Article Figures & Data
Figures
- FIG 1.
STAT participant flow CONSORT diagram.20
- FIG 2.
Subgroup analysis of the primary outcome at 1 year. ACA indicates anterior cerebral artery.
Tables
Characteristics CA (n = 111) SAC (n = 94) Total (n = 205) Patient Age at treatment (mean) (SD) (yr) 58.6 (10.4) 58.0 (8.8) 58.3 (9.7) Female (No.) (%) 77 (69.4) 65 (69.1) 142 (69.3) STAT type lesion STAT-1: unruptured aneurysm, never treated, with a dimension of ≥ 10 mm (No.) (%) 21 (18.9) 17 (18.1) 38 (18.5) STAT-2: major recurrent aneurysm after previous coiling, but no previous stent placement (No.) (%) 41 (36.9) 34 (36.2) 75 (36.6) STAT-3: small (<10 mm), wide-neck (≥ 4 mm) aneurysm (No.) (%) 49 (44.1) 43 (45.7) 92 (44.9) Pretreatment mRS score (No.) (%) 0 84 (75.7) 70 (74.5) 154 (75.1) 1 21 (18.9) 20 (21.3) 41 (20.0) 2 5 (4.5) 2 (2.1) 7 (3.4) 3 1 (0.9) 1 (1.1) 2 (1.0) 4 0 1 (1.1) 1 (0.5) Presentation Symptomatic 4 (3.6) 4 (4.3) 8 (3.9) Additional aneurysm to a previously ruptured and treated one 13 (11.7) 6 (6.4) 19 (9.3) Incidental finding 94 (84.7) 84 (89.4) 178 (86.8) Index aneurysm location (No.) (%) Anterior circulation 78 (70.3) 58 (61.7) 136 (66.3) Ophthalmic/paraophthalmic 7 (6.3) 3 (3.2) 10 (4.9) Posterior communicating/anterior choroidal 7 (6.3) 13 (13.8) 20 (9.8) Carotid terminus 6 (5.4) 1 (1.1) 7 (3.4) MCA bifurcation/M1 18 (16.2) 14 (14.9) 32 (15.6) Anterior communicating/A1 40 (36.0) 25 (26.6) 65 (31.7) Distal ACA 0 2 (2.1) 2 (1.0) Posterior circulation 33 (29.7) 36 (38.3) 69 (33.7) PCA 0 3 (3.2) 3 (1.5) Basilar terminus 24 (21.6) 23 (24.5) 47 (22.9) SCA 3 (2.7) 5 (5.3) 8 (3.9) Basilar trunk 2 (1.8) 0 2 (1.0) Vertebrobasilar junction 2 (1.8) 2 (2.1) 4 (2.0) PICA 2 (1.8) 3 (3.2) 5 (2.4) Index aneurysm maximal external size (mean) (SD) (range) (mm) 9.2 (6.4) 9.2 (5.9) 9.2 (6.1) (2–50) (3–35) (2–50) <10 (No.) (%) 74 (66.7) 63 (67.0) 137 (66.8) ≥10 (No.) (%) 37 (33.3) 31 (33.0) 68 (33.2) Index aneurysm neck size (mean) (SD) (range) (mm) 4.4 (2.2) 4.1 (1.6) 4.3 (1.9) (2–20) (2–9) (2–20) Aneurysm neck ≥4 mm (No.) (%) 72 (64.9) 58 (61.7) 130 (63.4) Note:—ACA indicates anterior cerebral artery; PCA, posterior cerebral artery; SCA, superior cerebellar artery.
Intent-to-treat analysis 1-year outcomea CA
(n = 111)SAC
(n = 94)Treatment failure (composite) (No.) (%) 30 (27.3) 28 (30.1) Clinical mRS 6 2 (1.8) 3 (3.2) mRS 3–5 3 (2.7) 3 (3.2) Intracranial hemorrhage 0 0 Retreatment 0 3 (3.2) Angiographic Immediate failure 3 (2.7) 1 (1.1) Residual aneurysm (core lab) 22 (19.8) 18 (19.4) Missing primary outcome 1 (0.9) 1 (1.1) ↵a RR = 1.10; 95% CI, 0.71–1.71; P = .656.
CA (n = 111) SAC (n = 94) RR (95% CI) P Value Hospitalization 0.78 (0.48–1.28) .325 Patients hospitalized for >3 days (No.) (%) 30 (27.3) 20 (21.3) Discharge location (No.) (%) 1.18 (0.35–3.96) .788 Home 106 (95.5) 89 (94.7) Other than home 5 (4.5) 5 (5.3) Other hospital 1 (0.9) 0 Rehabilitation center 2 (1.8) 2 (2.1) Death 2 (1.8) 3 (3.2) mRS at discharge (No.) (%) 1.18 (0.35–3.96) .788 0 84 (75.7) 69 (73.4) 1 17 (15.3) 16 (17.0) 2 5 (4.5) 4 (4.3) 3 2 (1.8) 1 (1.1) 4 1 (0.9) 0 (0.0) 5 0 (0.0) 1 (1.1) 6 2 (1.8) 3 (3.2) 1 -Year mRS (No.) (%) 1.17 (0.43–3.22) .761 0 66 (60.0) 54 (57.4) 1 30 (27.3) 26 (27.7) 2 7 (6.4) 7 (7.4) 3 1 (0.9) 2 (2.1) 4 2 (1.8) 0 (0.0) 5 1 (0.9) 0 (0.0) 6 3 (2.7) 5 (5.3) Missing mRS data 1 (0.9) 0 Time of 1-year mRS assessment (mean) (SD) (mo) 15.7 (10.5) 15.3 (8.0) Morbidity and mortality at 1 year (mRS > 2), (No.) (%) 6 (5.4%) 8 (8.5%) Retreatment of index aneurysm during follow-up (No.) (%) 0 3 (3.2) Immediate angiographic outcome 0.97 (0.42–2.23) .936 Complete occlusion (No.) (%) 67 (60.4) 55 (58.5) Residual neck (No.) (%) 33 (29.7) 30 (31.9) Residual saccular aneurysm (No.) (%) 11 (9.9) 9 (9.6) Angiographic outcome at 1 year (core lab) (Detailed results in Online Supplemental Data) Complete occlusion (No.) (%) 38 (34.2) 42 (44.7) Residual neck (No.) (%) 43 (38.7) 24 (25.5) Residual saccular aneurysm (No.) (%) 27 (24.3) 24 (25.5) 1-year imaging not availablea (No.) (%) 3 (2.7) 4 (4.3) Time of 1-year imaging assessment (mean) (SD) (mo) 13.5 (5.2) 14.8 (9.5) Follow-up vascular imaginga (No.) (%) 108 (97.3) 90 (95.7) MRA (No.) (%) 82 (73.9) 53 (56.4) Catheter angiography (No.) (%) 24 (21.6) 35 (37.2) CTA (No.) (%) 2 (1.8) 2 (2.1) ↵a Three deaths in the CA group, 4 deaths in the SAC group. For 1 patient in the SAC group (who died 298 days after treatment), the 1-year imaging was adjudicated using the 3-month follow-up angiogram.
Intent to treat CA (n = 111) SAC (n = 94) Death (No.) (%) 3 (2.7) 5 (5.3%) Related 2 3 Unrelated 1 2 mRS 3–5 (No.) (%) 3 (2.7) 3 (3.2) Total (No.) (%) 6 (5.4) 8 (8.5) As-treated analysis 1-year outcomea CA
(n = 94)SAC
(n = 104)Treatment failure (composite) (No.) (%) 29 (30.9) 27 (26.0) Clinical mRS 6 1 (1.1) 4 (3.9) mRS 3–5 3 (3.2) 3 (3.1) Intracranial hemorrhage 0 0 Retreatment 0 3 (3.2) Angiographic Immediate failure 3 (3.3) 1 (1.1) Residual aneurysm (core lab) 22 (25.3) 16 (17.6) Missing primary outcome 0 2 (1.9) ↵a RR = 0.86; 95% CI, 0.55–1.34; P = .498.
As-treated CA (n = 94) SAC (n = 104) Death (No.) (%) 1 (1.1) 7 (6.7) Related 1 4 Unrelated 0 3 mRS 3–5 (No.) (%) 3 (3.2) 3 (2.9) Total (No.) (%) 4 (4.3) 10 (9.6)
