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Research ArticleNeurointervention

Treatment of Proximal Posterior Inferior Cerebellar Artery Aneurysms by Intrasaccular Flow Disruption: A Multicenter Experience

L. Goertz, T. Liebig, E. Siebert, Y. Özpeynirci, L. Pennig, E. Celik, M. Schlamann, F. Dorn and C. Kabbasch
American Journal of Neuroradiology July 2022, DOI: https://doi.org/10.3174/ajnr.A7566
L. Goertz
aFrom the Department of Radiology and Neuroradiology (L.G., L.P., E.C., M.S., C.K.), University of Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
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T. Liebig
bDepartment of Neuroradiology (T.L., Y.Ö.), University Hospital Munich, Munich, Germany
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E. Siebert
cDepartment of Neuroradiology (E.S.), University Hospital of Berlin (Charité), Berlin, Germany
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Y. Özpeynirci
bDepartment of Neuroradiology (T.L., Y.Ö.), University Hospital Munich, Munich, Germany
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L. Pennig
aFrom the Department of Radiology and Neuroradiology (L.G., L.P., E.C., M.S., C.K.), University of Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
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E. Celik
aFrom the Department of Radiology and Neuroradiology (L.G., L.P., E.C., M.S., C.K.), University of Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
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M. Schlamann
aFrom the Department of Radiology and Neuroradiology (L.G., L.P., E.C., M.S., C.K.), University of Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
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F. Dorn
dDepartment of Neuroradiology (F.D.), University Hospital Bonn, Bonn, Germany
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C. Kabbasch
aFrom the Department of Radiology and Neuroradiology (L.G., L.P., E.C., M.S., C.K.), University of Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
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  • FIG 1.
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    FIG 1.

    DSA shows a small, proximal PICA aneurysm (2 mm) in a patient with an SAH (A). Due to the broad neck of the aneurysm, the smallest available WEB in stock (SL, 3.5 × 2 mm) was deployed (B). However, the lower base of the WEB protruded markedly into the parent vessel (WEB contour highlighted by arrows). Implantation of an additional microstent seemed contraindicated because it might occlude the parent vessel (diameter, 1.3 mm) and would require permanent antiplatelet therapy. Hence, the WEB was removed before deployment, and the aneurysm was treated by implantation of a single coil (C). At final angiographic follow-up (21 months), the aneurysm was fully occluded and the PICA remained patent (D).

  • FIG 2.
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    FIG 2.

    DSA shows a ruptured proximal PICA aneurysm (3.2 mm; neck width, 3.0 mm; dome-to-neck ratio, 1.1 mm) (A and B). Due to the broad-based geometry and the ruptured aneurysm status, intrasaccular flow disruption was envisaged. After probing the aneurysm with a low-profile VIA 17 microcatheter (C), a WEB 17 SL (4 × 2 mm) was placed within the aneurysm sac, achieving immediate contrast stasis to prevent aneurysm rerupture (D). After neurointensive care treatment of the patient, the aneurysm showed persistent residual filling. Hence, an Acclino microstent was placed across the aneurysm neck from the PICA into the distal vertebral artery to optimize WEB positioning (E). At 3-month angiographic follow-up, the aneurysm was completely occluded. There was a moderate in-stent stenosis, which was asymptomatic (F).

  • FIG 3.
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    FIG 3.

    A 51-year-old female patient presented with a ruptured aneurysm at the proximal PICA (A and B). The aneurysm reruptured while the aneurysm sac was probed with the microcatheter. Extravasating contrast can be seen on the angiogram (C). However, directly after WEB deployment, the bleeding stopped due to intrasaccular stasis (D). Cerebellar infarction and herniation were excluded by a control CT (not shown). Although experiencing severe vasospasm, the patient survived and was transferred to a rehabilitation center with mild neurologic deficits (mRS 1). At 2 months, the WEB seemed to be fully thrombosed (E); however, the origin of the PICA, in particular the V4/PICA junction, appears to be dysplastic, warranting further angiographic control.

  • FIG 4.
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    FIG 4.

    DSA (A) and 3D reconstructions of rotational data sets (B) show an unruptured wide-neck aneurysm at the branching of the PICA from the vertebral artery. Due to its very broad-based geometry, treatment by conventional coiling is not feasible. To avoid crossing-over stent-assisted coiling, WEB embolization was envisaged. After we probed the aneurysm sac with a low-profile VIA 17 microcatheter (C), a WEB SL 3.5 × 2 cm was implanted (D), which sealed the aneurysm at its neck level and maintained full patency of the PICA. Immediate angiographic control after WEB implantation shows contrast stasis within the WEB (E). Six-month DSA shows complete aneurysm occlusion (RROC I) and patency of the PICA (F).

Tables

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    Table 1:

    Baseline patient and aneurysm characteristics

    CaseAge/SexUnruptured/Ruptured (WFNS)Size (mm)Neck Width (mm)D/N Ratio
    165/FUR3.42.71.3
    257/FR (I)3.23.01.1
    348/FUR2.92.61.1
    451/FR (IV)2.22.01.1
    564/FR (II)4.44.41.1
    678/FR (V)5.43.81.4
    771/FUR8.64.61.9
    863/FUR3.43.80.9
    956/FR (V)12.04.82.6
    1051/FUR3.02.41.3
    1170/FUR9.27.41.2
    1258/FR (V)2.01.71.2
    1352/FR (V)11.06.01.8
    1453/FUR3.42.31.5
    1563/FUR9.04.62.0
    1664/FUR4.62.71.7
    • Note:—F indicates female; UR, unruptured; R, ruptured; WFNS, World Federation of Neurosurgical Societies grading scale; D/N, dome-to-neck ratio.

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    Table 2:

    Procedural specifics

    CaseTreatmentComplicationsImmediate RROCRROC at
    FU (months)
    mRS at
    FU (months)
    1WEB SLS 4 mmApposition thrombus, tirofiban, no neurologic deficitII (6)0 (6)
    2WEB SL 4 × 2 mm + Acclino stent 3.5 × 20 mm (staged)III (3)0 (20)
    3WEB SL 3.5 × 2 mmII (6)0 (6)
    4WEB SL 3 × 2 mmAneurysm rerupture during WEB deployment, intrasaccular stasis, no deficitII (1)1 (1)
    5WEB SL 5 × 3 mmTransient hemianopsia partial posterior infarction, probably due to thromboembolismIII (7)1 (7)
    6WEB SL 6 × 4 mmIIIII (1)5 (1)
    7WEB DL 7 × 6 mm, 5 coilsIII (17)1 (17)
    8WEB SL 3 × 2 mmIIII (8)0 (8)
    9WEB SL 6 × 4 mm, 11 coilsIIII (10)2 (10)
    10WEB SL 3 × 2 mmIIII (5)0 (5)
    11WEB SL 9 × 4 mm, LEO Babya stent 4.5 × 25 mmWEB protrusion into the parent artery, adjunctive stent implantation, no ischemic complicationsIIIII (6)0 (6)
    12WEB SL 3.5 × 2 mm, coilingWEB implantation failed due to WEB protrusion, subsequent coil embolizationIII (21)0 (21)
    13WEB SL 11 × 6 mmIIII (1)6 (1)
    14WEB SL 4 × 3 mmIIII (1)0 (1)
    15WEB SL 9 × 4 mmIIIII (1)1 (1)
    16WEB SL 3.5 × 2 mmIII0 (6)
    • Note:—SLS indicates single-layer sphere; SL, single-layer; FU, follow-up; DL, dual-layer; RROC, Raymond-Roy occlusion classification.

    • ↵a Balt Extrusion.

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L. Goertz, T. Liebig, E. Siebert, Y. Özpeynirci, L. Pennig, E. Celik, M. Schlamann, F. Dorn, C. Kabbasch
Treatment of Proximal Posterior Inferior Cerebellar Artery Aneurysms by Intrasaccular Flow Disruption: A Multicenter Experience
American Journal of Neuroradiology Jul 2022, DOI: 10.3174/ajnr.A7566

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Treatment of Proximal Posterior Inferior Cerebellar Artery Aneurysms by Intrasaccular Flow Disruption: A Multicenter Experience
L. Goertz, T. Liebig, E. Siebert, Y. Özpeynirci, L. Pennig, E. Celik, M. Schlamann, F. Dorn, C. Kabbasch
American Journal of Neuroradiology Jul 2022, DOI: 10.3174/ajnr.A7566
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