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Research ArticleNEUROIMAGING PHYSICS/FUNCTIONAL NEUROIMAGING/CT AND MRI TECHNOLOGY

Asymmetry of the Frontal Aslant Tract Depends on Handedness

Mohammad Taghvaei, Craig K. Jones, Licia P. Luna, Sachin K. Gujar and Haris I. Sair
American Journal of Neuroradiology July 2024, DOI: https://doi.org/10.3174/ajnr.A8270
Mohammad Taghvaei
aFrom the Department of Neurology (M.T.), University of Pennsylvania, Philadelphia, Pennsylvania
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  • ORCID record for Mohammad Taghvaei
Craig K. Jones
bDepartment of Computer Science (C.K.J.), The Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland
cThe Malone Center for Engineering in Healthcare (C.K.J., H.I.S.), The Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland
dThe Russell. H. Morgan Department of Radiology and Radiological Science (C.K.J., L.P.L., S.K.G., H.I.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland
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Licia P. Luna
dThe Russell. H. Morgan Department of Radiology and Radiological Science (C.K.J., L.P.L., S.K.G., H.I.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland
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Sachin K. Gujar
dThe Russell. H. Morgan Department of Radiology and Radiological Science (C.K.J., L.P.L., S.K.G., H.I.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland
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Haris I. Sair
cThe Malone Center for Engineering in Healthcare (C.K.J., H.I.S.), The Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland
dThe Russell. H. Morgan Department of Radiology and Radiological Science (C.K.J., L.P.L., S.K.G., H.I.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • FIG 1.
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    FIG 1.

    Comparing left and right FAT parameters in each handedness group. Significant differences (FDR-corrected P < .05), after controlling for age, sex, and ICV, are indicated with asterisks. The error bars represent 95% CIs.

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    FIG 2.

    Comparing the LI of macrostructural parameters across handedness groups. Significant differences (FDR-corrected P < .05), after controlling for age, sex, and ICV, are indicated with asterisks. The error bars represent 95% CIs.

  • FIG 3.
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    FIG 3.

    A, The right and left FAT in a sample RH subject (EHI: +100) demonstrating left-side dominance in FAT volume. B, Right and left FAT in a sample LH subject (EHI: −70) demonstrating right-side dominance in FAT volume. L indicates left; R, right.

Tables

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    Table 1:

    Comparing FAT parameters across sex groups, controlling for age and ICV

    Left FATRight FAT
    Female, Mean (SD) (n = 404)Male, Mean (SD) (n = 316)P ValueFemale, Mean (SD) (n = 404)Male, Mean (SD) (n = 316)P Value
    No. of streamlines15,891.4 (1959.0)17,818.0 (2031.5).003a,b16,041.1 (1950.3)17,854.4 (2199.8).033a
    Volume (mm3)15,678.8 (2690.0)17,808.7 (2934.8).002b15,374.0 (2692.0)17,451.1 (3062.8).001a,b
    Length (mm)74.26 (3.46)77.40 (3.27).38673.55 (3.43)76.75 (3.00).073
    Diameter (mm)16.33 (1.33)17.06 (1.33).003a,b16.24 (1.33)16.94 (1.42).004a,b
    FA0.413 (0.026)0.413 (0.024).9020.402 (0.025)0.403 (0.023).287
    MD0.678 (0.033)0.680 (0.035).7910.683 (0.034)0.682 (0.033).423
    AD0.995 (0.037)0.995 (0.037).6970.992 (0.037)0.991 (0.036).435
    RD0.520 (0.035)0.522 (0.036).5630.527 (0.035)0.528 (0.034).474
    • ↵a Statistically significant results.

    • ↵b Significant P value after FDR correction for multiple comparisons.

    • View popup
    Table 2:

    Macrostructural and microstructural differences between right- and left-sided FAT

    Left FAT, Mean (SD)Right FAT, Mean (SD)P Value
    No. of streamlines16,736.9 (2207.8)16,836.9 (2250.1).157
    Volume (mm3)16,613.6 (2992.2)16,285.6 (3039.0).003a,b
    Length (mm)75.64 (3.72)74.95 (3.62)<.001a,b
    Diameter (mm)16.65 (1.37)16.55 (1.41).064
    FA0.413 (0.025)0.403 (0.024)<.001a,b
    MD0.679 (0.034)0.682 (0.033)<.001a,b
    AD0.995 (0.037)0.991 (0.036)<.001a,b
    RD0.521 (0.036)0.528 (0.035)<.001a,b
    • ↵a Statistically significant results.

    • ↵b Significant P value after FDR correction for multiple comparisons.

    • View popup
    Table 3:

    Comparison of FAT parameters across handedness groups

    Right-Handedness (n = 612)Left-Handedness (n = 55)
    Left FAT Mean (SD)Right FAT Mean (SD)P ValueLeft FAT Mean (SD)Right FAT Mean (SD)P Value
    No. of streamlines16,705.3 (2235.0)16,777.4 (2218.3).34916,905.2 (1981.7)17,279.1 (2363.9).123
    Volume (mm3)16,614.8 (2928.6)16,152.7 (3005.7)<.001a,b16,330.6 (3653.7)17,200.4 (2957.5).040a
    Length (mm)75.57 (3.72)74.88 (3.61)<.001a,b76.36 (3.62)75.97 (3.40).293
    Diameter (mm)16.66 (1.34)16.49 (1.41).004a,b16.38 (1.77)16.87 (1.35).032a
    FA0.413 (0.025)0.403 (0.024)<.001a,b0.409 (0.023)0.399 (0.021)<.001a,b
    MD0.679 (0.034)0.682 (0.033)<.001a,b0.688 (0.036)0.693 (0.032).006a,b
    AD0.995 (0.037)0.991 (0.036)<.001a,b1.00 (0.041)1.00 (0.036).916
    RD0.521 (0.035)0.528 (0.035)<.001a,b0.530 (0.036)0.538 (0.033)<.001a,b
    • ↵a Statistically significant results.

    • ↵b Significant P value after FDR correction for multiple comparisons.

    • View popup
    Table 4:

    Comparison LI across handedness groups

    LIRight-Handedness (n = 612)aLeft-Handedness (n = 55)aP Value
    No. of streamlines+0.51 (5.78)+1.27 (5.20).273
    Volume (mm3)–1.50 (8.96)+3.19 (10.55).001b,c
    Length (mm)–0.46 (1.82)–0.25 (1.79).414
    Diameter (mm)–0.53 (4.40)+1.59 (5.24)<.001b,c
    FA–1.27 (1.83)–1.21 (1.86).844
    MD+0.24 (0.93)+0.38 (0.95).231
    AD–0.20 (1.01)–0.00 (0.093).137
    RD+0.66 (1.43)+0.74 (1.47).531
    • ↵a Data are presented as mean (SD).

    • ↵b Statistically significant results.

    • ↵c Significant P value after FDR correction for multiple comparisons.

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Mohammad Taghvaei, Craig K. Jones, Licia P. Luna, Sachin K. Gujar, Haris I. Sair
Asymmetry of the Frontal Aslant Tract Depends on Handedness
American Journal of Neuroradiology Jul 2024, DOI: 10.3174/ajnr.A8270

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Asymmetry of the Frontal Aslant Tract Depends on Handedness
Mohammad Taghvaei, Craig K. Jones, Licia P. Luna, Sachin K. Gujar, Haris I. Sair
American Journal of Neuroradiology Jul 2024, DOI: 10.3174/ajnr.A8270
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