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Research ArticleULTRA-HIGH-FIELD MRI/IMAGING OF EPILEPSY/DEMYELINATING DISEASES/INFLAMMATION/INFECTION

DSC MR Perfusion at 7T MRI: An Initial Single-Center Study for Validity and Practicability

Clare E. Buntrock, Ceren Dinçer, Onur Tuncer, Matthew White, Alexis Swensen, Mark Folkertsma and Can Özütemiz
American Journal of Neuroradiology February 2025, DOI: https://doi.org/10.3174/ajnr.A8513
Clare E. Buntrock
aFrom the University of Minnesota Medical School (C.E.B.), Minneapolis, Minnesota
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Ceren Dinçer
bDepartment of Radiology (C.D.), Hacettepe University, Faculty of Medicine, Ankara, Turkiye
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Onur Tuncer
cDepartment of Radiology (O.T.), Yeditepe University, Faculty of Medicine, Istanbul, Turkiye
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Matthew White
dCenter for Clinical Imaging Research (M.W.), University of Minnesota, Minneapolis, Minnesota
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Alexis Swensen
eDepartment of Radiology (A.S., M.F., C.Ö.), University of Minnesota Medical School, Minneapolis, Minnesota
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Mark Folkertsma
eDepartment of Radiology (A.S., M.F., C.Ö.), University of Minnesota Medical School, Minneapolis, Minnesota
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Can Özütemiz
eDepartment of Radiology (A.S., M.F., C.Ö.), University of Minnesota Medical School, Minneapolis, Minnesota
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Abstract

BACKGROUND AND PURPOSE: DSC perfusion is an advanced imaging technique routinely used at 1.5T and 3T MRI. However, its utility is not well known in 7T MRI systems. We aim to evaluate if DSC perfusion is a valid and practicable tool at 7T MRI.

MATERIALS AND METHODS: A successful DSC perfusion was performed in 9 patients with an FDA-approved 7T MRI system (Siemens Terra with 1tx/32rx Nova head coil) in 2023. Half-dose contrast was administered by hand, followed by saline flush. Acquisition was initiated 45 seconds before contrast injection. Voxel size was 1.5 × 1.5 × 1.6 mm3. Perfusion maps were generated by using either SyngoVia or DynaSuite software. Parameters including relative CBV (rCBV), relative CBF (rCBF), relative MTT (rMTT), and relative TTP (rTTP) were measured in 5 anatomic locations bilaterally (precentral gyrus, middle frontal gyrus, corona radiata, thalamus, occipital cortex) and enhancing lesions if present. Normalized ratios of rCBV (nrCBV), rCBF (nrCBF), rMTT (nrMTT), and rTTP (nrTTP) were calculated and compared on boxplots. Two neuroradiologists reviewed each scan visually by using a 5-point Likert scale regarding imaging quality and artifacts. Qualitative and quantitative assessments were made on DSC perfusion in cases with enhanced target lesions.

RESULTS: Uploading the source images to imaging software took approximately 30 minutes to a few hours. In a few circumstances, large data caused software crashes. Map generation took approximately 10–15 minutes. Susceptibility artifacts varied from mild to moderate in cerebellum, temporal lobes, brainstem, and basal ganglia and none to minimal in the frontal, occipital, and parietal gyri. Map quality was excellent to reasonably good for all cases. The nrCBV, nrCBF, nrMTT, and nrTTP resulted in similar measurements for each anatomic area. Six target lesions were assessed in 2 different patients with well to excellent visualization on fused maps. Three lesions were characterized as tumor progression (1 biopsy-confirmed, 2 unconfirmed), 1 lesion as indeterminant (regressed in follow-up), and 2 lesions as radiation necrosis (1 stable, 1 regressed on follow-up).

CONCLUSIONS: Despite limitations with postprocessing issues, it is possible to reliably measure nrCBV, nrCBF, nrMTT, and nrTTP values with DSC perfusion by using a clinical 7T MRI system, and qualitatively, excellent or reasonably good fusion maps can be generated with high resolution.

ABBREVIATIONS:

ASFNR
American Society of Functional Neuroradiology
GBCA
gadolinium-based contrast agent
GRE
gradient echo
NAWM
normal-appearing white matter
nrCBF
normalized ratio of relative CBF
nrCBV
normalized ratio of relative CBV
nrMTT
normalized ratio of relative MTT
nrTTP
normalized ratio of relative TTP
rCBF
relative CBF
rCBV
relative CBV
rMTT
relative MTT
rTTP
relative TTP

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  • © 2025 by American Journal of Neuroradiology
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Cite this article
Clare E. Buntrock, Ceren Dinçer, Onur Tuncer, Matthew White, Alexis Swensen, Mark Folkertsma, Can Özütemiz
DSC MR Perfusion at 7T MRI: An Initial Single-Center Study for Validity and Practicability
American Journal of Neuroradiology Feb 2025, DOI: 10.3174/ajnr.A8513

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Dynamic MR Perfusion at 7T: Initial Study Insights
Clare E. Buntrock, Ceren Dinçer, Onur Tuncer, Matthew White, Alexis Swensen, Mark Folkertsma, Can Özütemiz
American Journal of Neuroradiology Feb 2025, DOI: 10.3174/ajnr.A8513
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