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Research ArticlePEDIATRIC NEUROIMAGING

CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis

A. Tietze, B. Bison, J. Engelhardt, T. Fenouil, D. Figarella-Branger, E. Goebell, J. Hakumäki, E. Koscielniak, L.E. Ludlow, D. Meyronet, P. Nyman, I. Øra, J. Pesola, T. Rauramaa, R.E. Reddingius, D. Samuel, A. Sexton-Oates, A. Vasiljevic, A.K. Wefers, J. Zamecnik, D.T.W. Jones, M.K. Keck, K. von Hoff and European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group
American Journal of Neuroradiology February 2025, DOI: https://doi.org/10.3174/ajnr.A8496
A. Tietze
aFrom the Institute of Neuroradiology (A.T.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
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B. Bison
bDepartment of Neuroradiology (B.B.), University Hospital Augsburg, Augsburg, Germany
cFaculty of Medicine (B.B.), Neuroradiological Reference Center for the pediatric brain tumor studies of the German Society of Pediatric Oncology and Hematology, University Augsburg, Augsburg, Germany
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J. Engelhardt
dService de Neurochirurgie B (J.E.), Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
eUniversity Bordeaux (J.E.), Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France
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T. Fenouil
fInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France
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D. Figarella-Branger
gInstitute Neurophysiopathol (D.F.-B.), Aix-Marseille University, APHM, CNRS, INP, centre hospitalier universitaire Timone, Service d’Anatomie Pathologique et de Neuropathologie, Marseille, France
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E. Goebell
hDepartment of Diagnostic and Interventional Neuroradiology (E.G.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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J. Hakumäki
iDepartment of Clinical Radiology (J.H.), Kuopio University Hospital, Kuopio, Finland
jInstitute of Clinical Medicine (J.H.), University of Eastern Finland, Kuopio, Finland
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E. Koscielniak
kDepartment of Pediatric Oncology/Hematology/Immunology (E.K.), Olgahospital, Klinikum Stuttgart, Stuttgart, Germany
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L.E. Ludlow
lMurdoch Children’s Research Institute (L.E.L.), and Children’s Cancer Centre (L.E.L.), The Royal Children’s Hospital, Parkville, Victoria, Australia
mDepartment of Paediatrics (L.E.L.), The University of Melbourne, Parkville, Victoria, Australia
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D. Meyronet
fInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France
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P. Nyman
nCrown Princess Victoria Children’s Hospital (P.N.), Linköping University Hospital, Linköping, Sweden
oDepartment of Biomedical and Clinical Sciences (P.N.), Linköping University, Linköping, Sweden
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I. Øra
pClinical Sciences, Pediatric Oncology and Hematology (I.O.), Lund University, Lund, Sweden
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J. Pesola
qDepartment of Pediatrics (J.P.), Pediatric Hematology and Oncology Ward, Kuopio University Hospital, Kuopio, Finland
rInstitute of Clinical Medicine (J.P., T.R.) University of Eastern Finland, Kuopio, Finland
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T. Rauramaa
rInstitute of Clinical Medicine (J.P., T.R.) University of Eastern Finland, Kuopio, Finland
sDepartment of Clinical Pathology (T.R.), Kuopio University Hospital, Kuopio, Finland
tDepartment of Clinical Pathology (T.R.), Kuopio University Hospital and Unit of Pathology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
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R.E. Reddingius
uDepartment of Neuro-Oncology (R.E.R.), Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
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D. Samuel
vDepartment of Pediatric Hematology-Oncology (D.S.), Valley Children’s Hospital, Madera, California
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A. Sexton-Oates
wRare Cancers Genomics Team (A.S.-O.), Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France
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A. Vasiljevic
fInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France
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A.K. Wefers
xInstitute of Neuropathology (A.K.W.), and Mildred Scheel Cancer Career Center HaTriCS4 (A.K.W.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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J. Zamecnik
yDepartment of Pathology and Molecular Medicine (J.Z.), Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
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D.T.W. Jones
zDivision of Pediatric Glioma Research (D.T.W.J., M.K.K.), Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
aaNational Center for Tumor Diseases (NCT) (D.T.W.J., M.K.K.), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
bbGerman Cancer Research Center (DKFZ) (D.T.W.J., M.K.K.), Heidelberg, Germany
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M.K. Keck
zDivision of Pediatric Glioma Research (D.T.W.J., M.K.K.), Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
aaNational Center for Tumor Diseases (NCT) (D.T.W.J., M.K.K.), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
bbGerman Cancer Research Center (DKFZ) (D.T.W.J., M.K.K.), Heidelberg, Germany
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K. von Hoff
ccDepartment of Pediatric Oncology and Hematology (K.v.H.), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany
ddDepartment of Paediatric and Adolescent Medicine (K.v.H.), Aarhus University Hospital, Aarhus, Denmark
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A8496
PubMed 
39271290

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received June 23, 2024
  • Accepted after revision September 10, 2024
  • Published online February 20, 2025.

Article Versions

  • Latest version (September 13, 2024 - 10:25).
  • You are currently viewing a Latest version of this article (February 20, 2025 - 09:30).
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Copyright & Usage 
© 2025 by American Journal of Neuroradiology

Author Information

  1. A. Tietzea,
  2. B. Bisonb,c,
  3. J. Engelhardtd,e,
  4. T. Fenouilf,
  5. D. Figarella-Brangerg,
  6. E. Goebellh,
  7. J. Hakumäkii,j,
  8. E. Koscielniakk,
  9. L.E. Ludlowl,m,
  10. D. Meyronetf,
  11. P. Nymann,o,
  12. I. Ørap,
  13. J. Pesolaq,r,
  14. T. Rauramaar,s,t,
  15. R.E. Reddingiusu,
  16. D. Samuelv,
  17. A. Sexton-Oatesw,
  18. A. Vasiljevicf,
  19. A.K. Wefersx,
  20. J. Zamecniky,
  21. D.T.W. Jonesz,aa,bb,
  22. M.K. Keckz,aa,bb,
  23. K. von Hoffcc,dd,
  24. European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group
  1. aFrom the Institute of Neuroradiology (A.T.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
  2. bDepartment of Neuroradiology (B.B.), University Hospital Augsburg, Augsburg, Germany
  3. cFaculty of Medicine (B.B.), Neuroradiological Reference Center for the pediatric brain tumor studies of the German Society of Pediatric Oncology and Hematology, University Augsburg, Augsburg, Germany
  4. dService de Neurochirurgie B (J.E.), Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
  5. eUniversity Bordeaux (J.E.), Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France
  6. fInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France
  7. gInstitute Neurophysiopathol (D.F.-B.), Aix-Marseille University, APHM, CNRS, INP, centre hospitalier universitaire Timone, Service d’Anatomie Pathologique et de Neuropathologie, Marseille, France
  8. hDepartment of Diagnostic and Interventional Neuroradiology (E.G.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  9. iDepartment of Clinical Radiology (J.H.), Kuopio University Hospital, Kuopio, Finland
  10. jInstitute of Clinical Medicine (J.H.), University of Eastern Finland, Kuopio, Finland
  11. kDepartment of Pediatric Oncology/Hematology/Immunology (E.K.), Olgahospital, Klinikum Stuttgart, Stuttgart, Germany
  12. lMurdoch Children’s Research Institute (L.E.L.), and Children’s Cancer Centre (L.E.L.), The Royal Children’s Hospital, Parkville, Victoria, Australia
  13. mDepartment of Paediatrics (L.E.L.), The University of Melbourne, Parkville, Victoria, Australia
  14. nCrown Princess Victoria Children’s Hospital (P.N.), Linköping University Hospital, Linköping, Sweden
  15. oDepartment of Biomedical and Clinical Sciences (P.N.), Linköping University, Linköping, Sweden
  16. pClinical Sciences, Pediatric Oncology and Hematology (I.O.), Lund University, Lund, Sweden
  17. qDepartment of Pediatrics (J.P.), Pediatric Hematology and Oncology Ward, Kuopio University Hospital, Kuopio, Finland
  18. rInstitute of Clinical Medicine (J.P., T.R.) University of Eastern Finland, Kuopio, Finland
  19. sDepartment of Clinical Pathology (T.R.), Kuopio University Hospital, Kuopio, Finland
  20. tDepartment of Clinical Pathology (T.R.), Kuopio University Hospital and Unit of Pathology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
  21. uDepartment of Neuro-Oncology (R.E.R.), Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
  22. vDepartment of Pediatric Hematology-Oncology (D.S.), Valley Children’s Hospital, Madera, California
  23. wRare Cancers Genomics Team (A.S.-O.), Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France
  24. xInstitute of Neuropathology (A.K.W.), and Mildred Scheel Cancer Career Center HaTriCS4 (A.K.W.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  25. yDepartment of Pathology and Molecular Medicine (J.Z.), Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
  26. zDivision of Pediatric Glioma Research (D.T.W.J., M.K.K.), Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
  27. aaNational Center for Tumor Diseases (NCT) (D.T.W.J., M.K.K.), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
  28. bbGerman Cancer Research Center (DKFZ) (D.T.W.J., M.K.K.), Heidelberg, Germany
  29. ccDepartment of Pediatric Oncology and Hematology (K.v.H.), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany
  30. ddDepartment of Paediatric and Adolescent Medicine (K.v.H.), Aarhus University Hospital, Aarhus, Denmark
                                                                                  1. Please address correspondence to Anna Tietze, MD, Institute of Neuroradiology, Charité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Augustenburger Platz 1 D, 13353 Berlin, Germany; e-mail: anna.tietze{at}charite.de
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                                                                                  Funding

                                                                                  • Deutsche Forschungsgemeinschaft

                                                                                    DFG, SFB295RETUNE
                                                                                  • Styrian Children's Cancer Aid

                                                                                  • Deutsche Kinderkrebsstiftung

                                                                                    DKS 2023.10
                                                                                  • Ministerstvo Zdravotnictví Ceské Republiky

                                                                                    NU23-08-00460

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                                                                                  This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

                                                                                  • Comparative Clinical and Imaging‐Based Evaluation of Therapeutic Modalities in CNS Embryonal Tumours With PLAGL Amplification
                                                                                    Michaela‐Kristina Keck, Anna Tietze, Brigitte Bison, Shivaram Avula, Julien Engelhardt, Cécile Faure‐Conter, Tanguy Fenouil, Dominique Figarella‐Branger, Einar Goebell, Johannes Gojo, Christine Haberler, Juhana Hakumäki, James T. Hayden, Laura S. Korhonen, Ewa Koscielniak, Christof M. Kramm, Mariëtte E. G. Kranendonk, Maarten Lequin, Louise E. Ludlow, David Meyronet, Per Nyman, Ingrid Øra, Thomas Perwein, Jouni Pesola, Tuomas Rauramaa, Roel Reddingius, David Samuel, Antoinette Y. N. Schouten‐van Meeteren, Alexandra Sexton‐Oates, Alexandre Vasiljevic, Thekla von Kalle, Annika K. Wefers, Pieter Wesseling, Josef Zamecnik, Michal Zapotocky, Katja von Hoff, David T. W. Jones
                                                                                    Neuropathology and Applied Neurobiology 2025 51 2
                                                                                  • Radiologische Merkmale embryonaler Tumore mit PLAGL-Amplifikation
                                                                                    Neuroradiologie Scan 2025 15 02
                                                                                  • Radiopaedia.org
                                                                                    Frank Gaillard
                                                                                    2025
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                                                                                  Cite this article
                                                                                  A. Tietze, B. Bison, J. Engelhardt, T. Fenouil, D. Figarella-Branger, E. Goebell, J. Hakumäki, E. Koscielniak, L.E. Ludlow, D. Meyronet, P. Nyman, I. Øra, J. Pesola, T. Rauramaa, R.E. Reddingius, D. Samuel, A. Sexton-Oates, A. Vasiljevic, A.K. Wefers, J. Zamecnik, D.T.W. Jones, M.K. Keck, K. von Hoff, European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group
                                                                                  CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis
                                                                                  American Journal of Neuroradiology Feb 2025, DOI: 10.3174/ajnr.A8496

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                                                                                  New CNS Embryonal Tumor Insights via MRI Analysis
                                                                                  A. Tietze, B. Bison, J. Engelhardt, T. Fenouil, D. Figarella-Branger, E. Goebell, J. Hakumäki, E. Koscielniak, L.E. Ludlow, D. Meyronet, P. Nyman, I. Øra, J. Pesola, T. Rauramaa, R.E. Reddingius, D. Samuel, A. Sexton-Oates, A. Vasiljevic, A.K. Wefers, J. Zamecnik, D.T.W. Jones, M.K. Keck, K. von Hoff, European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group
                                                                                  American Journal of Neuroradiology Feb 2025, DOI: 10.3174/ajnr.A8496
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                                                                                  • Crossref (3)
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                                                                                  This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

                                                                                  • Comparative Clinical and Imaging‐Based Evaluation of Therapeutic Modalities in CNS Embryonal Tumours With PLAGL Amplification
                                                                                    Michaela‐Kristina Keck, Anna Tietze, Brigitte Bison, Shivaram Avula, Julien Engelhardt, Cécile Faure‐Conter, Tanguy Fenouil, Dominique Figarella‐Branger, Einar Goebell, Johannes Gojo, Christine Haberler, Juhana Hakumäki, James T. Hayden, Laura S. Korhonen, Ewa Koscielniak, Christof M. Kramm, Mariëtte E. G. Kranendonk, Maarten Lequin, Louise E. Ludlow, David Meyronet, Per Nyman, Ingrid Øra, Thomas Perwein, Jouni Pesola, Tuomas Rauramaa, Roel Reddingius, David Samuel, Antoinette Y. N. Schouten‐van Meeteren, Alexandra Sexton‐Oates, Alexandre Vasiljevic, Thekla von Kalle, Annika K. Wefers, Pieter Wesseling, Josef Zamecnik, Michal Zapotocky, Katja von Hoff, David T. W. Jones
                                                                                    Neuropathology and Applied Neurobiology 2025 51 2
                                                                                  • Radiologische Merkmale embryonaler Tumore mit PLAGL-Amplifikation
                                                                                    Neuroradiologie Scan 2025 15 02
                                                                                  • Radiopaedia.org
                                                                                    Frank Gaillard
                                                                                    2025

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