An Investigation of Water Diffusivity Changes along the Perivascular Space in Elderly Subjects with Hypertension

References

1. 1.↵
   1. Iliff JJ,
   2. Wang M,
   3. Liao Y, et al

   . A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 2012;4:147ra111 doi:10.1126/scitranslmed.3003748 pmid:22896675

   Abstract/FREE Full Text
2. 2.↵
   1. Jessen NA,
   2. Munk AS,
   3. Lundgaard I, et al

   . The glymphatic system: a beginner’s guide. Neurochem Res 2015;40:2583–99 doi:10.1007/s11064-015-1581-6 pmid:25947369

   CrossRefPubMed
3. 3.↵
   1. Iliff JJ,
   2. Lee H,
   3. Yu M, et al

   . Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 2013;123:1299–1309 doi:10.1172/JCI67677 pmid:23434588

   CrossRefPubMedWeb of Science
4. 4.↵
   1. Louveau A,
   2. Smirnov I,
   3. Keyes TJ, et al

   . Structural and functional features of central nervous system lymphatic vessels. Nature 2015;523:337–41 doi:10.1038/nature14432 pmid:26030524

   CrossRefPubMed
5. 5.↵
   1. Faraco G,
   2. Park L,
   3. Zhou P, et al

   . Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP. J Cereb Blood Flow Metab 2016;36:241–52 doi:10.1038/jcbfm.2015.79 pmid:25920959

   CrossRefPubMed
6. 6.↵
   1. Cifuentes D,
   2. Poittevin M,
   3. Dere E, et al

   . Hypertension accelerates the progression of Alzheimer-like pathology in a mouse model of the disease. Hypertension 2015;65:218–24 doi:10.1161/HYPERTENSIONAHA.114.04139 pmid:25331846

   CrossRefPubMed
7. 7.↵
   1. Tadic M,
   2. Cuspidi C,
   3. Hering D

   . Hypertension and cognitive dysfunction in elderly: blood pressure management for this global burden. BMC Cardiovasc Disord 2016;16:208 doi:10.1186/s12872-016-0386-0 pmid:27809779

   CrossRefPubMed
8. 8.↵
   1. Kress BT,
   2. Iliff JJ,
   3. Xia M, et al

   . Impairment of paravascular clearance pathways in the aging brain. Ann Neurol 2014;76:845–61 doi:10.1002/ana.24271 pmid:25204284

   CrossRefPubMed
9. 9.↵
   1. Plog BA,
   2. Dashnaw ML,
   3. Hitomi E, et al

   . Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system. J Neurosci 2015;35:518–26 doi:10.1523/JNEUROSCI.3742-14.2015 pmid:25589747

   Abstract/FREE Full Text
10. 10.↵
    1. Rasmussen MK,
    2. Mestre H,
    3. Nedergaard M

    . The glymphatic pathway in neurological disorders. Lancet Neurol 2018;17:1016–24 doi:10.1016/S1474-4422(18)30318-1 pmid:30353860

    CrossRefPubMed
11. 11.↵
    1. Rusanen M,
    2. Kivipelto M,
    3. Levälahti E, et al

    . Heart diseases and long-term risk of dementia and Alzheimer’s disease: a population-based CAIDE study. J Alzheimers Dis 2014;42:183–91 doi:10.3233/JAD-132363 pmid:24825565

    CrossRefPubMed
12. 12.↵
    1. Turana Y,
    2. Tengkawan J,
    3. Chia YC, et al

    . Hypertension and dementia: a comprehensive review from the HOPE Asia Network. J Clin Hypertens (Greenwich) 2019;21:1091–98 doi:10.1111/jch.13558 pmid:31131972

    CrossRefPubMed
13. 13.↵
    1. Mestre H,
    2. Tithof J,
    3. Du T, et al

    . Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nat Commun 2018;9:4878 doi:10.1038/s41467-018-07318-3 pmid:30451853

    CrossRefPubMed
14. 14.↵
    1. Mortensen KN,
    2. Sanggaard S,
    3. Mestre H, et al

    . Impaired glymphatic transport in spontaneously hypertensive rats. J Neurosci 2019;39:6365–77 doi:10.1523/JNEUROSCI.1974-18.2019 pmid:31209176

    Abstract/FREE Full Text
15. 15.↵
    1. Taoka T,
    2. Masutani Y,
    3. Kawai H, et al

    . Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases. Jpn J Radiol 2017;35:172–78 doi:10.1007/s11604-017-0617-z pmid:28197821

    CrossRefPubMed
16. 16.↵
    1. Someya Y,
    2. Tamura Y,
    3. Kaga H, et al

    . Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study. BMJ Open 2019;9:e031584 doi:10.1136/bmjopen-2019-031584 pmid:31530621

    Abstract/FREE Full Text
17. 17.↵
    1. Jenkinson M,
    2. Beckmann CF,
    3. Behrens TE, et al

    . FSL. Neuroimage 2012;62:782–90 doi:10.1016/j.neuroimage.2011.09.015 pmid:21979382

    CrossRefPubMedWeb of Science
18. 18.↵
    1. Yokota H,
    2. Vijayasarathi A,
    3. Cekic M, et al

    . Diagnostic performance of glymphatic system evaluation using diffusion tensor imaging in idiopathic normal pressure hydrocephalus and mimickers. Curr Gerontol Geriatr Res 2019;2019:1–10 doi:10.1155/2019/5675014 pmid:31320896

    CrossRefPubMed
19. 19.↵
    1. Aronow WS

    . Hypertension and cognitive impairment. Ann Transl Med 2017;5:259 doi:10.21037/atm.2017.03.99 pmid:28706927

    CrossRefPubMed
20. 20.↵
    1. Kario K,
    2. Pickering TG

    . Blood pressure variability in elderly patients. Lancet 2000;355:1645–46 doi:10.1016/S0140-6736(05)72549-6 pmid:10821389

    CrossRefPubMedWeb of Science
21. 21.↵
    1. Adler S,
    2. Martinez J,
    3. Williams DS, et al

    . Positive association between blood brain barrier disruption and osmotically-induced demyelination. Mult Scler 2000;6:24–31 doi:10.1177/135245850000600106 pmid:10694842

    CrossRefPubMedWeb of Science
22. 22.↵
    1. Yamamoto Y,
    2. Ihara M,
    3. Tham C, et al

    . Neuropathological correlates of temporal pole white matter hyperintensities in CADASIL. Stroke 2009;40:2004–11 doi:10.1161/STROKEAHA.108.528299 pmid:19359623

    Abstract/FREE Full Text
23. 23.↵
    1. Kamagata K,
    2. Andica C,
    3. Shimada K, et al

    . Effects of arterial stiffness on cerebral white matter integrity in the elderly. In: Proceedings of the Annual Meeting of the International Society for Magnetic Resonance in Medicine and the Society for MR Radiographers & Technologists, Virtual; August 8–14, 2020
24. 24.↵
    1. Joutel A,
    2. Corpechot C,
    3. Ducros A, et al

    . Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 1996;383:707–10 doi:10.1038/383707a0 pmid:8878478

    CrossRefPubMedWeb of Science
25. 25.↵
    1. Selwaness M,
    2. van den Bouwhuijsen Q,
    3. van Onkelen RS, et al

    . Atherosclerotic plaque in the left carotid artery is more vulnerable than in the right. Stroke 2014;45:3226–30 doi:10.1161/STROKEAHA.114.005202 pmid:25228259

    Abstract/FREE Full Text
26. 26.↵
    1. Martinac AD,
    2. Bilston LE

    . Computational modelling of fluid and solute transport in the brain. Biomech Model Mechanobiol 2020;19:781–800 doi:10.1007/s10237-019-01253-y pmid:31720888

    CrossRefPubMed
27. 27.↵
    1. Bewick V,
    2. Cheek L,
    3. Ball J

    . Statistics review 7: correlation and regression. Crit Care 2003;7:451–59 doi:10.1186/cc2401 pmid:14624685

    CrossRefPubMed
28. 28.↵
    1. Krzesinski JM

    . Management of high blood pressure in peripheral arterial disease. Acta Chir Belg 2005;105:560–66 doi:10.1080/00015458.2005.11679781 pmid:16438064

    CrossRefPubMed
29. 29.↵
    1. Iliff JJ,
    2. Wang M,
    3. Zeppenfeld DM, et al

    . Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. J Neurosci 2013;33:18190–99 doi:10.1523/JNEUROSCI.1592-13.2013 pmid:24227727

    Abstract/FREE Full Text
30. 30.↵
    1. Hadaczek P,
    2. Yamashita Y,
    3. Mirek H, et al

    . The “perivascular pump” driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol Ther 2006;14:69–78 doi:10.1016/j.ymthe.2006.02.018 pmid:16650807

    CrossRefPubMed
31. 31.↵
    1. Braun M,
    2. IIif J

    . The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseases. Int Rev Neurobiol 2020;154C:413–36 doi:10.1016/bs.irn.2020.02.006

    CrossRefPubMed
32. 32.↵
    1. Gaberel T,
    2. Gakuba C,
    3. Goulay R, et al

    . Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI. Stroke 2014;45:3092–96 doi:10.1161/STROKEAHA.114.006617 pmid:25190438

    Abstract/FREE Full Text
33. 33.↵
    1. Di Chiro G,
    2. Knop RH,
    3. Girton ME, et al

    . MR cisternography and myelography with Gd-DTPA in monkeys. Radiology 1985;157:373–77 doi:10.1148/radiology.157.2.4048444 pmid:4048444

    CrossRefPubMed
34. 34.↵
    1. Biceroglu H,
    2. Albayram S,
    3. Ogullar S, et al

    . Direct venous spinal reabsorption of cerebrospinal fluid: a new concept with serial magnetic resonance cisternography in rabbits. J Neurosurg Spine 2012;16:394–401 doi:10.3171/2011.12.SPINE11108 pmid:22243405

    CrossRefPubMed
35. 35.↵
    1. Naganawa S,
    2. Nakane T,
    3. Kawai H, et al

    . Gd-based contrast enhancement of the perivascular spaces in the basal ganglia. MRMS 2017;16:61–65 doi:10.2463/mrms.mp.2016-0039

    CrossRefPubMed
36. 36.↵
    1. Naganawa S,
    2. Nakane T,
    3. Kawai H, et al

    . Age dependence of gadolinium leakage from the cortical veins into the cerebrospinal fluid assessed with whole brain 3D-real inversion recovery MR imaging. Magn Reson Med Sci 2019;18:163–69 doi:10.2463/mrms.mp.2018-0053

    CrossRef
37. 37.↵
    1. Naganawa S,
    2. Nakane T,
    3. Kawai H, et al

    . Lack of contrast enhancement in a giant perivascular space of the basal ganglion on delayed flair images: implications for the glymphatic system. Magn Reson Med Sci 2017;16:89–90 doi:10.2463/mrms.ci.2016-0114 pmid:28123166

    CrossRefPubMed
38. 38.↵
    1. Siebner HR,
    2. von Einsiedel HG,
    3. Conrad B

    . Magnetic resonance ventriculography with gadolinium DTPA: report of two cases. Neuroradiology 1997;39:418–22 doi:10.1007/s002340050436 pmid:9225321

    CrossRefPubMed
39. 39.↵
    1. Ringstad G,
    2. Vatnehol SA,
    3. Eide PK

    . Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain 2017;140:2691–2705 doi:10.1093/brain/awx191 pmid:28969373

    CrossRefPubMed
40. 40.↵
    1. Kanda T,
    2. Ishii K,
    3. Kawaguchi H, et al

    . High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology 2014;270:834–41 doi:10.1148/radiol.13131669

    CrossRefPubMed
41. 41.↵
    1. Taoka T,
    2. Naganawa S

    . Gadolinium-based contrast media, cerebrospinal fluid and the glymphatic system: possible mechanisms for the deposition of gadolinium in the brain. Magn Reson Med Sci 2018;17:111–19 doi:10.2463/mrms.rev.2017-0116 pmid:29367513

    CrossRefPubMed
42. 42.↵
    1. Samardzic D,
    2. Thamburaj K

    . Magnetic resonance characteristics and susceptibility weighted imaging of the brain in gadolinium encephalopathy. J Neuroimaging 2015;25:136–39 doi:10.1111/jon.12067 pmid:24251880

    CrossRefPubMed
43. 43.↵
    1. Arlt S,
    2. Cepek L,
    3. Rustenbeck HH, et al

    . Gadolinium encephalopathy due to accidental intrathecal administration of gadopentetate dimeglumine. J Neurol 2007;254:810–12 doi:10.1007/s00415-006-0439-x pmid:17401744

    CrossRefPubMed
44. 44.↵
    1. Provenzano DA,
    2. Pellis Z,
    3. DeRiggi L

    . Fatal gadolinium-induced encephalopathy following accidental intrathecal administration: a case report and a comprehensive evidence-based review. Reg Anesth Pain Med 2019;44:721–79 doi:10.1136/rapm-2019-100422

    Abstract/FREE Full Text
45. 45.↵
    1. Smith AJ,
    2. Yao X,
    3. Dix JA, et al

    . Test of the ‘glymphatic’ hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma. eLife 2017;6:e677679 doi:10.7554/eLife.27679 pmid:28826498

    CrossRefPubMed
46. 46.↵
    1. Asgari M,
    2. de Zélicourt D,
    3. Kurtcuoglu V

    . Glymphatic solute transport does not require bulk flow. Sci Rep 2016;6:38635 doi:10.1038/srep38635 pmid:27929105

    CrossRefPubMed
47. 47.↵
    1. Koundal S,
    2. Elkin R,
    3. Nadeem S, et al

    . Optimal mass transport with Lagrangian workflow reveals advective and diffusion driven solute transport in the glymphatic system. Sci Rep 2020;10:1990 doi:10.1038/s41598-020-59045-9 pmid:32029859

    CrossRefPubMed
48. 48.↵
    1. Steward CE,
    2. Venkatraman VK,
    3. Lui E, et al

    . Assessment of the DTI-ALPS parameter along the perivascular space in older adults at risk of dementia. J Neuroimaging 2021;31:569–78 doi:10.1111/jon.12837 pmid:33556226

    CrossRefPubMed
49. 49.↵
    1. Yang G,
    2. Deng N,
    3. Liu Y, et al

    . Evaluation of glymphatic system using diffusion MR technique in T2DM cases. Front Hum Neurosci 2020;14:300 doi:10.3389/fnhum.2020.00300 pmid:32922272

    CrossRefPubMed
50. 50.↵
    1. Chen HL,
    2. Chen PC,
    3. Lu CH, et al

    . Associations among cognitive functions, plasma DNA, and diffusion tensor image along the perivascular space (DTI-ALPS) in patients with Parkinson’s disease. Oxid Med Cell Longev 2021;2021:4034509 doi:10.1155/2021/4034509 pmid:33680283

    CrossRefPubMed
51. 51.↵
    1. Jiang Q,
    2. Zhang L,
    3. Ding G, et al

    . Impairment of the glymphatic system after diabetes. J Cereb Blood Flow Metab 2017;37:1326–37 doi:10.1177/0271678X16654702 pmid:27306755

    CrossRefPubMed
52. 52.↵
    1. Zhang W,
    2. Zhou Y,
    3. Wang J, et al

    . Glymphatic clearance function in patients with cerebral small vessel disease. Neuroimage 2021;238:118257 doi:10.1016/j.neuroimage.2021.118257 pmid:34118396

    CrossRefPubMed