.J.D.), Department of Radiology and Radiological Sciences (L.T.D., M.F., R.C., L.C.J.), Department of Neurosurgery (M.F., R.C.), Department of Pediatrics (L.C.J.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Matthew Fusco
From the Department of Neurology (M.L., C.H., M.H., W.T.R., L.T.D., L.C.J., M.J.D.), Department of Radiology and Radiological Sciences (L.T.D., M.F., R.C., L.C.J.), Department of Neurosurgery (M.F., R.C.), Department of Pediatrics (L.C.J.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Rohan Chitale
From the Department of Neurology (M.L., C.H., M.H., W.T.R., L.T.D., L.C.J., M.J.D.), Department of Radiology and Radiological Sciences (L.T.D., M.F., R.C., L.C.J.), Department of Neurosurgery (M.F., R.C.), Department of Pediatrics (L.C.J.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Lori C. Jordan
From the Department of Neurology (M.L., C.H., M.H., W.T.R., L.T.D., L.C.J., M.J.D.), Department of Radiology and Radiological Sciences (L.T.D., M.F., R.C., L.C.J.), Department of Neurosurgery (M.F., R.C.), Department of Pediatrics (L.C.J.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Manus J. Donahue
From the Department of Neurology (M.L., C.H., M.H., W.T.R., L.T.D., L.C.J., M.J.D.), Department of Radiology and Radiological Sciences (L.T.D., M.F., R.C., L.C.J.), Department of Neurosurgery (M.F., R.C.), Department of Pediatrics (L.C.J.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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Accepted Manuscript
Melanie Leguizamon, Caleb Han, Maria Garza, Mackenzie Horne, Wesley T. Richerson, L. Taylor Davis, Dann Martin, Matthew Fusco, Rohan Chitale, Lori C. Jordan, Manus J. Donahue
The effect of diagnostic hypercapnic cerebrovascular reactivity imaging on vital signs and acute and follow-up ischemic adverse events in patients with flow-limiting intracranial arterial stenosis
American Journal of Neuroradiology Feb 2025, ajnr.A8714; DOI: 10.3174/ajnr.A8714
Accepted Manuscript
The effect of diagnostic hypercapnic cerebrovascular reactivity imaging on vital signs and acute and follow-up ischemic adverse events in patients with flow-limiting intracranial arterial stenosis
Melanie Leguizamon, Caleb Han, Maria Garza, Mackenzie Horne, Wesley T. Richerson, L. Taylor Davis, Dann Martin, Matthew Fusco, Rohan Chitale, Lori C. Jordan, Manus J. Donahue
American Journal of Neuroradiology Feb 2025, ajnr.A8714; DOI: 10.3174/ajnr.A8714
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