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Research ArticleORIGINAL RESEARCH

Sex-specific association between anatomical variants of the circle of Willis and intracranial aneurysms in individuals with a familial predisposition

Marloes H.A. Nanninga, Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Iris N. Vos, Phebe J. Groenheide, Ynte M. Ruigrok and Irene C. van der Schaaf
American Journal of Neuroradiology February 2025, ajnr.A8690; DOI: https://doi.org/10.3174/ajnr.A8690
Marloes H.A. Nanninga
From the Department of Neurology and Neurosurgery, UMC Utrecht Brain Center (Marloes H.A. Nanninga, Phebe J. Groenheide, Ynte M. Ruigrok), Department of Radiology (Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Irene C. van der Schaaf), and Image Sciences Institute (Iris N. Vos), University Medical Center Utrecht, Utrecht, the Netherlands.
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Denise A.M. van Strien
From the Department of Neurology and Neurosurgery, UMC Utrecht Brain Center (Marloes H.A. Nanninga, Phebe J. Groenheide, Ynte M. Ruigrok), Department of Radiology (Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Irene C. van der Schaaf), and Image Sciences Institute (Iris N. Vos), University Medical Center Utrecht, Utrecht, the Netherlands.
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Birgitta K. Velthuis
From the Department of Neurology and Neurosurgery, UMC Utrecht Brain Center (Marloes H.A. Nanninga, Phebe J. Groenheide, Ynte M. Ruigrok), Department of Radiology (Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Irene C. van der Schaaf), and Image Sciences Institute (Iris N. Vos), University Medical Center Utrecht, Utrecht, the Netherlands.
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Mireille R.E. Velthuis
From the Department of Neurology and Neurosurgery, UMC Utrecht Brain Center (Marloes H.A. Nanninga, Phebe J. Groenheide, Ynte M. Ruigrok), Department of Radiology (Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Irene C. van der Schaaf), and Image Sciences Institute (Iris N. Vos), University Medical Center Utrecht, Utrecht, the Netherlands.
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Iris N. Vos
From the Department of Neurology and Neurosurgery, UMC Utrecht Brain Center (Marloes H.A. Nanninga, Phebe J. Groenheide, Ynte M. Ruigrok), Department of Radiology (Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Irene C. van der Schaaf), and Image Sciences Institute (Iris N. Vos), University Medical Center Utrecht, Utrecht, the Netherlands.
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Phebe J. Groenheide
From the Department of Neurology and Neurosurgery, UMC Utrecht Brain Center (Marloes H.A. Nanninga, Phebe J. Groenheide, Ynte M. Ruigrok), Department of Radiology (Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Irene C. van der Schaaf), and Image Sciences Institute (Iris N. Vos), University Medical Center Utrecht, Utrecht, the Netherlands.
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Ynte M. Ruigrok
From the Department of Neurology and Neurosurgery, UMC Utrecht Brain Center (Marloes H.A. Nanninga, Phebe J. Groenheide, Ynte M. Ruigrok), Department of Radiology (Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Irene C. van der Schaaf), and Image Sciences Institute (Iris N. Vos), University Medical Center Utrecht, Utrecht, the Netherlands.
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Irene C. van der Schaaf
From the Department of Neurology and Neurosurgery, UMC Utrecht Brain Center (Marloes H.A. Nanninga, Phebe J. Groenheide, Ynte M. Ruigrok), Department of Radiology (Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Irene C. van der Schaaf), and Image Sciences Institute (Iris N. Vos), University Medical Center Utrecht, Utrecht, the Netherlands.
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Article Information

ajnr.A8690
DOI 
https://doi.org/10.3174/ajnr.A8690
PubMed 
39909568

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Published online February 5, 2025.

Copyright & Usage 
© 2025 by American Journal of Neuroradiology

Author Information

  1. Marloes H.A. Nanninga,
  2. Denise A.M. van Strien,
  3. Birgitta K. Velthuis,
  4. Mireille R.E. Velthuis,
  5. Iris N. Vos,
  6. Phebe J. Groenheide,
  7. Ynte M. Ruigrok and
  8. Irene C. van der Schaaf
  1. From the Department of Neurology and Neurosurgery, UMC Utrecht Brain Center (Marloes H.A. Nanninga, Phebe J. Groenheide, Ynte M. Ruigrok), Department of Radiology (Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Irene C. van der Schaaf), and Image Sciences Institute (Iris N. Vos), University Medical Center Utrecht, Utrecht, the Netherlands.
  1. Please address correspondence to Ynte M. Ruigrok, MD PhD, Department of Neurology and Neuroradiology, University Medical Center Utrecht, Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; ij.m.ruigrok{at}umcutrecht.nl.

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Accepted Manuscript
Marloes H.A. Nanninga, Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Iris N. Vos, Phebe J. Groenheide, Ynte M. Ruigrok, Irene C. van der Schaaf
Sex-specific association between anatomical variants of the circle of Willis and intracranial aneurysms in individuals with a familial predisposition
American Journal of Neuroradiology Feb 2025, ajnr.A8690; DOI: 10.3174/ajnr.A8690

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Accepted Manuscript
Sex-specific association between anatomical variants of the circle of Willis and intracranial aneurysms in individuals with a familial predisposition
Marloes H.A. Nanninga, Denise A.M. van Strien, Birgitta K. Velthuis, Mireille R.E. Velthuis, Iris N. Vos, Phebe J. Groenheide, Ynte M. Ruigrok, Irene C. van der Schaaf
American Journal of Neuroradiology Feb 2025, ajnr.A8690; DOI: 10.3174/ajnr.A8690
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