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Research ArticleORIGINAL RESEARCH

Data-Driven Prognostication in Distal Medium Vessel Occlusions Using Explainable Machine Learning

Mert Karabacak, Burak Berksu Ozkara, Tobias D. Faizy, Trevor Hardigan, Jeremy J. Heit, Dhairya A. Lakhani, Konstantinos Margetis, J Mocco, Kambiz Nael, Max Wintermark and Vivek S. Yedavalli
American Journal of Neuroradiology October 2024, ajnr.A8547; DOI: https://doi.org/10.3174/ajnr.A8547
Mert Karabacak
From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
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Burak Berksu Ozkara
From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
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Tobias D. Faizy
From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
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Trevor Hardigan
From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
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Jeremy J. Heit
From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
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Dhairya A. Lakhani
From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
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Konstantinos Margetis
From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
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J Mocco
From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
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Kambiz Nael
From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
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Max Wintermark
From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
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Vivek S. Yedavalli
From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
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Article Information

ajnr.A8547
DOI 
https://doi.org/10.3174/ajnr.A8547
PubMed 
39443146

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Published online October 28, 2024.

Article Versions

  • Latest version (October 23, 2024 - 11:13).
  • You are currently viewing a Latest version of this article (October 28, 2024 - 13:56).
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Copyright & Usage 
© 2024 by American Journal of Neuroradiology

Author Information

  1. Mert Karabacak,
  2. Burak Berksu Ozkara,
  3. Tobias D. Faizy,
  4. Trevor Hardigan,
  5. Jeremy J. Heit,
  6. Dhairya A. Lakhani,
  7. Konstantinos Margetis,
  8. J Mocco,
  9. Kambiz Nael,
  10. Max Wintermark and
  11. Vivek S. Yedavalli
  1. From the Department of Neurosurgery (M.K., T.H., K.M., J.M.), and Department of Diagnostic, Molecular and Interventional Radiology (B.B.O.), Mount Sinai Health System, New York, NY, USA; Neuroendovascular Division, Department of Radiology (T.D.F.), University Medical Center Münster, Münster, Germany; Departments of Radiology and Neurosurgery (J.J.H.), Stanford University, Palo Alto, CA, USA; Department of Neuroradiology (D.A.L.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Radiology (K.N.), University of California San Francisco, San Francisco, CA, USA; Department of Neuroradiology (M.W.), MD Anderson Cancer Center, Houston, TX, USA; Russell H. Morgan Department of Radiology and Radiological Sciences (V.S.Y.), Johns Hopkins Medicine, Baltimore, MD, USA.
  1. Please address correspondence to Vivek S. Yedavalli, MD, MS, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD, 21287, USA; vyedava1{at}jhmi.edu.

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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The relative cerebral blood volume (rCBV) < 42% is independently associated with hemorrhagic transformation in anterior circulation large vessel occlusion
    Dhairya A Lakhani, Aneri B Balar, Subtain Ali, Musharaf Khan, Hamza A Salim, Manisha Koneru, Sijin Wen, Richard Wang, Janet Mei, Argye E Hillis, Jeremy J Heit, Gregory W. Albers, Adam A Dmytriw, Tobias D Faizy, Max Wintermark, Kambiz Nael, Ansaar T Rai, Vivek S Yedavalli
    Interventional Neuroradiology 2025
  • Predicting Early Outcomes of Prostatic Artery Embolization Using n-Butyl Cyanoacrylate Liquid Embolic Agent: A Machine Learning Study
    Burak Berksu Ozkara, David Bamshad, Ramita Gowda, Mert Karabacak, Vivian Bishay, Kirema Garcia-Reyes, Ardeshir R. Rastinehad, Dan Shilo, Aaron Fischman
    Diagnostics 2025 15 11
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Accepted Manuscript
Mert Karabacak, Burak Berksu Ozkara, Tobias D. Faizy, Trevor Hardigan, Jeremy J. Heit, Dhairya A. Lakhani, Konstantinos Margetis, J Mocco, Kambiz Nael, Max Wintermark, Vivek S. Yedavalli
Data-Driven Prognostication in Distal Medium Vessel Occlusions Using Explainable Machine Learning
American Journal of Neuroradiology Oct 2024, ajnr.A8547; DOI: 10.3174/ajnr.A8547

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Accepted Manuscript
Data-Driven Prognostication in Distal Medium Vessel Occlusions Using Explainable Machine Learning
Mert Karabacak, Burak Berksu Ozkara, Tobias D. Faizy, Trevor Hardigan, Jeremy J. Heit, Dhairya A. Lakhani, Konstantinos Margetis, J Mocco, Kambiz Nael, Max Wintermark, Vivek S. Yedavalli
American Journal of Neuroradiology Oct 2024, ajnr.A8547; DOI: 10.3174/ajnr.A8547
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  • Crossref (2)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The relative cerebral blood volume (rCBV) < 42% is independently associated with hemorrhagic transformation in anterior circulation large vessel occlusion
    Dhairya A Lakhani, Aneri B Balar, Subtain Ali, Musharaf Khan, Hamza A Salim, Manisha Koneru, Sijin Wen, Richard Wang, Janet Mei, Argye E Hillis, Jeremy J Heit, Gregory W. Albers, Adam A Dmytriw, Tobias D Faizy, Max Wintermark, Kambiz Nael, Ansaar T Rai, Vivek S Yedavalli
    Interventional Neuroradiology 2025
  • Predicting Early Outcomes of Prostatic Artery Embolization Using n-Butyl Cyanoacrylate Liquid Embolic Agent: A Machine Learning Study
    Burak Berksu Ozkara, David Bamshad, Ramita Gowda, Mert Karabacak, Vivian Bishay, Kirema Garcia-Reyes, Ardeshir R. Rastinehad, Dan Shilo, Aaron Fischman
    Diagnostics 2025 15 11

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