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Research ArticleHEAD AND NECK IMAGING

Diagnostic Value of Multiparameter MRI-Based Radiomics in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disorders

Ting Li, Xin Chen, Yang Jing, Haoru Wang, Ting Zhang, Li Zhang, Hao Ding, Mingye Xie and Ling He
American Journal of Neuroradiology November 2023, DOI: https://doi.org/10.3174/ajnr.A8045
Ting Li
aFrom the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., L.H.), Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China
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  • ORCID record for Ting Li
Xin Chen
aFrom the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., L.H.), Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China
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Yang Jing
bHuiying Medical Technology Co (Y.J.), Dongsheng Science and Technology Park, Beijing, China
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Haoru Wang
aFrom the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., L.H.), Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China
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  • ORCID record for Haoru Wang
Ting Zhang
aFrom the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., L.H.), Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China
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Li Zhang
aFrom the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., L.H.), Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China
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Hao Ding
aFrom the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., L.H.), Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China
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Mingye Xie
aFrom the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., L.H.), Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China
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Ling He
aFrom the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., L.H.), Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China
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  • Article
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Article Figures & Data

Figures

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    FIG 1.

    ROC curves of the clinical prediction model in the training and testing sets.

  • FIG 2.
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    FIG 2.

    ROC curves of the radiomics models. T1WI (A), T2WI (B), FLAIR (C), and the compound model (D) of 3 sequences.

Tables

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    Table 1:

    Clinical and MR imaging features of patients with and without MOGADa

    Patient CharacteristicMOGAD GroupNon-MOGAD GroupP Value
    Age (mean) (median) (yr)2.6 [SD, 3.1], 2.66.5 [SD, 3.7], 6.5.045
    Sex.217
     Male2727
     Female4126
    Cortex228.029
    White matter5445.437
    Thalamus4117.002
    Pedunculus cerebri237.009
    Cerebellar peduncles137.385
    Multifoci6648.129
    Involvement of both cerebral hemispheres5746.649
    • ↵a Significant difference with P value <.05.

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    Table 2:

    Univariate and multivariate logistic analysis in the cohort

    VariableUnivariate Analysis (P Value)Multivariate Analysis (P Value)
    Age.041a.017a
    Sex.753
    Cortex.027a.021a
    White matter.657
    Thalamus.220
    Pedunculus cerebri.072
    Cerebellar peduncles.172
    Multifoci.116
    Involvement of both cerebral hemispheres.749
    • aSignificant difference with P value <.05.

    • View popup
    Table 3:

    Evaluation indexes of T1WI, T2WI, FLAIR, and compound models in the training and testing sets

    ModelsAUC (95% CI)AccuracySensitivitySpecificity
    T1WI
     Training set0.781 (0.689–0.864)0.6900.7450.622
     Testing set0.500 (0.304–0.652)0.4590.5710.312
    T2WI
     Training set0.959 (0.924–0.987)0.8570.8940.811
     Testing set0.833 (0.697–0.944)0.7840.8570.688
    FLAIR
     Training set0.939 (0.898–0.979)0.8450.8510.838
     Testing set0.804 (0.664–0.918)0.7300.7620.688
    Compound
     Training set0.989 (0.976–0.999)0.9400.9360.946
     Testing set0.905 (0.803–0.979)0.8380.9050.750
    • View popup
    Table 4:

    DeLong test among T1WI, T2WI, FLAIR, and compound models in the training set

    ModelsDeLong Test (P value)
    T1WI training setT2WI training set0.0018
    FLAIR training set0.0041
    T2WI training setFLAIR training set0.3317
    Compound training set0.0502
    FLAIR training setCompound training set0.0061
    Compound training setT1WI training set<0.0001
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Diagnostic Value of Multiparameter MRI-Based Radiomics in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disorders
Ting Li, Xin Chen, Yang Jing, Haoru Wang, Ting Zhang, Li Zhang, Hao Ding, Mingye Xie, Ling He
American Journal of Neuroradiology Nov 2023, DOI: 10.3174/ajnr.A8045
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Ting Li, Xin Chen, Yang Jing, Haoru Wang, Ting Zhang, Li Zhang, Hao Ding, Mingye Xie, Ling He
Diagnostic Value of Multiparameter MRI-Based Radiomics in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disorders
American Journal of Neuroradiology Nov 2023, DOI: 10.3174/ajnr.A8045

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