Article Figures & Data
Figures
- FIG 1.
Flow chart detailing patient selection (A) along with a histogram detailing how many subjects had a specific number of scans performed (B).
- FIG 2.
Plot of the percentage change from the first to last scan of the signal intensity ratios of both DN/P and GP/T. Circles represent each of the 131 individual subjects. Error bars indicate the SD from the mean.
- FIG 3.
Scatterplot of the lowest and average eGFR versus percentage change in signal intensity ratios of GP/T, shown in A and C, respectively, and DN/P, shown in B and D, respectively, from first to last scan. Lines of best fit are also shown on each graph.
- FIG 4.
Plot of the lowest and average eGFR versus percentage change in signal intensity ratios of GP/T, shown in A and C, respectively, and DN/P, shown in B and D, respectively, from first to last scan, broken down by eGFR groupings. eGFR batches were >90, 60–90, 45–60, <45 for the lowest eGFR, and >90, 60–90, <60 for the average eGFR. Circles represent each of the 131 individual subjects. Error bars indicate the SD from the mean.
Tables
Parameter Result (Total n = 131) Age at last scan (mean) (range) (yr) 55.95 (3–86) Sex Male (No.) 58 Female (No.) 73 Indication for imaging Current or prior tumor (No.) 127 Cerebral amyloid angiopathy (No.) 1 Neurosarcoidosis (No.) 1 Progressive multifocal leukoencephalopathy (No.) 1 Recurrent abscesses (No.) 1 Total gadobutrol dose (mean) [SD] (mL) 85.43 [29.20] No. of scans (mean) (range) 12.31 (10–28) Time between first and last scan (median) (range) (mo) 32.4 (2.1–47.2) Lowest eGFR (mL/min/m2) >90 (No.) (range) 22 (90.51–132.26) 60–90 (No.) (range) 59 (60.06–89.75) 45–60 (No.) (range) 34 (45.82–59.83) <45 (No.) (range) 16 (10.16–44.24) Average eGFR (mL/min/m2) >90 (No.) (range) 61 (90.77–145.93) 60–90 (No.) (range) 61 (61.00–89.88) <60 (No.) (range) 9 (38.24–57.26) ↵a No. of scans refers to scans performed with gadolinium contrast.
- Table 2:
Correlation coefficients and P values for relationships between either ΔGP/T or ΔDN/P and age at last scan, sex, total gadobutrol dose, number of scans performed with gadolinium contrast, lowest eGFR, and average eGFRa
ΔGP/T ΔDN/P r P r P Age at last scan –0.05 .54 0.11 .21 Sex –0.04 .65 0.05 .54 Total gadobutrol dose 0.12 .18 −0.07 .43 No. of scans 0.09 .33 0.12 .18 Lowest eGFR 0.07 0.43 –0.09 0.28 Partial correlation –0.14 .12 0.16 .07 Average eGFR 0.07 0.40 –0.09 0.30 Partial correlation –0.15 .09 0.15 .08 ↵a Pearson coefficients were used for ΔGP/T with lowest and average eGFR, Spearman coefficients were used for every other calculation. Partial correlations were obtained only for ΔGP/T and ΔDN/P versus lowest and average eGFR, while controlling for the other variables.
