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Research ArticlePediatric Neuroimaging
Open Access

Anatomic Neuroimaging Characteristics of Posterior Fossa Type A Ependymoma Subgroups

N.D. Sabin, S.N. Hwang, P. Klimo, N. Chambwe, R.G. Tatevossian, T. Patni, Y. Li, F.A. Boop, E. Anderson, A. Gajjar, T.E. Merchant and D.W. Ellison
American Journal of Neuroradiology October 2021, DOI: https://doi.org/10.3174/ajnr.A7322
N.D. Sabin
aFrom the Departments of Diagnostic Imaging (N.D.S., S.N.H., E.A.)
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S.N. Hwang
aFrom the Departments of Diagnostic Imaging (N.D.S., S.N.H., E.A.)
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P. Klimo Jr
fSurgery (P.K., F.A.B.,), St. Jude Children’s Research Hospital, Memphis, Tennessee
gSemmes Murphey (P.K., F.A.B.), Memphis, Tennessee.
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N. Chambwe
bPathology (N.C., R.G.T., D.W.E.)
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R.G. Tatevossian
bPathology (N.C., R.G.T., D.W.E.)
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T. Patni
dBiostatistics (T.P., Y.L.)
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Y. Li
dBiostatistics (T.P., Y.L.)
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F.A. Boop
fSurgery (P.K., F.A.B.,), St. Jude Children’s Research Hospital, Memphis, Tennessee
gSemmes Murphey (P.K., F.A.B.), Memphis, Tennessee.
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E. Anderson
aFrom the Departments of Diagnostic Imaging (N.D.S., S.N.H., E.A.)
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A. Gajjar
cOncology (A.G.)
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T.E. Merchant
eRadiation Oncology (T.E.M.)
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D.W. Ellison
bPathology (N.C., R.G.T., D.W.E.)
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  • FIG 1.
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    FIG 1.

    PFA ependymoma types based on location. Sagittal T1- (A) and axial T2-weighted images (B): Midfloor-type posterior fossa ependymomas fill the obex (arrowhead), and a gap may be seen between the roof of the fourth ventricle and the tumor (arrows, A). The brainstem is displaced anteriorly (arrow, B), and in the sagittal plane, it is seen in its entirety in a single sagittal image. Sagittal T1- (C) and axial T2-weighted images (D): Lateral-type posterior fossa ependymomas are centered in the lateral recess of the fourth ventricle or cerebellopontine angle (arrows, C) and displace the brainstem laterally (arrow, D). The brainstem usually cannot be seen in a single sagittal image. Postgadolinium sagittal T1- (E) and axial T2-weighted images (F): Roof-type posterior fossa ependymomas appear closely associated with the roof of the fourth ventricle (arrows, E and F) and do not fill the obex (arrowhead, E). A gap is usually seen between the tumor and the floor of the fourth ventricle (arrowhead, F).

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    FIG 2.

    PFA-2c ependymoma versus another subtype. Postgadolinium sagittal T1- (A) and axial T2-weighted (C) MR images of a PFA-2c subtype ependymoma and sagittal T1- (B) and axial T2-weighted (D) MR images of another PFA ependymoma subtype (1b) show that the PFA-2c ependymoma has a more circumscribed appearance in that it does not wrap around the brainstem or extend below the foramen magnum in distinction from the PFA-1b subtype (arrow, B). The PFA-2c ependymoma in this case did not extend through the foramina of Luschka, unlike the PFA-1b tumor (arrows, D), or encase the basilar or vertebral arteries. This more circumscribed appearance was seen in the 5 PFA-2c tumors in our study, though evaluation of a larger number of this subtype is needed to confirm this appearance as a characteristic of PFA-2c ependymomas.

Tables

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    Table 1:

    Association of imaging variables with PFA ependymoma subgroups

    Yes (%)No (%)
    Extends below foramen magnum, P = .18
     PFA-167 (89.3)8 (10.7)
     PFA-237 (78.7)10 (21.3)
     Total104 (85.2)18 (14.8)
    Involves foramina of Luschka, P = .55
     PFA-161 (81.3)14 (18.7)
     PFA-241 (87.2)6 (12.8)
     Total102 (83.6)20 (16.4)
    Encases blood vessels, P = .73
     PFA-133 (44.0)42 (56.0)
     PFA-223 (48.9)24 (51.1)
     Total56 (45.9)66 (54.1)
    Necrosis (P = .03)a
     PFA-159 (80.8)14 (19.2)
     PFA-228 (60.9)18 (39.1)
     Total87 (73.1)32 (26.9)
    Hydrocephalus, P = .36
     PFA-165 (86.7)10 (13.3)
     PFA-244 (93.6)3 (6.4)
     Total109 (89.3)13 (10.7)
    • ↵a Data for this variable were available for 119 subjects because 3 patients did not have preoperative postcontrast images available.

    • View popup
    Table 2:

    Anatomic type on imaging (P = .24)

    Lateral (%)Midfloor (%)Roof (%)
    PFA-133 (44.0)32 (42.7)10 (13.3)
    PFA-214 (29.8)23 (48.9)10 (21.3)
    Total47 (38.5)55 (45.1)20 (16.4)
    • View popup
    Table 3:

    Imaging characteristics of PFA-2c ependymomas compared with other PFA-2 subtypes and all other PFA subtypesa

    YesNo
    Extends below foramen magnum
     PFA-2c0 (0%)5 (100%)
     PFA-2a and PFA-2b29 (87.9%)4 (12.1%)
     All other PFA tumors96 (88.9%)12 (11.1%)
    Encases blood vessels
     PFA-2c0 (0%)5 (100%)
     PFA-2a and PFA-2b17 (51.5%)16 (48.5%)
     All other PFA tumors50 (46.3%)58 (53.7%)
    Involves foramina of Luschka
     PFA-2c2 (40%)3 (60%)
     PFA-2a and PFA-2b31 (93.9%)2 (6.1%)
     All other PFA tumors92 (85.2%)16 (14.8%)
    • ↵a Ninety-eight subjects had subtype data available. “All other PFA tumors” includes the PFA-1 subgroup and the PFA-2a and 2b subtypes. The 15 subjects with PFA-1 subgroup ependymomas that could not be subtyped were included in the category of All other PFA tumors. The 8 patients with PFA-2 tumors that could not be subtyped were not included in this analysis.

    • View popup
    Table 4:

    Imaging type of PFA-2c ependymomas compared with other PFA-2 subtypes and all other PFA subtypesa

    LateralMidfloorRoof
    PFA-2c0 (0%)5 (100%)0 (0%)
    PFA-2a and PFA-2b10 (30.3%)14 (42.4%)9 (27.3%)
    All other PFA tumors43 (39.8%)46 (42.6%)19 (17.6%)
    • ↵a Ninety-eight subjects had subtype data available. “All other PFA tumors” includes the PFA-1 subgroup and the PFA-2a and 2b subtypes. The 15 subjects with PFA-1 subgroup ependymomas that could not be subtyped were included in the category of All other PFA tumors. The 8 patients with PFA-2 tumors that could not be subtyped were not included in this analysis.

    • View popup
    Table 5:

    PFA-2c ependymomas compared with other PFA-2 ependymoma subtypes and all other PFA subtypes with respect to flag variable 1a

    Flag Variable 1bYesNo
    PFA-2c5 (100%)0 (0%)
    PFA-2a and PFA-2b3 (9%)30 (91%)
    All other PFA tumors6 (5.6%)102 (94.4%)
    • ↵a Ninety-eight subjects had subtype data available. “All other PFA tumors” includes the PFA-1 subgroup and the PFA-2a and 2b subtypes. The 15 subjects with PFA-1 subgroup ependymomas that could not be subtyped were included in the category of All other PFA tumors. The 9 patients with PFA-2 tumors that could not be subtyped were not included in this analysis.

    • ↵b The flag variable incorporates the following 3 variables: “no” for extension below the foramen magnum, “no” for encases blood vessels, and “midfloor-type” tumor.

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Cite this article
N.D. Sabin, S.N. Hwang, P. Klimo, N. Chambwe, R.G. Tatevossian, T. Patni, Y. Li, F.A. Boop, E. Anderson, A. Gajjar, T.E. Merchant, D.W. Ellison
Anatomic Neuroimaging Characteristics of Posterior Fossa Type A Ependymoma Subgroups
American Journal of Neuroradiology Oct 2021, DOI: 10.3174/ajnr.A7322

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Anatomic Neuroimaging Characteristics of Posterior Fossa Type A Ependymoma Subgroups
N.D. Sabin, S.N. Hwang, P. Klimo, N. Chambwe, R.G. Tatevossian, T. Patni, Y. Li, F.A. Boop, E. Anderson, A. Gajjar, T.E. Merchant, D.W. Ellison
American Journal of Neuroradiology Oct 2021, DOI: 10.3174/ajnr.A7322
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