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A Neuroradiologist’s Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults
Benjamin M. Ellingson, Francesco Sanvito, Timothy F. Cloughesy, Raymond Y. Huang, Javier E. Villanueva-Meyer, Whitney B. Pope, Daniel P. Barboriak, Lalitha K. Shankar, Marion Smits, Timothy J. Kaufmann, Jerrold L. Boxerman, Michael Weller, Evanthia Galanis, John de Groot, Mark R. Gilbert, Andrew B. Lassman, Mark S. Shiroishi, Ali Nabavizadeh, Minesh Mehta, Roger Stupp, Wolfgang Wick, David A. Reardon, Michael A. Vogelbaum, Martin van den Bent, Susan M. Chang and Patrick Y. Wen
American Journal of Neuroradiology September 2024, DOI: https://doi.org/10.3174/ajnr.A8396
Benjamin M. Ellingson
aFrom the UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences (B.M.E., F.S.), David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA
Francesco Sanvito
aFrom the UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences (B.M.E., F.S.), David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA
Timothy F. Cloughesy
bUCLA Brain Tumor Program, Department of Neurology (T.F.C.), David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA
Raymond Y. Huang
cDepartment of Radiology, Brigham and Women's Hospital (R.Y.H.), Harvard Medical School, Boston, MA
Javier E. Villanueva-Meyer
dDepartments of Radiology and Neurosurgery (J.E.V.-M.), University of California San Francisco, CA
Whitney B. Pope
wDepartment of Radiological Sciences (W.B.P.), David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA
Daniel P. Barboriak
eDepartment of Radiology (D.P.B.), Duke University Medical Center, Durham, NC
Lalitha K. Shankar
fClinical Trials Branch, Cancer Imaging Program (L.K.S.), National Cancer Institute, National Institutes of Health, Bethesda, MD
Marion Smits
gDepartment of Radiology & Nuclear Medicine (M.S.), Erasmus MC - University Medical Centre Rotterdam, Rotterdam, The Netherlands
Timothy J. Kaufmann
hDepartment of Radiology (T.J.K.), Mayo Clinic, Rochester, MN
Jerrold L. Boxerman
iDepartment of Diagnostic Imaging (J.L.B.), Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI
Michael Weller
jDepartment of Neurology (M.W.), University Hospital and University of Zurich, Zurich, Switzerland
Evanthia Galanis
kDepartment of Oncology (E.G.), Mayo Clinic, Rochester, MN
John de Groot
lDivision of Neuro-Oncology, Department of Neurosurgery (J.d.G., S.M.C.), University of California, San Francisco, CA
Mark R. Gilbert
mNeuro-Oncology Branch, Center for Cancer Research (M.R.G.), National Cancer Institute, National Institutes of Health, Bethesda, MD
Andrew B. Lassman
nDivision of Neuro-Oncology, Department of Neurology (A.B.L.), Herbert Irving Comprehensive Cancer Center and Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY
Mark S. Shiroishi
oDepartment of Radiology (M.S.S.), Keck School of Medicine of the University of Southern California (USC), Los Angeles, CA
Ali Nabavizadeh
pDepartment of Radiology (A.N.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Minesh Mehta
qMiami Cancer Institute (M.M.), Miami, FL
Roger Stupp
rMalnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery, Neurology and Division of Hematology/Oncology (R.S.), Northwestern University, Chicago, IL
Wolfgang Wick
sDepartment of Neurology Heidelberg University Hospital & Clinical Cooperation Unit Neurooncology (W.W.), German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
David A. Reardon
tCenter For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School(D.A.R., P.Y.W.), Boston, MA
Michael A. Vogelbaum
uDepartment of Neuro-Oncology (M.A.V.), Moffitt Cancer Center, Tampa, FL
Martin van den Bent
vDepartment Neuro-Oncology (M.v.d.B.), Erasmus MC Cancer Institute, Rotterdam, The Netherlands
Susan M. Chang
lDivision of Neuro-Oncology, Department of Neurosurgery (J.d.G., S.M.C.), University of California, San Francisco, CA
Patrick Y. Wen
tCenter For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School(D.A.R., P.Y.W.), Boston, MA

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Benjamin M. Ellingson, Francesco Sanvito, Timothy F. Cloughesy, Raymond Y. Huang, Javier E. Villanueva-Meyer, Whitney B. Pope, Daniel P. Barboriak, Lalitha K. Shankar, Marion Smits, Timothy J. Kaufmann, Jerrold L. Boxerman, Michael Weller, Evanthia Galanis, John de Groot, Mark R. Gilbert, Andrew B. Lassman, Mark S. Shiroishi, Ali Nabavizadeh, Minesh Mehta, Roger Stupp, Wolfgang Wick, David A. Reardon, Michael A. Vogelbaum, Martin van den Bent, Susan M. Chang, Patrick Y. Wen
A Neuroradiologist’s Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults
American Journal of Neuroradiology Sep 2024, DOI: 10.3174/ajnr.A8396
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A Neuroradiologist’s Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults
Benjamin M. Ellingson, Francesco Sanvito, Timothy F. Cloughesy, Raymond Y. Huang, Javier E. Villanueva-Meyer, Whitney B. Pope, Daniel P. Barboriak, Lalitha K. Shankar, Marion Smits, Timothy J. Kaufmann, Jerrold L. Boxerman, Michael Weller, Evanthia Galanis, John de Groot, Mark R. Gilbert, Andrew B. Lassman, Mark S. Shiroishi, Ali Nabavizadeh, Minesh Mehta, Roger Stupp, Wolfgang Wick, David A. Reardon, Michael A. Vogelbaum, Martin van den Bent, Susan M. Chang, Patrick Y. Wen
American Journal of Neuroradiology Sep 2024, DOI: 10.3174/ajnr.A8396
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- Article
- Abstract
- ABBREVIATIONS:
- STANDARDIZED BRAIN TUMOR IMAGING PROTOCOL (BTIP) AND RADIOGRAPHIC READ PARADIGMS
- OVERVIEW OF UPDATES IN RANO 2.0
- DEFINITIONS OF MEASURABLE, NON-MEASURABLE, AND TARGET LESIONS (FIGURE 1)
- METHODOLOGY FOR 2D MEASUREMENTS (FIGURE 2)
- STEP-BY-STEP GUIDE TO RANO 2.0 RADIOGRAPHIC READS
- ADDITIONAL NOTES ON THE EVALUATION OF CE AND NON-CE DISEASE
- CORRESPONDENCE BETWEEN 2D AND 3D MEASUREMENTS
- CLINICAL DETERIORATION AND CORTICOSTEROID USE
- CONCLUSIONS
- Footnotes
- REFERENCES
- Figures & Data
- Supplemental
- Info & Metrics
- Responses
- References
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