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Research ArticlePediatric Neuroimaging

ACTA2-Related Dysgyria: An Under-Recognized Malformation of Cortical Development

S. Subramanian, A. Biswas, C.A.P.F. Alves, S.V. Sudhakar, K.V. Shekdar, P. Krishnan, M. Shroff, A. Taranath, F. Arrigoni, K.A. Aldinger, R.J. Leventer, W.B. Dobyns and K. Mankad
American Journal of Neuroradiology December 2021, DOI: https://doi.org/10.3174/ajnr.A7364
S. Subramanian
aFrom the Division of Pediatric Radiology (S.S.), Department of Radiology, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania
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A. Biswas
bDepartment of Diagnostic Imaging (A.B., P.K., M.S.), The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
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C.A.P.F. Alves
cDivision of Neuroradiology (C.A.P.F.A.)
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S.V. Sudhakar
eDepartment of Radiology (S.V.S., K.M.), Great Ormond Street Hospital, NHS Foundation Trust, London, UK
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K.V. Shekdar
dDepartment of Radiology, and Department of Radiology (K.V.S.), Perelman School of Medicine at the University of Pennsylvania, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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P. Krishnan
bDepartment of Diagnostic Imaging (A.B., P.K., M.S.), The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
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M. Shroff
bDepartment of Diagnostic Imaging (A.B., P.K., M.S.), The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
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A. Taranath
fDepartment of Medical Imaging (A.T.), Women’s and Children’s Hospital, Adelaide, South Australia, Australia
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F. Arrigoni
gNeuroimaging Lab (F.A.), Scientific Institute, Istituto di Ricovero e Cura a Carattere Scientifico Eugenio Medea, Bosisio Parini, Italy
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K.A. Aldinger
hDepartment of Pediatrics (K.A.A.), University of Washington School of Medicine, Seattle, Washington
iCenter for Integrative Brain Research (K.A.A., W.B.D.), Seattle Children’s Research Institute, Seattle, Washington
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R.J. Leventer
jDepartment of Neurology (R.J.L.), Royal Children’s Hospital and Murdoch Children’s Research Institute, Parkville, Victoria, Australia
kDepartment of Pediatrics (R.J.L.), University of Melbourne, Melbourne, Victoria, Australia
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W.B. Dobyns
iCenter for Integrative Brain Research (K.A.A., W.B.D.), Seattle Children’s Research Institute, Seattle, Washington
lDivision of Genetics and Metabolism (W.B.D.), Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
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K. Mankad
eDepartment of Radiology (S.V.S., K.M.), Great Ormond Street Hospital, NHS Foundation Trust, London, UK
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A7364
PubMed 
34857515

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received August 11, 2021
  • Accepted after revision September 27, 2021
  • Published online December 2, 2021.

Article Versions

  • You are currently viewing a Latest version of this article (December 2, 2021 - 07:01).
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Copyright & Usage 
© 2022 by American Journal of Neuroradiology

Author Information

  1. S. Subramaniana,
  2. A. Biswasb,
  3. C.A.P.F. Alvesc,
  4. S.V. Sudhakare,
  5. K.V. Shekdard,
  6. P. Krishnanb,
  7. M. Shroffb,
  8. A. Taranathf,
  9. F. Arrigonig,
  10. K.A. Aldingerh,i,
  11. R.J. Leventerj,k,
  12. W.B. Dobynsi,l and
  13. K. Mankade
  1. aFrom the Division of Pediatric Radiology (S.S.), Department of Radiology, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania
  2. bDepartment of Diagnostic Imaging (A.B., P.K., M.S.), The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
  3. cDivision of Neuroradiology (C.A.P.F.A.)
  4. dDepartment of Radiology, and Department of Radiology (K.V.S.), Perelman School of Medicine at the University of Pennsylvania, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
  5. eDepartment of Radiology (S.V.S., K.M.), Great Ormond Street Hospital, NHS Foundation Trust, London, UK
  6. fDepartment of Medical Imaging (A.T.), Women’s and Children’s Hospital, Adelaide, South Australia, Australia
  7. gNeuroimaging Lab (F.A.), Scientific Institute, Istituto di Ricovero e Cura a Carattere Scientifico Eugenio Medea, Bosisio Parini, Italy
  8. hDepartment of Pediatrics (K.A.A.), University of Washington School of Medicine, Seattle, Washington
  9. iCenter for Integrative Brain Research (K.A.A., W.B.D.), Seattle Children’s Research Institute, Seattle, Washington
  10. jDepartment of Neurology (R.J.L.), Royal Children’s Hospital and Murdoch Children’s Research Institute, Parkville, Victoria, Australia
  11. kDepartment of Pediatrics (R.J.L.), University of Melbourne, Melbourne, Victoria, Australia
  12. lDivision of Genetics and Metabolism (W.B.D.), Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
  1. Please address correspondence to S. Subramanian, MD, UPMC Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pediatric Radiology, 4401 Penn Ave, Pittsburgh, PA 15224; e-mail: subramanian.subramanian2{at}chp.edu
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Cite this article
S. Subramanian, A. Biswas, C.A.P.F. Alves, S.V. Sudhakar, K.V. Shekdar, P. Krishnan, M. Shroff, A. Taranath, F. Arrigoni, K.A. Aldinger, R.J. Leventer, W.B. Dobyns, K. Mankad
ACTA2-Related Dysgyria: An Under-Recognized Malformation of Cortical Development
American Journal of Neuroradiology Dec 2021, DOI: 10.3174/ajnr.A7364

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ACTA2-Related Dysgyria: An Under-Recognized Malformation of Cortical Development
S. Subramanian, A. Biswas, C.A.P.F. Alves, S.V. Sudhakar, K.V. Shekdar, P. Krishnan, M. Shroff, A. Taranath, F. Arrigoni, K.A. Aldinger, R.J. Leventer, W.B. Dobyns, K. Mankad
American Journal of Neuroradiology Dec 2021, DOI: 10.3174/ajnr.A7364
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    American Journal of Roentgenology 2023 220 3
  • The Genetic Landscape of Ischemic Stroke in Children - Current Knowledge and Future Perspectives
    Moran Hausman-Kedem, Rachelle Herring, Marcela D Torres, Jonathan D. Santoro, Matsanga Leyila Kaseka, Carolina Vargas, Giulia Amico, Marta Bertamino, Deepti Nagesh, Jo Tilley, Allyson Schenk, Shay Ben-Shachar, Patricia L. Musolino
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