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Research ArticlePediatric Neuroimaging

Early Fetal Corpus Callosum: Demonstrating Normal Growth and Detecting Pathologies in Early Pregnancy

T. Weissbach, A. Massarwa, E. Hadi, S. Lev, A. Haimov, E. Katorza, A. Brenner-Weissmann, E. Krampl-Bettelheim, G. Kasprian, R. Sharon, R. Achiron, B. Weisz, Z. Kivilevitch and E. Kassif
American Journal of Neuroradiology January 2023, DOI: https://doi.org/10.3174/ajnr.A7757
T. Weissbach
aFrom The Institute of Obstetrical and Gynecological Imaging (T.W., A.M., E.H., E. Katorza, A.B.-W., R.A., B.W., E. Kassif)
dSackler School of Medicine (T.W., A.M., E.H., S.L., A.H., E. Katorza, A.B.-W., R.S., R.A., B.W., E. Kassif), Tel Aviv University, Tel Aviv, Israel
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A. Massarwa
aFrom The Institute of Obstetrical and Gynecological Imaging (T.W., A.M., E.H., E. Katorza, A.B.-W., R.A., B.W., E. Kassif)
dSackler School of Medicine (T.W., A.M., E.H., S.L., A.H., E. Katorza, A.B.-W., R.S., R.A., B.W., E. Kassif), Tel Aviv University, Tel Aviv, Israel
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E. Hadi
aFrom The Institute of Obstetrical and Gynecological Imaging (T.W., A.M., E.H., E. Katorza, A.B.-W., R.A., B.W., E. Kassif)
dSackler School of Medicine (T.W., A.M., E.H., S.L., A.H., E. Katorza, A.B.-W., R.S., R.A., B.W., E. Kassif), Tel Aviv University, Tel Aviv, Israel
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S. Lev
bDepartment of Obstetrics and Gynecology (S.L., A.H.)
dSackler School of Medicine (T.W., A.M., E.H., S.L., A.H., E. Katorza, A.B.-W., R.S., R.A., B.W., E. Kassif), Tel Aviv University, Tel Aviv, Israel
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A. Haimov
bDepartment of Obstetrics and Gynecology (S.L., A.H.)
dSackler School of Medicine (T.W., A.M., E.H., S.L., A.H., E. Katorza, A.B.-W., R.S., R.A., B.W., E. Kassif), Tel Aviv University, Tel Aviv, Israel
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E. Katorza
aFrom The Institute of Obstetrical and Gynecological Imaging (T.W., A.M., E.H., E. Katorza, A.B.-W., R.A., B.W., E. Kassif)
dSackler School of Medicine (T.W., A.M., E.H., S.L., A.H., E. Katorza, A.B.-W., R.S., R.A., B.W., E. Kassif), Tel Aviv University, Tel Aviv, Israel
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A. Brenner-Weissmann
aFrom The Institute of Obstetrical and Gynecological Imaging (T.W., A.M., E.H., E. Katorza, A.B.-W., R.A., B.W., E. Kassif)
dSackler School of Medicine (T.W., A.M., E.H., S.L., A.H., E. Katorza, A.B.-W., R.S., R.A., B.W., E. Kassif), Tel Aviv University, Tel Aviv, Israel
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E. Krampl-Bettelheim
eDepartment of Obstetrics and Gynecology (E.K.-B.)
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G. Kasprian
fDepartment of Biomedical Imaging and Image-Guided Therapy (G.K.), Medical University of Vienna, Vienna, Austria
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R. Sharon
cDepartment of Neurology (R.S.), Sheba Medical Center, Tel Hashomer, Israel
dSackler School of Medicine (T.W., A.M., E.H., S.L., A.H., E. Katorza, A.B.-W., R.S., R.A., B.W., E. Kassif), Tel Aviv University, Tel Aviv, Israel
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R. Achiron
aFrom The Institute of Obstetrical and Gynecological Imaging (T.W., A.M., E.H., E. Katorza, A.B.-W., R.A., B.W., E. Kassif)
dSackler School of Medicine (T.W., A.M., E.H., S.L., A.H., E. Katorza, A.B.-W., R.S., R.A., B.W., E. Kassif), Tel Aviv University, Tel Aviv, Israel
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B. Weisz
aFrom The Institute of Obstetrical and Gynecological Imaging (T.W., A.M., E.H., E. Katorza, A.B.-W., R.A., B.W., E. Kassif)
dSackler School of Medicine (T.W., A.M., E.H., S.L., A.H., E. Katorza, A.B.-W., R.S., R.A., B.W., E. Kassif), Tel Aviv University, Tel Aviv, Israel
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Z. Kivilevitch
gWomen’s Ultrasound Unit (Z.K.), Maccabi Health Services, Negev Medical Center, Beer-Sheva, Israel
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E. Kassif
aFrom The Institute of Obstetrical and Gynecological Imaging (T.W., A.M., E.H., E. Katorza, A.B.-W., R.A., B.W., E. Kassif)
dSackler School of Medicine (T.W., A.M., E.H., S.L., A.H., E. Katorza, A.B.-W., R.S., R.A., B.W., E. Kassif), Tel Aviv University, Tel Aviv, Israel
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  • FIG 1.
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    FIG 1.

    Imaging criteria for early CC identification. A, A hypoechogenic structure (double arrows) crossing the midline of the brain above the echogenic tela choroidea (single arrow), located beneath the pericallosal artery (black arrows, B).

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    FIG 2.

    The growing early CC between 13 and 18 weeks. Marked in each image are the tela choroidea (black arrowhead) and CC (white arrowheads). W indicates weeks.

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    FIG 3.

    Absent early CC. A, In the coronal plane of the third ventricle and thalami, structures crossing the midline are not apparent, resulting in an unroofed third ventricle (star). B, In the midsagittal plane, a prominent unroofed third ventricle (star) is observed in the designated location of the absent CC. C, Fetal MR imaging at 16 + 6 gestational weeks in the sagittal plane demonstrating the absence of the CC, resulting in an unroofed third ventricle (star) with the partial volume effect of the interthalamic adhesion and the anterior portion of the postcommissural fornix (white arrows). D, MR imaging in the coronal plane shows the unroofed third ventricle (black star) and the adjacent thalami (white stars).

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    FIG 4.

    A, Short and dysgenetic CC in Rubinstein-Taybi syndrome at 19.3 weeks. The rostrum is absent, the genu is underdeveloped (single arrow), and the splenium is short (double arrow), terminating prematurely at the anterior aspect (vertical line) of the massa intermedia (star). B, A normal CC at 19 weeks for comparison. The rostrum and genu (double arrow) are apparent and splenium (single arrow) is observed to extend beyond the posterior border (vertical line) of massa intermedia (star).

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    Table 1:

    Maternal characteristicsa

    Characteristicsn = 187
    Age (yr)32.3 (SD, 4.6)
    IVF16.5% (31/187)
    Prepregnancy weight (mean) (Kg)63.8 (SD, 12.6)
    Height (mean) (cm)163.15 (SD, 6.6)
    BMI (mean)24 (SD, 4.1)
    Gravidity (mean)2.5 (SD, 1.6)
    Parity1 (SD, 1.1)
    • Note:—IVF indicates in vitro fertilization; BMI, body mass index.

    • ↵a Data are presented as mean or percentage (n/N).

    • View popup
    Table 2:

    CC length—correlation with fetal characteristics

    Pearson Correlation Coefficient (r)P Value
    GA0.948<.001
    Head circumference0.964<.001
    Abdominal circumference0.948<.001
    Femur length0.377<.001
    Estimated fetal weight0.960<.001
    • View popup
    Table 3:

    Corpus callosum length (mm)a

    WeekNo.1st3rd5th10th25th50th75th90th95th97th99th
    13201.161.331.431.571.812.082.342.582.722.823.00
    14431.221.491.631.862.232.643.063.433.663.804.08
    15301.742.142.352.673.213.814.414.965.285.495.90
    16282.803.353.644.084.835.666.497.247.687.978.54
    17234.455.185.576.167.168.269.3610.3510.9511.3312.09
    18236.787.728.218.9810.2611.6913.1114.3915.1615.6516.63
    19209.8311.0211.6412.6114.2316.0217.8119.4320.4021.0222.25
    • ↵a Modeled are the first 99th centiles and reference range from the 13th to 19th week of gestation.

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T. Weissbach, A. Massarwa, E. Hadi, S. Lev, A. Haimov, E. Katorza, A. Brenner-Weissmann, E. Krampl-Bettelheim, G. Kasprian, R. Sharon, R. Achiron, B. Weisz, Z. Kivilevitch, E. Kassif
Early Fetal Corpus Callosum: Demonstrating Normal Growth and Detecting Pathologies in Early Pregnancy
American Journal of Neuroradiology Jan 2023, DOI: 10.3174/ajnr.A7757

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Early Fetal Corpus Callosum: Demonstrating Normal Growth and Detecting Pathologies in Early Pregnancy
T. Weissbach, A. Massarwa, E. Hadi, S. Lev, A. Haimov, E. Katorza, A. Brenner-Weissmann, E. Krampl-Bettelheim, G. Kasprian, R. Sharon, R. Achiron, B. Weisz, Z. Kivilevitch, E. Kassif
American Journal of Neuroradiology Jan 2023, DOI: 10.3174/ajnr.A7757
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