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Research ArticleAdult Brain
Open Access

Strength of Association between Infarct Volume and Clinical Outcome Depends on the Magnitude of Infarct Size: Results from the ESCAPE-NA1 Trial

J.M. Ospel, M.D. Hill, B.K. Menon, A. Demchuk, R. McTaggart, R. Nogueira, A. Poppe, D. Haussen, W. Qiu, A. Mayank, M. Almekhlafi, C. Zerna, M. Joshi, M. Jayaraman, D. Roy, J. Rempel, B. Buck, M. Tymianski, M. Goyal and for the ESCAPE-NA1 investigators
American Journal of Neuroradiology June 2021, DOI: https://doi.org/10.3174/ajnr.A7183
J.M. Ospel
aDepartment of Clinical Neurosciences (J.M.O., M.D.H., B.K.M., A.D., W.Q., A.M., M.A., C.Z., M.G.), University of Calgary, Calgary, Alberta, Canada
cDepartment of Radiology (J.M.O.), University Hospital of Basel, Basel, Switzerland
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  • ORCID record for J.M. Ospel
M.D. Hill
aDepartment of Clinical Neurosciences (J.M.O., M.D.H., B.K.M., A.D., W.Q., A.M., M.A., C.Z., M.G.), University of Calgary, Calgary, Alberta, Canada
bDepartment of Radiology (M.D.H., B.K.M., A.D., M.A., M. Joshi, M.G.), University of Calgary, Calgary, Alberta, Canada
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B.K. Menon
aDepartment of Clinical Neurosciences (J.M.O., M.D.H., B.K.M., A.D., W.Q., A.M., M.A., C.Z., M.G.), University of Calgary, Calgary, Alberta, Canada
bDepartment of Radiology (M.D.H., B.K.M., A.D., M.A., M. Joshi, M.G.), University of Calgary, Calgary, Alberta, Canada
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A. Demchuk
aDepartment of Clinical Neurosciences (J.M.O., M.D.H., B.K.M., A.D., W.Q., A.M., M.A., C.Z., M.G.), University of Calgary, Calgary, Alberta, Canada
bDepartment of Radiology (M.D.H., B.K.M., A.D., M.A., M. Joshi, M.G.), University of Calgary, Calgary, Alberta, Canada
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  • ORCID record for A. Demchuk
R. McTaggart
dDepartment of Interventional Radiology (R.M., M. Jayaraman), Warren Alpert Medical School of Brown University, Providence, Rhode Island
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R. Nogueira
eDepartment of Neurology (R.N., D.H.), Emory University School of Medicine, Atlanta, Georgia
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A. Poppe
fCentre Hospitalier de l’Université de Montréal (A.P., D.R.), Montreal, Quebec, Canada
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D. Haussen
eDepartment of Neurology (R.N., D.H.), Emory University School of Medicine, Atlanta, Georgia
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W. Qiu
aDepartment of Clinical Neurosciences (J.M.O., M.D.H., B.K.M., A.D., W.Q., A.M., M.A., C.Z., M.G.), University of Calgary, Calgary, Alberta, Canada
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A. Mayank
aDepartment of Clinical Neurosciences (J.M.O., M.D.H., B.K.M., A.D., W.Q., A.M., M.A., C.Z., M.G.), University of Calgary, Calgary, Alberta, Canada
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M. Almekhlafi
aDepartment of Clinical Neurosciences (J.M.O., M.D.H., B.K.M., A.D., W.Q., A.M., M.A., C.Z., M.G.), University of Calgary, Calgary, Alberta, Canada
bDepartment of Radiology (M.D.H., B.K.M., A.D., M.A., M. Joshi, M.G.), University of Calgary, Calgary, Alberta, Canada
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C. Zerna
aDepartment of Clinical Neurosciences (J.M.O., M.D.H., B.K.M., A.D., W.Q., A.M., M.A., C.Z., M.G.), University of Calgary, Calgary, Alberta, Canada
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M. Joshi
bDepartment of Radiology (M.D.H., B.K.M., A.D., M.A., M. Joshi, M.G.), University of Calgary, Calgary, Alberta, Canada
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M. Jayaraman
dDepartment of Interventional Radiology (R.M., M. Jayaraman), Warren Alpert Medical School of Brown University, Providence, Rhode Island
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D. Roy
fCentre Hospitalier de l’Université de Montréal (A.P., D.R.), Montreal, Quebec, Canada
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J. Rempel
gUniversity of Alberta Hospital ( J.R., B.B.), Edmonton, Alberta, Canada
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B. Buck
gUniversity of Alberta Hospital ( J.R., B.B.), Edmonton, Alberta, Canada
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M. Tymianski
hNoNO Inc (M.T.), Toronto, Ontario, Canada
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M. Goyal
aDepartment of Clinical Neurosciences (J.M.O., M.D.H., B.K.M., A.D., W.Q., A.M., M.A., C.Z., M.G.), University of Calgary, Calgary, Alberta, Canada
bDepartment of Radiology (M.D.H., B.K.M., A.D., M.A., M. Joshi, M.G.), University of Calgary, Calgary, Alberta, Canada
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A7183
PubMed 
34167959

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received December 30, 2020
  • Accepted after revision March 17, 2021
  • Published online June 24, 2021.

Article Versions

  • You are currently viewing a Latest version of this article (June 24, 2021 - 06:43).
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Copyright & Usage 
© 2021 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. J.M. Ospela,c,
  2. M.D. Hilla,b,
  3. B.K. Menona,b,
  4. A. Demchuka,b,
  5. R. McTaggartd,
  6. R. Nogueirae,
  7. A. Poppef,
  8. D. Haussene,
  9. W. Qiua,
  10. A. Mayanka,
  11. M. Almekhlafia,b,
  12. C. Zernaa,
  13. M. Joshib,
  14. M. Jayaramand,
  15. D. Royf,
  16. J. Rempelg,
  17. B. Buckg,
  18. M. Tymianskih,
  19. M. Goyala,b,
  20. for the ESCAPE-NA1 investigators
  1. aDepartment of Clinical Neurosciences (J.M.O., M.D.H., B.K.M., A.D., W.Q., A.M., M.A., C.Z., M.G.), University of Calgary, Calgary, Alberta, Canada
  2. bDepartment of Radiology (M.D.H., B.K.M., A.D., M.A., M. Joshi, M.G.), University of Calgary, Calgary, Alberta, Canada
  3. cDepartment of Radiology (J.M.O.), University Hospital of Basel, Basel, Switzerland
  4. dDepartment of Interventional Radiology (R.M., M. Jayaraman), Warren Alpert Medical School of Brown University, Providence, Rhode Island
  5. eDepartment of Neurology (R.N., D.H.), Emory University School of Medicine, Atlanta, Georgia
  6. fCentre Hospitalier de l’Université de Montréal (A.P., D.R.), Montreal, Quebec, Canada
  7. gUniversity of Alberta Hospital ( J.R., B.B.), Edmonton, Alberta, Canada
  8. hNoNO Inc (M.T.), Toronto, Ontario, Canada
  1. Please address correspondence to Mayank Goyal, MD, PhD, Departments of Clinical Neurosciences and Diagnostic Imaging, University of Calgary, 1079 A, 29th St NW, Calgary, AB, Canada, T2N 2T9; e-mail: mgoyal{at}ucalgary.ca; @johanna_ospel; @mayank_G0
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Funding

  • Canadian Institutes for Health Research, Alberta Innovates, and NoNO Inc.

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J.M. Ospel, M.D. Hill, B.K. Menon, A. Demchuk, R. McTaggart, R. Nogueira, A. Poppe, D. Haussen, W. Qiu, A. Mayank, M. Almekhlafi, C. Zerna, M. Joshi, M. Jayaraman, D. Roy, J. Rempel, B. Buck, M. Tymianski, M. Goyal, for the ESCAPE-NA1 investigators
Strength of Association between Infarct Volume and Clinical Outcome Depends on the Magnitude of Infarct Size: Results from the ESCAPE-NA1 Trial
American Journal of Neuroradiology Jun 2021, DOI: 10.3174/ajnr.A7183

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Strength of Association between Infarct Volume and Clinical Outcome Depends on the Magnitude of Infarct Size: Results from the ESCAPE-NA1 Trial
J.M. Ospel, M.D. Hill, B.K. Menon, A. Demchuk, R. McTaggart, R. Nogueira, A. Poppe, D. Haussen, W. Qiu, A. Mayank, M. Almekhlafi, C. Zerna, M. Joshi, M. Jayaraman, D. Roy, J. Rempel, B. Buck, M. Tymianski, M. Goyal, for the ESCAPE-NA1 investigators
American Journal of Neuroradiology Jun 2021, DOI: 10.3174/ajnr.A7183
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