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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleSPINE IMAGING AND SPINE IMAGE-GUIDED INTERVENTIONS

Application of Spinal Subtraction and Bone Background Fusion CTA in the Accurate Diagnosis and Evaluation of Spinal Vascular Malformations

Xuehan Hu, Zhidong Yuan, Kaiyin Liang, Min Chen, Zhen Zhang, Hairong Zheng and Guanxun Cheng
American Journal of Neuroradiology February 2024, DOI: https://doi.org/10.3174/ajnr.A8112
Xuehan Hu
aFrom the Department of Radiology (X.H., Z.Y., K.L., Z.Z., G.C.), Peking University Shenzhen Hospital, Shenzhen, China
bPaul C. Lauterbur Research Center for Biomedical Imaging (X.H., H.Z.), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
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  • ORCID record for Xuehan Hu
Zhidong Yuan
aFrom the Department of Radiology (X.H., Z.Y., K.L., Z.Z., G.C.), Peking University Shenzhen Hospital, Shenzhen, China
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Kaiyin Liang
aFrom the Department of Radiology (X.H., Z.Y., K.L., Z.Z., G.C.), Peking University Shenzhen Hospital, Shenzhen, China
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Min Chen
cDepartment of Radiology (M.C.), Southern University of Science and Technology Hospital, Shenzhen, China
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Zhen Zhang
aFrom the Department of Radiology (X.H., Z.Y., K.L., Z.Z., G.C.), Peking University Shenzhen Hospital, Shenzhen, China
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Hairong Zheng
bPaul C. Lauterbur Research Center for Biomedical Imaging (X.H., H.Z.), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
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Guanxun Cheng
aFrom the Department of Radiology (X.H., Z.Y., K.L., Z.Z., G.C.), Peking University Shenzhen Hospital, Shenzhen, China
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  • Article
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Article Figures & Data

Figures

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  • FIG 1.
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    FIG 1.

    Flow chart of the patient enrollment process and workflow of this study. Asterisk indicates accurate localization of critical lesions which defined as mostly correct when multiple feeding arteries are present, and the identification of drainage veins covering over 70% of the range.

  • FIG 2.
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    FIG 2.

    Percentage of stacked bar chart of categorization of postprocessing SSBBF reconstruction accuracy. Types 3 and 4 are considered particularly beneficial in aiding clinical diagnosis and treatment.

  • FIG 3.
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    FIG 3.

    Spinal CTA images in a 28-year-old man with a spinal AVM. The crucial lesions, including nidus (arrowhead), feeding artery (solid arrow), and drainage vein (dotted arrow), are shown in MPR-CTA (A), RBS-CTA (B), SSBBF-CTA (C), and DSA images (D).

  • FIG 4.
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    FIG 4.

    Spinal CTA images in a 55-year-old woman with a spinal AVF. The crucial lesions, including the fistula (arrowhead), feeding artery (solid arrow), and drainage vein (dotted arrow), are shown in an MPR-CTA image (A), a RBS-CTA image (B), SSBBF-CTA image (C), and a DSA image (D).

Tables

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    Table 1:

    Patient characteristicsa

    Group AGroup BP Value
    Age (yr)b44.0 (SD, 14.3)44.6 (SD, 15.2).898
    Sexc.990
     Female911
     Male1316
    Sensory disturbance100% (22/22)88.9% (24/27).242
    Motor disturbance90.9% (20/22)77.8% (21/27).269
    Reflex abnormality68.2% (15/22)66.7% (18/27).910
    Urogenital disturbance72.7% (16/22)33.3% (9/27).005d
    Back pain9.1% (2/22)11.1% (3/27)1.000
    • ↵a Unless otherwise indicated, data are percentages, with numbers of patients in parentheses.

    • ↵b Age is presented as the mean.

    • ↵c Data are numbers of patients.

    • ↵d The clinical features of groups A and B showed statistically significant differences (P < .05).

    • View popup
    Table 2:

    Diagnostic efficacy of original images with MPR for primary screening of SVMs by different readersa

    ReaderSensitivity (%)Specificity (%)Accuracy (%)PPV (%)NPV (%)AUC [95% CI]Youden
    Reader 1b77.3 (17/22)92.6 (25/27)85.7 (42/49)89.5 (17/19)83.3 (25/30)0.849 (0.718–0.935)0.699
    Reader 290.9 (20/22)96.3 (26/27)93.9 (46/49)95.2 (20/21)92.9 (26/28)0.936 (0.828–0.986)0.872
    Reader 395.5 (21/22)100 (27/27)98.0 (48/49)100 (21/21)96.4 (27/28)0.977 (0.888–0.999)0.955
    • Note:—PPV indicates positive predictive value; NPV, negative predictive value; Reader 1, a radiologist with one year of experience; Reader 2, a junior physician who submitted the original report for the first time;Reader 3, a reviewing physician who also submitted the original report for the first time.

    • ↵a Data in brackets are 95% CIs, and data in parentheses are numbers of patients.

    • ↵b Readers 1 and 3 showed statistically significant differences (P < .05).

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    Table 3:

    Scoring of lesion localization and visualization of SVMs using different postprocessing techniques of CTA imagesa

    MPR-CTARBS-CTAbSSBBF-CTAP Valuec
    Visualization of lesions (total points)6.00 (1.00)4.00 (2.75)6.00 (0.63).000
     Nidus/fistula2.00 (0.00)1.50 (1.00)2.00 (1.25).000
     Feeding artery2.00 (0.63)1.00 (1.50)2.00 (0.00).000
     Drainage vein2.00 (0.00)1.00 (1.00)2.00 (0.00).000
    Localization of lesions (total points)6.00 (0.00)3.25 (3.00)6.00 (1.00).000
     Nidus/fistula2.00 (0.00)1.00 (1.00)2.00 (0.00).000
     Feeding artery2.00 (0.00)1.00 (2.00)2.00 (0.00).000
     Drainage vein2.00 (0.00)1.00 (1.13)2.00 (0.00).00
    Overall morphology4.00 (0.00)2.75 (2.63)4.00 (0.50).000
    • ↵a The data are presented as median (interquartile range).

    • b There is a statistically significant difference between RBS-CTA and the other 2 groups (P < .05).

    • c There is a significant statistical difference among the 3 groups (P < .05).

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    Table 4:

    Assessment of lesions of SVMs and diagnostic time using different postprocessing CTA techniques by different readersa

    Reader 1Reader 4P Value
    MPR-CTA
     Visualization of lesions4.00 (1.25)6.00 (1.00).001b
     Localization of lesions4.50 (2.00)6.00 (0.00).003b
     Overall morphology4.00 (1.00)4.00 (0.00).025b
     Diagnostic time9.00 (6.75)7.00 (3.00).017b
    RBS-CTA
     Visualization of lesions3.50 (3.00)3.50 (3.00).353
     Localization of lesions2.25 (3.00)3.00 (2.50).178
     Overall morphology2.50 (1.25)3.00 (2.00).070
     Diagnostic timeNANANA
    SSBBF-CTA
     Visualization of lesions6.00 (1.00)6.00 (1.00).705
     Localization of lesions6.00 (1.00)6.00 (1.00).206
     Overall morphology4.00 (0.25)4.00 (0.13).655
     Diagnostic time3.00 (2.00)c3.00 (1.25)c.943
    • Note:—NA indicates not applicable; Reader 1, a radiologist with one year of experience; Reader 4, a radiologist with 4 years of experience.

    • a The data are presented as median (interquartile range). The visualization and localization of lesions represent the total score of the nidus/fistula, feeding artery, and drainage vein.

    • ↵b There is a significant statistical difference between readers 1 and 4 (P < .05).

    • ↵c There is a statistically significant difference in diagnostic time between the use of MPR-CTA and SSBBF-CTA (P = .000).

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Application of Spinal Subtraction and Bone Background Fusion CTA in the Accurate Diagnosis and Evaluation of Spinal Vascular Malformations
Xuehan Hu, Zhidong Yuan, Kaiyin Liang, Min Chen, Zhen Zhang, Hairong Zheng, Guanxun Cheng
American Journal of Neuroradiology Feb 2024, DOI: 10.3174/ajnr.A8112
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Xuehan Hu, Zhidong Yuan, Kaiyin Liang, Min Chen, Zhen Zhang, Hairong Zheng, Guanxun Cheng
Application of Spinal Subtraction and Bone Background Fusion CTA in the Accurate Diagnosis and Evaluation of Spinal Vascular Malformations
American Journal of Neuroradiology Feb 2024, DOI: 10.3174/ajnr.A8112

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