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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging
Open Access

Exploratory Multisite Magnetic Resonance Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children

L.Y. Cai, C. Tanase, A.W. Anderson, N.J. Patel, C.A. Lee, R.S. Jones, L.M. LeStourgeon, A. Mahon, I. Taki, J. Juvera, S. Pruthi, K. Gwal, A. Ozturk, H. Kang, A. Rewers, M.J. Rewers, G.T. Alonso, N. Glaser, S. Ghetti, S.S. Jaser, B.A. Landman and L.C. Jordan
American Journal of Neuroradiology June 2023, DOI: https://doi.org/10.3174/ajnr.A7895
L.Y. Cai
aFrom the Department of Biomedical Engineering (L.Y.C., A.W.A., B.A.L.)
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  • ORCID record for L.Y. Cai
C. Tanase
dDepartments of Psychiatry and Behavioral Sciences (C.T.)
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A.W. Anderson
aFrom the Department of Biomedical Engineering (L.Y.C., A.W.A., B.A.L.)
bVanderbilt University Institute of Imaging Science (A.W.A., B.A.L.)
fDepartments of Radiology and Radiological Sciences (A.W.A., S.P., B.A.L.)
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N.J. Patel
gPediatrics (N.J.P., R.S.J., S.S.J., L.C.J.)
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C.A. Lee
hNeurology (C.A.L., L.C.J.)
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  • ORCID record for C.A. Lee
R.S. Jones
gPediatrics (N.J.P., R.S.J., S.S.J., L.C.J.)
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  • ORCID record for R.S. Jones
L.M. LeStourgeon
iMedicine (L.M.L.)
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A. Mahon
ePsychology (A.M., S.G.), University of California, Davis, Davis, California
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  • ORCID record for A. Mahon
I. Taki
kDepartment of Pediatrics (I.T., A.R., M.J.R.)
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J. Juvera
mDepartment of Psychiatry (J.J.), University of Colorado Anschutz Medical Campus, Aurora, Colorado
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  • ORCID record for J. Juvera
S. Pruthi
fDepartments of Radiology and Radiological Sciences (A.W.A., S.P., B.A.L.)
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K. Gwal
nDepartments of Radiology (K.G., A.O.)
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A. Ozturk
nDepartments of Radiology (K.G., A.O.)
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H. Kang
jBiostatistics (H.K.), Vanderbilt University Medical Center, Nashville, Tennessee
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A. Rewers
kDepartment of Pediatrics (I.T., A.R., M.J.R.)
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M.J. Rewers
kDepartment of Pediatrics (I.T., A.R., M.J.R.)
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G.T. Alonso
lBarbara Davis Center (G.T.A.)
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N. Glaser
oPediatrics (N.G.), University of California Davis Health, University of California Davis School of Medicine, Sacramento, California
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S. Ghetti
ePsychology (A.M., S.G.), University of California, Davis, Davis, California
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S.S. Jaser
gPediatrics (N.J.P., R.S.J., S.S.J., L.C.J.)
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B.A. Landman
aFrom the Department of Biomedical Engineering (L.Y.C., A.W.A., B.A.L.)
bVanderbilt University Institute of Imaging Science (A.W.A., B.A.L.)
cDepartment of Electrical and Computer Engineering (B.A.L.), Vanderbilt University, Nashville, Tennessee
fDepartments of Radiology and Radiological Sciences (A.W.A., S.P., B.A.L.)
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L.C. Jordan
gPediatrics (N.J.P., R.S.J., S.S.J., L.C.J.)
hNeurology (C.A.L., L.C.J.)
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A7895
PubMed 
37263786

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received February 18, 2023
  • Accepted after revision May 3, 2023
  • Published online June 1, 2023.

Article Versions

  • You are currently viewing a Latest version of this article (June 1, 2023 - 10:29).
  • latest version (June 29, 2023 - 08:01).
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Copyright & Usage 
© 2023 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. L.Y. Caia,
  2. C. Tanased,
  3. A.W. Andersona,b,f,
  4. N.J. Patelg,
  5. C.A. Leeh,
  6. R.S. Jonesg,
  7. L.M. LeStourgeoni,
  8. A. Mahone,
  9. I. Takik,
  10. J. Juveram,
  11. S. Pruthif,
  12. K. Gwaln,
  13. A. Ozturkn,
  14. H. Kangj,
  15. A. Rewersk,
  16. M.J. Rewersk,
  17. G.T. Alonsol,
  18. N. Glasero,
  19. S. Ghettie,
  20. S.S. Jaserg,
  21. B.A. Landmana,b,c,f and
  22. L.C. Jordang,h
  1. aFrom the Department of Biomedical Engineering (L.Y.C., A.W.A., B.A.L.)
  2. bVanderbilt University Institute of Imaging Science (A.W.A., B.A.L.)
  3. cDepartment of Electrical and Computer Engineering (B.A.L.), Vanderbilt University, Nashville, Tennessee
  4. dDepartments of Psychiatry and Behavioral Sciences (C.T.)
  5. ePsychology (A.M., S.G.), University of California, Davis, Davis, California
  6. fDepartments of Radiology and Radiological Sciences (A.W.A., S.P., B.A.L.)
  7. gPediatrics (N.J.P., R.S.J., S.S.J., L.C.J.)
  8. hNeurology (C.A.L., L.C.J.)
  9. iMedicine (L.M.L.)
  10. jBiostatistics (H.K.), Vanderbilt University Medical Center, Nashville, Tennessee
  11. kDepartment of Pediatrics (I.T., A.R., M.J.R.)
  12. lBarbara Davis Center (G.T.A.)
  13. mDepartment of Psychiatry (J.J.), University of Colorado Anschutz Medical Campus, Aurora, Colorado
  14. nDepartments of Radiology (K.G., A.O.)
  15. oPediatrics (N.G.), University of California Davis Health, University of California Davis School of Medicine, Sacramento, California
  1. Please address correspondence to Leon Y. Cai, Medical-Image Analysis and Statistical Interpretation Lab, 400 24th Ave S, FGH 369, Vanderbilt University, Nashville, TN 37212; e-mail: leon.y.cai{at}vanderbilt.edu; @LeonCai
View Full Text

Funding

  • National Science Foundation

    2040462
  • National Institutes of Health

    1U34DK123895-01; T32GM007347; U34DK123894-01

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  • Clinical and metabolic features of neurocognitive testing in children and adolescents with type 1 diabetes mellitus
    I.G. Samoilova, M.V. Matveeva, V.E. Yun, M.V. Koshmeleva, O.A. Oleinik, D.E. Galyukova, D.A. Kachanov, E.I. Trifonova, M.S. Gaun, E.L. Murzina
    Russian Journal of Preventive Medicine 2024 27 8
  • Gamma -aminobutyric acid ameliorates neurological impairments in type 1 diabetes mellitus mice by regulating the “gut flora-LPS-TLR4-NF-ΚB” signalling Axis
    Jiao Wang, Lihai Zhang, Xianhe Wang, Jing Dong, Jiaxin Li
    Diabetology & Metabolic Syndrome 2025 17 1
  • Intervention to reduce barriers to type 1 diabetes self-management: Diabetes Journey study design and participant characteristics
    Kimberly A. Driscoll, Paige J. Trojanowski, Desireé N. Williford, Holly K. O'Donnell, Erin Flynn, Constance A. Mara, Sara E. Wetter, Alexandra C. Himelhoch, Hannah Manis, Alicia Pardon, Cheyenne M. Reynolds, Emily R. Shaffer, Bailey Tanner, Jessica Kichler, Laura Smith, Sarah Westen, Anastasia Albanese-O'Neill, Sarah D. Corathers, Laura M. Jacobsen, Amy Poetker, Matthew Schmidt, Avani C. Modi
    Contemporary Clinical Trials 2025 152
  • Nuclear Magnetic Resonance
    M. J. W. Prior
    2024
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L.Y. Cai, C. Tanase, A.W. Anderson, N.J. Patel, C.A. Lee, R.S. Jones, L.M. LeStourgeon, A. Mahon, I. Taki, J. Juvera, S. Pruthi, K. Gwal, A. Ozturk, H. Kang, A. Rewers, M.J. Rewers, G.T. Alonso, N. Glaser, S. Ghetti, S.S. Jaser, B.A. Landman, L.C. Jordan
Exploratory Multisite Magnetic Resonance Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children
American Journal of Neuroradiology Jun 2023, DOI: 10.3174/ajnr.A7895

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Exploratory Multisite Magnetic Resonance Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children
L.Y. Cai, C. Tanase, A.W. Anderson, N.J. Patel, C.A. Lee, R.S. Jones, L.M. LeStourgeon, A. Mahon, I. Taki, J. Juvera, S. Pruthi, K. Gwal, A. Ozturk, H. Kang, A. Rewers, M.J. Rewers, G.T. Alonso, N. Glaser, S. Ghetti, S.S. Jaser, B.A. Landman, L.C. Jordan
American Journal of Neuroradiology Jun 2023, DOI: 10.3174/ajnr.A7895
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Clinical and metabolic features of neurocognitive testing in children and adolescents with type 1 diabetes mellitus
    I.G. Samoilova, M.V. Matveeva, V.E. Yun, M.V. Koshmeleva, O.A. Oleinik, D.E. Galyukova, D.A. Kachanov, E.I. Trifonova, M.S. Gaun, E.L. Murzina
    Russian Journal of Preventive Medicine 2024 27 8
  • Gamma -aminobutyric acid ameliorates neurological impairments in type 1 diabetes mellitus mice by regulating the “gut flora-LPS-TLR4-NF-ΚB” signalling Axis
    Jiao Wang, Lihai Zhang, Xianhe Wang, Jing Dong, Jiaxin Li
    Diabetology & Metabolic Syndrome 2025 17 1
  • Intervention to reduce barriers to type 1 diabetes self-management: Diabetes Journey study design and participant characteristics
    Kimberly A. Driscoll, Paige J. Trojanowski, Desireé N. Williford, Holly K. O'Donnell, Erin Flynn, Constance A. Mara, Sara E. Wetter, Alexandra C. Himelhoch, Hannah Manis, Alicia Pardon, Cheyenne M. Reynolds, Emily R. Shaffer, Bailey Tanner, Jessica Kichler, Laura Smith, Sarah Westen, Anastasia Albanese-O'Neill, Sarah D. Corathers, Laura M. Jacobsen, Amy Poetker, Matthew Schmidt, Avani C. Modi
    Contemporary Clinical Trials 2025 152
  • Nuclear Magnetic Resonance
    M. J. W. Prior
    2024

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