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Research ArticleSPINE IMAGING AND SPINE IMAGE-GUIDED INTERVENTIONS

Lateral Decubitus Dynamic CT Myelography with Real-Time Bolus Tracking (dCTM-BT) for Evaluation of CSF-Venous Fistulas: Diagnostic Yield Stratified by Brain Imaging Findings

Thien J. Huynh, Donna Parizadeh, Ahmed K. Ahmed, Christopher T. Gandia, Hal C. Davison, John V. Murray, Ian T. Mark, Ajay A. Madhavan, Darya Shlapak, Todd D. Rozen, Waleed Brinjikji, Prasanna Vibhute, Vivek Gupta, Kacie Brewer and Olga Fermo
American Journal of Neuroradiology December 2023, DOI: https://doi.org/10.3174/ajnr.A8082
Thien J. Huynh
aFrom the Department of Radiology (T.J.H., D.P., A.K.A., C.T.G., H.C.D., J.V.M., P.V., V.G., K.B.), Mayo Clinic, Jacksonville, Florida
dDepartment of Neurosurgery (T.J.H.), Mayo Clinic, Jacksonville, Florida
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Donna Parizadeh
aFrom the Department of Radiology (T.J.H., D.P., A.K.A., C.T.G., H.C.D., J.V.M., P.V., V.G., K.B.), Mayo Clinic, Jacksonville, Florida
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Ahmed K. Ahmed
aFrom the Department of Radiology (T.J.H., D.P., A.K.A., C.T.G., H.C.D., J.V.M., P.V., V.G., K.B.), Mayo Clinic, Jacksonville, Florida
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Christopher T. Gandia
aFrom the Department of Radiology (T.J.H., D.P., A.K.A., C.T.G., H.C.D., J.V.M., P.V., V.G., K.B.), Mayo Clinic, Jacksonville, Florida
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Hal C. Davison
aFrom the Department of Radiology (T.J.H., D.P., A.K.A., C.T.G., H.C.D., J.V.M., P.V., V.G., K.B.), Mayo Clinic, Jacksonville, Florida
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John V. Murray
aFrom the Department of Radiology (T.J.H., D.P., A.K.A., C.T.G., H.C.D., J.V.M., P.V., V.G., K.B.), Mayo Clinic, Jacksonville, Florida
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Ian T. Mark
cDepartment of Radiology (I.T.M., A.A.M., D.S., W.B.), Mayo Clinic, Rochester, Minnesota.
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Ajay A. Madhavan
cDepartment of Radiology (I.T.M., A.A.M., D.S., W.B.), Mayo Clinic, Rochester, Minnesota.
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Darya Shlapak
cDepartment of Radiology (I.T.M., A.A.M., D.S., W.B.), Mayo Clinic, Rochester, Minnesota.
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Todd D. Rozen
bDepartment of Neurology (T.D.R., O.F.), Mayo Clinic, Jacksonville, Florida
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Waleed Brinjikji
cDepartment of Radiology (I.T.M., A.A.M., D.S., W.B.), Mayo Clinic, Rochester, Minnesota.
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Prasanna Vibhute
aFrom the Department of Radiology (T.J.H., D.P., A.K.A., C.T.G., H.C.D., J.V.M., P.V., V.G., K.B.), Mayo Clinic, Jacksonville, Florida
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Vivek Gupta
aFrom the Department of Radiology (T.J.H., D.P., A.K.A., C.T.G., H.C.D., J.V.M., P.V., V.G., K.B.), Mayo Clinic, Jacksonville, Florida
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Kacie Brewer
aFrom the Department of Radiology (T.J.H., D.P., A.K.A., C.T.G., H.C.D., J.V.M., P.V., V.G., K.B.), Mayo Clinic, Jacksonville, Florida
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Olga Fermo
bDepartment of Neurology (T.D.R., O.F.), Mayo Clinic, Jacksonville, Florida
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  • FIG 1.
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    FIG 1.

    Lateral decubitus dynamic CT myelogram with real-time contrast bolus tracking (dCTM-BT): A, Frontal CT scout image shows patient in the left lateral decubitus position on the CT gantry table, with the hips placed at the apex of a custom firm foam wedge in the Trendelenburg position, at an angle of approximately 10°, to facilitate the caudocranial flow of contrast from the lumbar puncture towards the cervical spine. B–D, Real-time contrast bolus monitoring axial scans at the level of T5 (A, dashed line) with axial slices taken at 5-second intervals until the visualization of dense contrast (D, arrow). Note that dense contrast visualization is typically observed immediately after the initial appearance of contrast (C, arrow). E, Graph of density (Hounsfield units, HU) of monitored contrast bolus over time (region of interest placed at arrow in panels C and D; note that this graph is for illustrative purposes and is not utilized during the procedure). F, Axial CT myelogram showing the contrast enhancement of the paraspinal veins at the left T10, indicating a CSF-venous fistula (F, arrowheads).

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    FIG 2.

    Axial images from a right lateral decubitus dynamic CT myelogram with bolus-tracking that were acquired at 30 seconds (A), 60 seconds (B), 2 minutes (C), and 4 minutes (D) after dense contrast was visualized on the bolus-tracking. A CSF-venous fistula is clearly identified on the image acquired at 2 minutes, with contrast visualized in a right T7 paraspinal vein (C, arrowheads). Note that the CVF only becomes more prominent after the adjacent diverticulum has nearly been completely filled with contrast.

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    FIG 3.

    Bar chart illustrating the number of patients with CVF identified on dCTM-BT, across Bern SIH scores. The Bern SIH score was calculated based on the brain MRI, categorizing the probability of a spinal CSF leak as low (score of 0–2), intermediate (score of 3–4), or high (score of 5–9).

Tables

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  • Patient and imaging characteristics with and without CSF-venous fistulaa

    Total (n = 48)CVF Absent (n = 25)CVF Present (n = 23)P Value
    Patient characteristics
     Age, mean (SD)54 (12.0)48 (11.5)60 (9.7)<.001
     Female37 (77.1)18 (72.0)19 (83).38
     Orthostatic/Valsalva headache35 (72.9)17 (68)18 (78).42
    CVF characteristics
     Right side16 (70)
     CVF level
     T1–T54 (17%)
     T6–T1218 (78%)
     L11 (4%)
    MRI brain SIH findings
     Engorgement of venous sinus21 (44)0 (0)21 (91)<.001
     Pachymeningeal enhancement21 (44)0 (0)21 (91)<.001
     Suprasellar cistern effacement26 (54)7 (28)19 (83)<.001
     Subdural fluid collection1 (2)0 (0)1 (4.3).48
     Prepontine cistern effacement35 (73)13 (52)22 (96)<.001
     Decreased mamillopontine distance33 (69)12 (48)21 (91).001
     Bern SIH Score4 (1–8)1 (0–3)8 (6–8)<.001
    Bern SIH score category
     Low19 (40)19 (76)0 (0)
     Intermediate7 (15)6 (24)1 (4)
     High22 (46)0 (0)22 (96)
    • ↵a For the categoric variables, the data are presented as n (%) and are compared between groups via χ2 or Fisher exact tests. For the continuous variables, the age is reported as a mean (SD) and is compared between groups via an independent t test, and the other continuous variables are reported as a median (IQR) and are compared between groups via a Mann-Whitney U test. A P value of <.05 was considered to be indicative of a statistically significant result and is reported in bold.

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Thien J. Huynh, Donna Parizadeh, Ahmed K. Ahmed, Christopher T. Gandia, Hal C. Davison, John V. Murray, Ian T. Mark, Ajay A. Madhavan, Darya Shlapak, Todd D. Rozen, Waleed Brinjikji, Prasanna Vibhute, Vivek Gupta, Kacie Brewer, Olga Fermo
Lateral Decubitus Dynamic CT Myelography with Real-Time Bolus Tracking (dCTM-BT) for Evaluation of CSF-Venous Fistulas: Diagnostic Yield Stratified by Brain Imaging Findings
American Journal of Neuroradiology Dec 2023, DOI: 10.3174/ajnr.A8082

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Lateral Decubitus Dynamic CT Myelography with Real-Time Bolus Tracking (dCTM-BT) for Evaluation of CSF-Venous Fistulas: Diagnostic Yield Stratified by Brain Imaging Findings
Thien J. Huynh, Donna Parizadeh, Ahmed K. Ahmed, Christopher T. Gandia, Hal C. Davison, John V. Murray, Ian T. Mark, Ajay A. Madhavan, Darya Shlapak, Todd D. Rozen, Waleed Brinjikji, Prasanna Vibhute, Vivek Gupta, Kacie Brewer, Olga Fermo
American Journal of Neuroradiology Dec 2023, DOI: 10.3174/ajnr.A8082
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