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Research ArticlePediatric Neuroimaging
Open Access

ADC Histogram Analysis of Pediatric Low-Grade Glioma Treated with Selumetinib: A Report from the Pediatric Brain Tumor Consortium

S. Vajapeyam, D. Brown, A. Ziaei, S. Wu, G. Vezina, J.S. Stern, A. Panigrahy, Z. Patay, B. Tamrazi, J.Y. Jones, S.S. Haque, D.S. Enterline, S. Cha, B.V. Jones, K.W. Yeom, A. Onar-Thomas, I.J. Dunkel, M. Fouladi, J.R. Fangusaro and T.Y. Poussaint
American Journal of Neuroradiology February 2022, DOI: https://doi.org/10.3174/ajnr.A7433
S. Vajapeyam
aFrom the Department of Radiology (S.V., T.Y.P.), Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts
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  • ORCID record for S. Vajapeyam
D. Brown
bDepartment of Radiology (D.B.), Massachusetts General Hospital, Boston, Massachusetts
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A. Ziaei
cDepartment of Radiology (A.Z.), Boston Children’s Hospital, Boston, Massachusetts
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S. Wu
dDepartment of Biostatistics (S.W., A.O.-T.), St Jude Children’s Research Hospital, Memphis, Tennessee
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G. Vezina
eDepartment of Radiology (G.V.), Children’s National Medical Center, Washington, DC
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J.S. Stern
fDepartment of Radiology (J.S.S.), Ann and Robert H Lurie Children’s Hospital of Chicago, Chicago, Illinois
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A. Panigrahy
gDepartment of Radiology (A.P.), Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania
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Z. Patay
hDepartment of Diagnostic Imaging (Z.P.), St Jude Children’s Research Hospital, Memphis, Tennessee
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B. Tamrazi
iDepartment of Radiology (B.T.), Children’s Hospital Los Angeles, Los Angeles, California
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J.Y. Jones
jDepartment of Radiology (J.Y.J., M.F.), Nationwide Children’s Hospital, Columbus, Ohio
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S.S. Haque
kDepartment of Radiology (S.S.H., I.J.D.), Memorial Sloan Kettering Cancer Center, New York, New York
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D.S. Enterline
lDepartment of Radiology (D.S.E.), Duke University School of Medicine, Durham, North Carolina
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S. Cha
mDepartment of Radiology (S.C.), University of California San Francisco, San Francisco, California
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B.V. Jones
nDepartment of Radiology (B.V.J.), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
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K.W. Yeom
oDepartment of Radiology (K.W.Y.), Stanford University School of Medicine, Stanford, California
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A. Onar-Thomas
dDepartment of Biostatistics (S.W., A.O.-T.), St Jude Children’s Research Hospital, Memphis, Tennessee
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I.J. Dunkel
kDepartment of Radiology (S.S.H., I.J.D.), Memorial Sloan Kettering Cancer Center, New York, New York
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M. Fouladi
jDepartment of Radiology (J.Y.J., M.F.), Nationwide Children’s Hospital, Columbus, Ohio
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J.R. Fangusaro
pDepartment of Hematology, Oncology, and Stem Cell Transplantation (J.R.F.), Children’s Healthcare of Atlanta and Emory University, Atlanta, Georgia
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T.Y. Poussaint
aFrom the Department of Radiology (S.V., T.Y.P.), Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A7433
PubMed 
35210278

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received August 10, 2021
  • Accepted after revision January 1, 2022
  • Published online February 24, 2022.

Article Versions

  • You are currently viewing a Latest version of this article (February 24, 2022 - 10:08).
  • View the most recent version of this article
Copyright & Usage 
© 2022 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. S. Vajapeyama,
  2. D. Brownb,
  3. A. Ziaeic,
  4. S. Wud,
  5. G. Vezinae,
  6. J.S. Sternf,
  7. A. Panigrahyg,
  8. Z. Patayh,
  9. B. Tamrazii,
  10. J.Y. Jonesj,
  11. S.S. Haquek,
  12. D.S. Enterlinel,
  13. S. Cham,
  14. B.V. Jonesn,
  15. K.W. Yeomo,
  16. A. Onar-Thomasd,
  17. I.J. Dunkelk,
  18. M. Fouladij,
  19. J.R. Fangusarop and
  20. T.Y. Poussainta
  1. aFrom the Department of Radiology (S.V., T.Y.P.), Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts
  2. bDepartment of Radiology (D.B.), Massachusetts General Hospital, Boston, Massachusetts
  3. cDepartment of Radiology (A.Z.), Boston Children’s Hospital, Boston, Massachusetts
  4. dDepartment of Biostatistics (S.W., A.O.-T.), St Jude Children’s Research Hospital, Memphis, Tennessee
  5. eDepartment of Radiology (G.V.), Children’s National Medical Center, Washington, DC
  6. fDepartment of Radiology (J.S.S.), Ann and Robert H Lurie Children’s Hospital of Chicago, Chicago, Illinois
  7. gDepartment of Radiology (A.P.), Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania
  8. hDepartment of Diagnostic Imaging (Z.P.), St Jude Children’s Research Hospital, Memphis, Tennessee
  9. iDepartment of Radiology (B.T.), Children’s Hospital Los Angeles, Los Angeles, California
  10. jDepartment of Radiology (J.Y.J., M.F.), Nationwide Children’s Hospital, Columbus, Ohio
  11. kDepartment of Radiology (S.S.H., I.J.D.), Memorial Sloan Kettering Cancer Center, New York, New York
  12. lDepartment of Radiology (D.S.E.), Duke University School of Medicine, Durham, North Carolina
  13. mDepartment of Radiology (S.C.), University of California San Francisco, San Francisco, California
  14. nDepartment of Radiology (B.V.J.), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
  15. oDepartment of Radiology (K.W.Y.), Stanford University School of Medicine, Stanford, California
  16. pDepartment of Hematology, Oncology, and Stem Cell Transplantation (J.R.F.), Children’s Healthcare of Atlanta and Emory University, Atlanta, Georgia
  1. Please address correspondence to Sridhar Vajapeyam, MD, Children’s Hospital Boston, Radiology, 300 Longwood Ave, Boston, MA 02115; e-mail: sridhar.vajapeyam{at}childrens.harvard.edu
View Full Text

Funding

  • American Lebanese Syrian Associated Charities

  • AstraZeneca

  • National Cancer Institute

    NCI Cancer Therapy Evaluation Program; NIH/NCI Cancer Center Support Grant P30 CA008748; UM1CA081457

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S. Vajapeyam, D. Brown, A. Ziaei, S. Wu, G. Vezina, J.S. Stern, A. Panigrahy, Z. Patay, B. Tamrazi, J.Y. Jones, S.S. Haque, D.S. Enterline, S. Cha, B.V. Jones, K.W. Yeom, A. Onar-Thomas, I.J. Dunkel, M. Fouladi, J.R. Fangusaro, T.Y. Poussaint
ADC Histogram Analysis of Pediatric Low-Grade Glioma Treated with Selumetinib: A Report from the Pediatric Brain Tumor Consortium
American Journal of Neuroradiology Feb 2022, DOI: 10.3174/ajnr.A7433

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ADC Histogram Analysis of Pediatric Low-Grade Glioma Treated with Selumetinib: A Report from the Pediatric Brain Tumor Consortium
S. Vajapeyam, D. Brown, A. Ziaei, S. Wu, G. Vezina, J.S. Stern, A. Panigrahy, Z. Patay, B. Tamrazi, J.Y. Jones, S.S. Haque, D.S. Enterline, S. Cha, B.V. Jones, K.W. Yeom, A. Onar-Thomas, I.J. Dunkel, M. Fouladi, J.R. Fangusaro, T.Y. Poussaint
American Journal of Neuroradiology Feb 2022, DOI: 10.3174/ajnr.A7433
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • MRI histogram analysis of tumor-infiltrating CD8+ T cell levels in patients with glioblastoma
    Caiqiang Xue, Qing Zhou, Peng Zhang, Bin Zhang, Qiu Sun, Shenglin Li, Juan Deng, Xianwang Liu, Junlin Zhou
    NeuroImage: Clinical 2023 37
  • Whole-tumor histogram analysis of diffusion and perfusion metrics for noninvasive pediatric glioma grading
    Yan Su, Jie Kang, Xiang Lin, Dejun She, Wei Guo, Zhen Xing, Xiefeng Yang, Dairong Cao
    Neuroradiology 2023 65 6
  • Apparent diffusion coefficient histogram analysis to preoperative evaluate intracranial solitary fibrous tumor: Relationship to Ki-67 proliferation index
    Haiting Yang, Xianwang Liu, Jian Jiang, Junlin Zhou
    Clinical Neurology and Neurosurgery 2022 220

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