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Research ArticleNEUROVASCULAR/STROKE IMAGING

Quantification of Collateral Supply with Local-AIF Dynamic Susceptibility Contrast MRI Predicts Infarct Growth

Mira M. Liu, Niloufar Saadat, Steven P. Roth, Marek A. Niekrasz, Mihai Giurcanu, Timothy J. Carroll and Gregory A. Christoforidis
American Journal of Neuroradiology January 2025, DOI: https://doi.org/10.3174/ajnr.A8441
Mira M. Liu
aFrom the Department of Radiology Medical Physics (M.M.L., T.J.C.), University of Chicago, Chicago, Illinois
bBiomedical Engineering and Imaging Institute (M.M.L.), Icahn School of Medicine at Mount Sinai, New York, New York
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Niloufar Saadat
cDepartment of Interventional Radiology (N.S., G.A.C.), University of Chicago, Chicago, Illinois
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Steven P. Roth
dDepartment of Anesthesiology (S.P.R.), University of Illinois, Chicago, Illinois
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Marek A. Niekrasz
eDepartment of Surgery and Large Animal Studies (M.A.N.), University of Chicago, Chicago, Illinois
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Mihai Giurcanu
fDepartment of Statistics (M.G.), University of Chicago, Chicago, Illinois
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Timothy J. Carroll
aFrom the Department of Radiology Medical Physics (M.M.L., T.J.C.), University of Chicago, Chicago, Illinois
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Gregory A. Christoforidis
cDepartment of Interventional Radiology (N.S., G.A.C.), University of Chicago, Chicago, Illinois
gMount Carmel Health Systems (G.A.C.), Columbus, Ohio
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References

  1. 1.↵
    1. Liebeskind DS,
    2. Saber H,
    3. Xiang B
    ; DAWN Investigators, et al. Collateral circulation in thrombectomy for stroke after 6 to 24 hours in the DAWN trial. Stroke 2022;53:742–48 doi:10.1161/STROKEAHA.121.034471 pmid:34727737
    CrossRefPubMed
  2. 2.↵
    1. Winship IR
    . Cerebral collaterals and collateral therapeutics for acute ischemic stroke. Microcirculation 2015;22:228–36 doi:10.1111/micc.12177 pmid:25351102
    CrossRefPubMed
  3. 3.↵
    1. Marks MP,
    2. Heit JJ,
    3. Lansberg MG
    ; DEFUSE 3 Investigators, et al. Endovascular treatment in the DEFUSE 3 study. Stroke 2018;49:2000–03 doi:10.1161/STROKEAHA.118.022147 pmid:29986935
    CrossRefPubMed
  4. 4.↵
    1. Shazeeb MS,
    2. King RM,
    3. Anagnostakou V, et al
    . Novel oxygen carrier slows infarct growth in large vessel occlusion dog model based on magnetic resonance imaging analysis. Stroke 2022;53:1363–72 doi:10.1161/STROKEAHA.121.036896 pmid:35306836
    CrossRefPubMed
  5. 5.↵
    1. Christoforidis GA,
    2. Saadat N,
    3. Liu M, et al
    . Effect of early sanguinate (PEGylated carboxyhemoglobin bovine) infusion on cerebral blood flow to the ischemic core in experimental middle cerebral artery occlusion. J Neurointerv Surg 2022;14:1253–57 doi:10.1136/neurintsurg-2021-018239 pmid:34907008
    Abstract/FREE Full Text
  6. 6.↵
    1. Saadat N,
    2. Christoforidis GA,
    3. Jeong YI, et al
    . Influence of simultaneous pressor and vasodilatory agents on the evolution of infarct growth in experimental acute middle cerebral artery occlusion. J Neurointerv Surg 2020;13:741–45 doi:10.1136/neurintsurg-2020-016539 pmid:32900906
    Abstract/FREE Full Text
  7. 7.↵
    1. Liu M,
    2. Saadat N,
    3. Jeong YI, et al
    . Augmentation of perfusion with simultaneous vasodilator and inotropic agents in experimental acute middle cerebral artery occlusion: a pilot study. J Neurointerv Surg 2023;15:e69–75 doi:10.1136/jnis-2022-018990 pmid:35803730
    Abstract/FREE Full Text
  8. 8.↵
    1. Lee MJ,
    2. Son JP,
    3. Kim SJ, et al
    . Predicting collateral status with magnetic resonance perfusion parameters: probabilistic approach with a Tmax-derived prediction model. Stroke 2015;46:2800–07 doi:10.1161/STROKEAHA.115.009828 pmid:26306754
    Abstract/FREE Full Text
  9. 9.↵
    1. Jeong YI,
    2. Christoforidis GA,
    3. Saadat N, et al
    . Absolute quantitative MR perfusion and comparison against stable‐isotope microspheres. Magn Reson Med 2019;81:3567–77
    CrossRefPubMed
  10. 10.↵
    1. Mouannes-Srour JJ,
    2. Shin W,
    3. Ansari SA, et al
    . Correction for arterial-tissue delay and dispersion in absolute quantitative cerebral perfusion DSC MR imaging. Magn Reson Med 2012;68:495–506 doi:10.1002/mrm.23257 pmid:22162092
    CrossRefPubMed
  11. 11.↵
    1. Calamante F,
    2. Willats L,
    3. Gadian DG, et al
    . Bolus delay and dispersion in perfusion MRI: implications for tissue predictor models in stroke. Magn Reson Med 2006;55:1180–85 doi:10.1002/mrm.20873 pmid:16598717
    CrossRefPubMed
  12. 12.↵
    1. Rink C,
    2. Christoforidis G,
    3. Abduljalil A, et al
    . Minimally invasive neuroradiologic model of preclinical transient middle cerebral artery occlusion in canines. Proc Natl Acad Sci U S A 2008;105:14100–05 doi:10.1073/pnas.0806678105 pmid:18779582
    Abstract/FREE Full Text
  13. 13.↵
    1. Christoforidis GA,
    2. Rink C,
    3. Kontzialis MS, et al
    . An endovascular canine middle cerebral artery occlusion model for the study of leptomeningeal collateral recruitment. Invest Radiol 2011;46:34–40 doi:10.1097/RLI.0b013e3181f0cbc7 pmid:20856126
    CrossRefPubMed
  14. 14.↵
    1. Christoforidis GA,
    2. Vakil P,
    3. Ansari SA, et al
    . Impact of pial collaterals on infarct growth rate in experimental acute ischemic stroke. AJNR Am J Neuroradiol 2017;38:270–75 doi:10.3174/ajnr.A5003 pmid:27856435
    Abstract/FREE Full Text
  15. 15.↵
    1. Christoforidis GA,
    2. Mohammad Y,
    3. Kehagias D, et al
    . Angiographic assessment of pial collaterals as a prognostic indicator following intra-arterial thrombolysis for acute ischemic stroke. AJNR Am J Neuroradiol 2005;26:1789–97 pmid:16091531
    PubMedWeb of Science
  16. 16.↵
    1. Carroll TJ,
    2. Rowley HA,
    3. Haughton VM
    . Automatic calculation of the arterial input function for cerebral perfusion imaging with MR imaging. Radiology 2003;227:593–600 doi:10.1148/radiol.2272020092 pmid:12663823
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Carroll TJ,
    2. Horowitz S,
    3. Shin W, et al
    . Quantification of cerebral perfusion using the “bookend technique”: an evaluation in CNS tumors. Magn Reson Imaging 2008;26:1352–59 doi:10.1016/j.MRI.2008.04.010 pmid:18538523
    CrossRefPubMed
  18. 18.↵
    1. Sakaie KE,
    2. Shin W,
    3. Curtin KR, et al
    . Method for improving the accuracy of quantitative cerebral perfusion imaging. J Magn Reson Imaging 2005;21:512–19 doi:10.1002/jmri.20305 pmid:15834910
    CrossRefPubMed
  19. 19.↵
    1. Shin W,
    2. Cashen TA,
    3. Horowitz SW, et al
    . Quantitative CBV measurement from static T1 changes in tissue and correction for intravascular water exchange. Magn Reson Med 2006;56:138–45 doi:10.1002/mrm.20937 pmid:16767742
    CrossRefPubMed
  20. 20.↵
    1. Shin W,
    2. Horowitz S,
    3. Ragin A, et al
    . Quantitative cerebral perfusion using dynamic susceptibility contrast MRI: evaluation of reproducibility and age- and gender-dependence with fully automatic image postprocessing algorithm. Magn Reson Med 2007;58:1232–41 doi:10.1002/mrm.21420 pmid:17969025
    CrossRefPubMed
  21. 21.↵
    1. Vakil P,
    2. Lee JJ,
    3. Mouannes-Srour JJ, et al
    . Cerebrovascular occlusive disease: quantitative cerebral blood flow using dynamic susceptibility contrast MR imaging correlates with quantitative H2[15O] PET. Radiology 2013;266:879–86 doi:10.1148/radiol.12120756 pmid:23297337
    CrossRefPubMed
  22. 22.↵
    1. Systems SM
    . Absolute quantitative DSC cerebral perfusion imaging with SCALE-PWI. N4_VD13D_1049_Z00387MF_QIAN_SCALEPWI. 2015;WIP #1049.
  23. 23.↵
    T1Bookend DSC Perfusion with Global and Local AIF Open Source Code [computer program]. Version 1.2.0. Github 2024
  24. 24.↵
    1. Shah MK,
    2. Shin W,
    3. Parikh VS, et al
    . Quantitative cerebral MR perfusion imaging: preliminary results in stroke. J Magn Reson Imaging 2010;32:796–802 doi:10.1002/jmri.22302 pmid:20882609
    CrossRefPubMed
  25. 25.↵
    1. Yaghi S,
    2. Khatri P,
    3. Prabhakaran S, et al
    . What threshold defines penumbral brain tissue in patients with symptomatic anterior circulation intracranial stenosis: an exploratory analysis. J Neuroimaging 2019;29:203–05 doi:10.1111/jon.12577 pmid:30398302
    CrossRefPubMed
  26. 26.↵
    1. Calamante F,
    2. Christensen S,
    3. Desmond PM, et al
    . The physiological significance of the time-to-maximum (Tmax) parameter in perfusion MRI. Stroke 2010;41:1169–74 doi:10.1161/STROKEAHA.110.580670 pmid:20413735
    Abstract/FREE Full Text
  27. 27.↵
    1. Jones TH,
    2. Morawetz RB,
    3. Crowell RM, et al
    . Thresholds of focal cerebral ischemia in awake monkeys. J Neurosurg 1981;54:773–82 doi:10.3171/jns.1981.54.6.0773 pmid:7241187
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Nael K,
    2. Doshi A,
    3. De Leacy R, et al
    . MR perfusion to determine the status of collaterals in patients with acute ischemic stroke: a look beyond time maps. AJNR Am J Neuroradiol 2018;39:219–225 doi:10.3174/ajnr.A5454 pmid:29217747
    Abstract/FREE Full Text
  29. 29.↵
    1. Federau C,
    2. Wintermark M,
    3. Christensen S, et al
    . Collateral blood flow measurement with intravoxel incoherent motion perfusion imaging in hyperacute brain stroke. Neurology 2019;92:e2462–71 doi:10.1212/WNL.0000000000007538 pmid:31019105
    CrossRefPubMed
  30. 30.↵
    1. Liu M,
    2. Saadat N,
    3. Jeong Y, et al
    . Quantitative perfusion and water transport time model from multi b-value diffusion magnetic resonance imaging validated against neutron capture microspheres. J Med Imaging (Bellingham) 2023;10:063501doi:10.1117/1.JMI.10.6.063501
    CrossRefPubMed
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Mira M. Liu, Niloufar Saadat, Steven P. Roth, Marek A. Niekrasz, Mihai Giurcanu, Timothy J. Carroll, Gregory A. Christoforidis
Quantification of Collateral Supply with Local-AIF Dynamic Susceptibility Contrast MRI Predicts Infarct Growth
American Journal of Neuroradiology Jan 2025, DOI: 10.3174/ajnr.A8441

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Quantification of Collateral Supply with Local-AIF Dynamic Susceptibility Contrast MRI Predicts Infarct Growth
Mira M. Liu, Niloufar Saadat, Steven P. Roth, Marek A. Niekrasz, Mihai Giurcanu, Timothy J. Carroll, Gregory A. Christoforidis
American Journal of Neuroradiology Jan 2025, DOI: 10.3174/ajnr.A8441
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