Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePEDIATRIC NEUROIMAGING

Clinical and Imaging Findings in Children with Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD): From Presentation to Relapse

Elizabeth George, Jeffrey B. Russ, Alexandria Validrighi, Heather Early, Mark D. Mamlouk, Orit A. Glenn, Carla M. Francisco, Emmanuelle Waubant, Camilla Lindan and Yi Li
American Journal of Neuroradiology January 2024, DOI: https://doi.org/10.3174/ajnr.A8089
Elizabeth George
aFrom the Department of Radiology and Biomedical Imaging (E.G., O.A.G., C.L., Y.L.), University of California San Francisco, San Francisco, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Elizabeth George
Jeffrey B. Russ
bDepartment of Pediatrics (J.B.R.), Division of Neurology, Duke University, Durham, North Carolina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jeffrey B. Russ
Alexandria Validrighi
cDivision of Child Neurology (A.V.), Department of Neurology, University of California San Francisco, San Francisco, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Alexandria Validrighi
Heather Early
dDepartment of Radiology (H.E.), University of Texas Southwestern, Dallas, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark D. Mamlouk
ePermanente Medical Group (M.D.M.), Kaiser Permanente Medical Center Santa Clara, Santa Clara, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Mark D. Mamlouk
Orit A. Glenn
aFrom the Department of Radiology and Biomedical Imaging (E.G., O.A.G., C.L., Y.L.), University of California San Francisco, San Francisco, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Orit A. Glenn
Carla M. Francisco
fDepartment of Neurology (C.M.F., E.W.), University of California San Francisco, San Francisco, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Carla M. Francisco
Emmanuelle Waubant
fDepartment of Neurology (C.M.F., E.W.), University of California San Francisco, San Francisco, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Camilla Lindan
aFrom the Department of Radiology and Biomedical Imaging (E.G., O.A.G., C.L., Y.L.), University of California San Francisco, San Francisco, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Camilla Lindan
Yi Li
aFrom the Department of Radiology and Biomedical Imaging (E.G., O.A.G., C.L., Y.L.), University of California San Francisco, San Francisco, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yi Li
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

REFERENCES

  1. 1.↵
    1. O’Connor KC,
    2. McLaughlin KA,
    3. De Jager PL, et al
    . Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med 2007;13:211–17 doi:10.1038/nm1488 pmid:17237795
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Reindl M,
    2. Waters P
    . Myelin oligodendrocyte glycoprotein antibodies in neurological disease. Nat Rev Neurol 2019;15:89–102 doi:10.1038/s41582-018-0112-x pmid:30559466
    CrossRefPubMed
  3. 3.↵
    1. de Mol CL,
    2. Wong YY,
    3. van Pelt ED, et al
    . Incidence and outcome of acquired demyelinating syndromes in Dutch children: update of a nationwide and prospective study. J Neurol 2018;265:1310–19 doi:10.1007/s00415-018-8835-6 pmid:29569176
    CrossRefPubMed
  4. 4.↵
    1. Hennes EM,
    2. Baumann M,
    3. Schanda K
    , BIOMARKER Study Group, et al. Prognostic relevance of MOG antibodies in children with an acquired demyelinating syndrome. Neurology 2017;89:900–08 doi:10.1212/WNL.0000000000004312 pmid:28768844
    CrossRefPubMed
  5. 5.↵
    1. Hacohen Y,
    2. Wong YY,
    3. Lechner C, et al
    . Disease course and treatment responses in children with relapsing myelin oligodendrocyte glycoprotein antibody-associated disease. JAMA Neurol 2018;75:478–87 doi:10.1001/jamaneurol.2017.4601 pmid:29305608
    CrossRefPubMed
  6. 6.↵
    1. Hacohen Y,
    2. Banwell B
    . Treatment approaches for MOG-Ab-associated demyelination in children. Curr Treat Options Neurol 2019;21:2 doi:10.1007/s11940-019-0541-x pmid:30671648
    CrossRefPubMed
  7. 7.↵
    1. Lopez-Chiriboga AS,
    2. Majed M,
    3. Fryer J, et al
    . Association of MOG-IgG serostatus with relapse after acute disseminated encephalomyelitis and proposed diagnostic criteria for MOG-IgG-associated disorders. JAMA Neurol 2018;75:1355–63 doi:10.1001/jamaneurol.2018.1814 pmid:30014148
    CrossRefPubMed
  8. 8.↵
    1. Jarius S,
    2. Ruprecht K,
    3. Kleiter I
    , Neuromyelitis Optica Study Group (NEMOS), et al. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. 1. Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin. J Neuroinflammation 2016;13:279 doi:10.1186/s12974-016-0717-1 pmid:27788675
    CrossRefPubMed
  9. 9.↵
    1. Armangue T,
    2. Olive-Cirera G,
    3. Martinez-Hernandez E
    , Spanish Pediatric anti-MOG Study Group, et al. Associations of paediatric demyelinating and encephalitic syndromes with myelin oligodendrocyte glycoprotein antibodies: a multicentre observational study. Lancet Neurol 2020;19:234–46 doi:10.1016/S1474-4422(19)30488-0 pmid:32057303
    CrossRefPubMed
  10. 10.↵
    1. Fernandez-Carbonell C,
    2. Vargas-Lowy D,
    3. Musallam A, et al
    . Clinical and MRI phenotype of children with MOG antibodies. Mult Scler 2016;22:174–84 doi:10.1177/1352458515587751 pmid:26041801
    CrossRefPubMed
  11. 11.↵
    1. Wegener-Panzer A,
    2. Cleaveland R,
    3. Wendel EM, et al
    . Clinical and imaging features of children with autoimmune encephalitis and MOG antibodies. Neurol Neuroimmunol Neuroinflamm 2020;7:e731 doi:10.1212/NXI.0000000000000731
    Abstract/FREE Full Text
  12. 12.↵
    1. Hennes EM,
    2. Baumann M,
    3. Lechner C, et al
    . MOG spectrum disorders and role of MOG-antibodies in clinical practice. Neuropediatrics 2018;49:3–11 doi:10.1055/s-0037-1604404 pmid:28859212
    CrossRefPubMed
  13. 13.↵
    1. Xu J,
    2. Liu L,
    3. Xiong J, et al
    . The clinical, radiologic, and prognostic differences between pediatric and adult patients with myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis. Front Neurol 2021;12:679430 doi:10.3389/fneur.2021.679430 pmid:34093424
    CrossRefPubMed
  14. 14.↵
    1. Baumann M,
    2. Bartels F,
    3. Finke C
    , E.U. Paediatric MOG Consortium, et al. E.U. Paediatric MOG Consortium Consensus: 2. Neuroimaging features of paediatric myelin oligodendrocyte glycoprotein antibody-associated disorders. Eur J Paediatr Neurol 2020;29:14–21 doi:10.1016/j.ejpn.2020.10.002 pmid:33158737
    CrossRefPubMed
  15. 15.↵
    1. Baumann M,
    2. Grams A,
    3. Djurdjevic T, et al
    . MRI of the first event in pediatric acquired demyelinating syndromes with antibodies to myelin oligodendrocyte glycoprotein. J Neurol 2018;265:845–55 doi:10.1007/s00415-018-8781-3 pmid:29423614
    CrossRefPubMed
  16. 16.↵
    1. Baumann M,
    2. Sahin K,
    3. Lechner C, et al
    . Clinical and neuroradiological differences of paediatric acute disseminating encephalomyelitis with and without antibodies to the myelin oligodendrocyte glycoprotein. J Neurol Neurosurg Psychiatry 2015;86:265–72 doi:10.1136/jnnp-2014-308346 pmid:25121570
    Abstract/FREE Full Text
  17. 17.↵
    1. Konuskan B,
    2. Yildirim M,
    3. Gocmen R, et al
    . Retrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders. Mult Scler Relat Disord 2018;26:1–7 doi:10.1016/j.msard.2018.07.022 pmid:30212767
    CrossRefPubMed
  18. 18.↵
    1. Banwell B,
    2. Bennett JL,
    3. Marignier R, et al
    . Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria. Lancet Neurol 2023;22:268–82 doi:10.1016/S1474-4422(22)00431-8 pmid:36706773
    CrossRefPubMed
  19. 19.↵
    1. Lui A,
    2. Chong J,
    3. Flanagan E, et al
    . High titers of myelin oligodendrocyte glycoprotein antibody are only observed close to clinical events in pediatrics. Mult Scler Relat Disord 2021;56:103253 doi:10.1016/j.msard.2021.103253 pmid:34517190
    CrossRefPubMed
  20. 20.↵
    1. Tantsis EM,
    2. Prelog K,
    3. Alper G
    , Paediatric Myelitis MRI Study Group, et al. Magnetic resonance imaging in enterovirus-71, myelin oligodendrocyte glycoprotein antibody, aquaporin-4 antibody, and multiple sclerosis-associated myelitis in children. Dev Med Child Neurol 2019;61:1108–16 doi:10.1111/dmcn.14114 pmid:30537075
    CrossRefPubMed
  21. 21.↵
    1. Salama S,
    2. Khan M,
    3. Levy M, et al
    . Radiological characteristics of myelin oligodendrocyte glycoprotein antibody disease. Mult Scler Relat Disord 2019;29:15–22 doi:10.1016/j.msard.2019.01.021 pmid:30658259
    CrossRefPubMed
  22. 22.↵
    1. Dubey D,
    2. Pittock SJ,
    3. Krecke KN, et al
    . Clinical, radiologic, and prognostic features of myelitis associated with myelin oligodendrocyte glycoprotein autoantibody. JAMA Neurol 2019;76:301–09 doi:10.1001/jamaneurol.2018.4053 pmid:30575890
    CrossRefPubMed
  23. 23.↵
    1. Cobo-Calvo A,
    2. Ruiz A,
    3. D’Indy H, et al
    . MOG antibody-related disorders: common features and uncommon presentations. J Neurol 2017;264:1945–55 doi:10.1007/s00415-017-8583-z pmid:28770374
    CrossRefPubMed
  24. 24.↵
    1. Garbugio Dutra B,
    2. da Rocha AJ,
    3. Hoffmann Nunes R, et al
    . Neuromyelitis optica spectrum disorders: spectrum of MR imaging findings and their differential diagnosis. Radiographics 2018;38:169–193 doi:10.1148/rg.2018184002 pmid:29528835
    CrossRefPubMed
  25. 25.↵
    1. Song H,
    2. Zhou H,
    3. Yang M, et al
    . Clinical characteristics and outcomes of myelin oligodendrocyte glycoprotein antibody-seropositive optic neuritis in varying age groups: a cohort study in China. J Neurol Sci 2019;400:83–89 doi:10.1016/j.jns.2019.03.014 pmid:30904690
    CrossRefPubMed
  26. 26.↵
    1. Wendel EM,
    2. Baumann M,
    3. Barisic N, et al
    . High association of MOG-IgG antibodies in children with bilateral optic neuritis. Eur J Paediatr Neurol 2020;27:86–93 doi:10.1016/j.ejpn.2020.04.002 pmid:32327391
    CrossRefPubMed
  27. 27.↵
    1. Sato DK,
    2. Callegaro D,
    3. Lana-Peixoto MA, et al
    . Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders. Neurology 2014;82:474–81 doi:10.1212/WNL.0000000000000101 pmid:24415568
    Abstract/FREE Full Text
  28. 28.↵
    1. Kitley J,
    2. Waters P,
    3. Woodhall M, et al
    . Neuromyelitis optica spectrum disorders with aquaporin-4 and myelin-oligodendrocyte glycoprotein antibodies: a comparative study. JAMA Neurol 2014;71:276–83 doi:10.1001/jamaneurol.2013.5857 pmid:24425068
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Wang C,
    2. Narayan R,
    3. Greenberg B
    . Anti-myelin oligodendrocyte glycoprotein antibody associated with gray matter predominant transverse myelitis mimicking acute flaccid myelitis: a presentation of two cases. Pediatr Neurol 2018;86:42–45 doi:10.1016/j.pediatrneurol.2018.06.003 pmid:30077551
    CrossRefPubMed
  30. 30.↵
    1. Ramanathan S,
    2. Mohammad S,
    3. Tantsis E
    , Australasian and New Zealand MOG Study Group, et al. Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination. J Neurol Neurosurg Psychiatry 2018;89:127–37 doi:10.1136/jnnp-2017-316880 pmid:29142145
    Abstract/FREE Full Text
  31. 31.↵
    1. Waters P,
    2. Fadda G,
    3. Woodhall M
    , Canadian Pediatric Demyelinating Disease Network, et al. Serial anti-myelin oligodendrocyte glycoprotein antibody analyses and outcomes in children with demyelinating syndromes. JAMA Neurol 2020;77:82–93 doi:10.1001/jamaneurol.2019.2940 pmid:31545352
    CrossRefPubMed
PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Clinical and Imaging Findings in Children with Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD): From Presentation to Relapse
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Elizabeth George, Jeffrey B. Russ, Alexandria Validrighi, Heather Early, Mark D. Mamlouk, Orit A. Glenn, Carla M. Francisco, Emmanuelle Waubant, Camilla Lindan, Yi Li
Clinical and Imaging Findings in Children with Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD): From Presentation to Relapse
American Journal of Neuroradiology Jan 2024, DOI: 10.3174/ajnr.A8089

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Clinical and Imaging Findings in Children with Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD): From Presentation to Relapse
Elizabeth George, Jeffrey B. Russ, Alexandria Validrighi, Heather Early, Mark D. Mamlouk, Orit A. Glenn, Carla M. Francisco, Emmanuelle Waubant, Camilla Lindan, Yi Li
American Journal of Neuroradiology Jan 2024, DOI: 10.3174/ajnr.A8089
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref (4)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Radiological features in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease—diagnostic criteria and lesion dynamics
    Li-tal Pratt, Hadas Meirson, Mika Shapira Rootman, Liat Ben-Sira, Shelly I Shiran
    Pediatric Radiology 2024 55 4
  • Typical and Emerging Diagnostic MRI Features in Multiple Sclerosis
    Àlex Rovira, Cristina Auger, Sofía Sceppacuercia, Carlos Torres
    Canadian Association of Radiologists Journal 2025 76 1
  • Clinico-investigational profile, relapse predictors and outcomes of pediatric patients with anti-myelin oligodendrocyte associated disorders: An experience from tertiary centre
    Debjyoti Dhar, Subhajit Roy, Raghavendra Kenchaiah, Mahammad Samim Mondal, Seetam Kumar, Saraswati Nashi, Shilpa Rao, Rashmi Santhoshkumar, Rohan Mahale, Nagaraj AR, Sahil Mathur, Pooja Mailankody, Maya Dattatraya Bhat, Anita Mahadevan, Hansashree Padmanabha
    Multiple Sclerosis and Related Disorders 2025 97
  • Optikusneuritis – Patient sieht nichts, Arzt sieht nichts?
    Lisa Julia Müller, Jasmin Naumann, Gesine Szurman, Karl T. Boden, Peter Szurman, André Maurice Trouvain, Annekatrin Rickmann
    Die Ophthalmologie 2025

More in this TOC Section

  • Neuroimaging Delineation and Progression of SLSMD
  • fetal brain development of 10 weeks gestation
  • CHARGE fetal MRI clival cleft
Show more Pediatric Neuroimaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire