Article Figures & Data
Figures
- FIG 1.
Fiber tractography of the MGB from diffusion spectrum imaging: A, Axial. B, Coronal. C, Sagittal. ROIs on the QA map: D, Axial. E, Coronal. F, Sagittal. RhMGN indicates Right MGB; LhMGN, Left MGB.
- FIG 2.
The receiver operating characteristic curves of GFA in the ipsilateral MGB. AUC indicates area under the curve.
Tables
Study Characteristics All Patients (n = 48) Outcome P Value Nonimprovement Group (n = 14) Improvement Group (n = 34) Sex (%) Male 25 (52.1) 7 (28.0) 18 (72.0) .85 Female 23 (47.9) 7 (30.4) 16 (69.6) Hypertension (%) Yes 17 (35.4) 5 (29.4) 12 (70.6) .97 No 31 (64.6) 9 (29.0) 22 (71.0) Type 2 diabetes (%) Yes 10 (20.8) 2 (20.0) 8 (80.0) .47 No 38 (79.2) 12 (31.6) 26 (68.4) Hyperlipidemia (%) Yes 15 (31.2) 4 (26.7) 11 (73.3) .79 No 33 (68.8) 10 (26.3) 23 (69.7) Affected ear (%) Left 29 (60.4) 7 (24.1) 22 (75.9) .34 Right 19 (39.6) 7 (36.8) 12 (63.2) Age (mean ± SD) (yr) 52.3 ± 10.8 53.5 ± 11.7 51.88 ± 10.5 .64 Duration (mean ± SD) (day) 8.9 ± 4.3 10.2 ± 5.0 8.4 ± 3.9 .17 PTA (mean ± SD) (dB) 64.3 ± 25.6 59.5 ± 26.1 75.93 ± 20.7 .10 Audiogram shape (%) Low-frequency 10 (20.8) 1 (10.0) 9 (90.0) .45 High-frequency 11 (22.9) 4 (36.4) 7 (63.6) Flat 14 (29.2) 4 (28.6) 10 (71.4) Profound 13 (27.1) 5 (38.5) 8 (61.5) Hearing loss severity based on PTA (%) Mild (40 dB) 15 (31.3) 1 (6.7) 14 (93.3) .12 Moderate (41–60 dB) 6 (12.5) 3 (50.0) 3 (50.0) Severe (61–90 dB) 18 (37.5) 7 (38.9) 11 (61.1) Profound (≥91 dB) 9 (18.7) 3 (33.3) 6 (66.7) Note:—PTA indicates pure-tone average.
ROIs Parameters Left Side Right Side P Value Superior olivary nucleus QA 0.6725 ± 0.0783 0.6584 ± 0.0910 .55 GFA 0.0902 ± 0.0062 0.0896 ± 0.0081 .64 Inferior colliculus QA 0.6531 ± 0.0800 0.6463 ± 0.0827 .76 GFA 0.0936 ± 0.0052 0.0943 ± 0.0055 .41 Medial geniculate body QA 0.6324 ± 0.0814 0.6327 ± 0.0923 .98 GFA 0.0990 ± 0.0083 0.0968 ± 0.0077 .26 Lateral lemniscus QA 0.6530 ± 0.0815 0.6486 ± 0.0687 .83 GFA 0.0930 ± 0.0088 0.0925 ± 0.0055 .76 Anterior limb of internal capsule QA 0.5717 ± 0.0754 0.5871 ± 0.0754 .45 GFA 0.0853 ± 0.0053 0.0877 ± 0.0044 .08 Posterior limb of internal capsule QA 0.6947 ± 0.0635 0.6907 ± 0.0551 .81 GFA 0.1046 ± 0.0035 0.1046 ± 0.0027 .97 Heschl QA 0.6054 ± 0.0916 0.5792 ± 0.0763 .27 GFA 0.0882 ± 0.0074 0.0831 ± 0.0141 .18 Superior temporal gyrus QA 0.5974 ± 0.0762 0.5941 ± 0.0731 .87 GFA 0.0928 ± 0.0042 0.0912 ± 0.0037 .09 Middle temporal gyrus QA 0.6020 ± 0.0752 0.6064 ± 0.0720 .83 GFA 0.0935 ± 0.0033 0.0929 ± 0.0029 .46 Inferior temporal gyrus QA 0.5594 ± 0.0661 0.5731 ± 0.0686 .47 GFA 0.0849 ± 0.0079 0.0871 ± 0.0069 .06 Anterior corona radiata QA 0.5868 ± 0.0717 0.5711 ± 0.0638 .41 GFA 0.0951 ± 0.0044 0.0937 ± 0.0039 .06 Posterior corona radiata QA 0.7172 ± 0.0814 0.7081 ± 0.0785 .68 GFA 0.1135 ± 0.0071 0.1126 ± 0.0077 .36 Auditory radiation QA 0.6727 ± 0.0783 0.6617 ± 0.0827 .62 GFA 0.1021 ± 0.0061 0.1010 ± 0.0070 .49 Brodmann area 41 QA 0.6350 ± 0.0790 GFA 0.0960 ± 0.0034 Brodmann area 42 QA 0.5483 ± 0.0793 GFA 0.0831 ± 0.0090 ↵a Data are mean ± SD.
- Table 3:
Differences in GFA between patients with unilateral ISSHL (hearing loss ipsilateral side and contralateral side) and healthy subjectsa
ROIs Patients with Unilateral ISSHL Healthy Controls (n = 20) P Value Hearing Loss Ipsilateral Side (n = 48) Hearing Loss Contralateral Side (n = 48) Superior olivary nucleus 0.0898 ± 0.0142 0.0922 ± 0.0163 0.08993 ± 0.0066 .69 Inferior colliculus 0.0951 ± 0.0090 0.0948 ± 0.0067 0.0939 ± 0.0050 .84 Medial geniculate body 0.0963 ± 0.0116 0.0940 ± 0.0098 0.0979 ± 0.0067 .31 Lateral lemniscus 0.0951 ± 0.0084 0.0911 ± 0092 0.0928 ± 0.0061 .07 Anterior limb of internal capsule 0.0816 ± 0.0068 0.0815 ± 0.0071 0.0865 ± 0.0038 .01 Posterior limb of internal capsule 0.0984 ± 0.0073c 0.0997 ± 0.0051b 0.1046 ± 0.0026 .001 Heschl 0.0829 ± 0.0228 0.0842 ± 0.0140 0.0857 ± 0.0078 .83 Superior temporal gyrus 0.0894 ± 0.0070 0.0892 ± 0.0079 0.0920 ± 0.0034 .28 Middle temporal gyrus 0.0920 ± 0.0057 0.0907 ± 0.0061 0.0932 ± 0.0026 .20 Inferior temporal gyrus 0.0850 ± 0.0084 0.0850 ± 0.0071 0.0859 ± 0.0064 .89 Anterior corona radiata 0.0884 ± 0.0075 0.0881 ± 0.0076 0.0941 ± 0.0039 .005 Posterior corona radiata 0.1084 ± 0.0093 0.1079 ± 0.0091 0.1131 ± 0.0071 .08 Auditory radiation 0.0997 ± 0.0089 0.0992 ± 0.0093 0.1015 ± 0.0057 .61 Brodmann area 41 0.0950 ± 0.0074 0.0960 ± 0.0034 .47 Brodmann area 42 0.0812 ± 0.0085 0.0831 ± 0.0090 .41 - Table 4:
Differences in QA between patients with unilateral ISSHL (hearing loss ipsilateral side and contralateral side) and healthy subjectsa
ROIs Patients with Unilateral ISSHL Healthy Controls (n = 20) P Value Hearing Loss Ipsilateral Side (n = 48) Hearing Loss Contralateral Side (n = 48) Superior olivary nucleus 0.5883 ± 0.1047 0.6058 ± 0.0989 0.6578 ± 0.0852 .04 Inferior colliculus 0.6006 ± 0.0844 0.5949 ± 0.0787 0.6463 ± 0.0860 .06 Medial geniculate body 0.5607 ± 0.0949 0.5395 ± 0.0876b 0.6309 ± 0.0883 .001 Lateral lemniscus 0.5986 ± 0.0903c 0.5588 ± 0.1002b 0.6527 ± 0.0714 .001 Anterior limb of internal capsule 0.4798 ± 0.0778b 0.4825 ± 0.0868b 0.5799 ± 0.0646 <.001 Posterior limb of internal capsule 0.6264 ± 0.1115 0.6342 ± 0.0974 0.6895 ± 0.0585 .04 Heschl 0.4931 ± 0.1452 0.5029 ± 0.1011 0.5840 ± 0.0799 .01 Superior temporal gyrus 0.5249 ± 0.0812 0.5266 ± 0.0820 0.5918 ± 0.0759 .005 Middle temporal gyrus 0.5421 ± 0.0732c 0.5345 ± 0.0730c 0.6026 ± 0.0780 .002 Inferior temporal gyrus 0.4969 ± 0.0659 0.4852 ± 0.0914 0.5639 ± 0.0674 .001 Anterior corona radiata 0.5000 ± 0.0691b 0.4985 ± 0.0676b 0.0580 ± 0.0739 <.001 Posterior corona radiata 0.6537 ± 0.0988 0.6484 ± 0.0916 0.7148 ± 0.0837 .02 Auditory radiation 0.5950 ± 0.0848 0.5948 ± 0.0860 0.6607 ± 0.0819 .008 Brodmann area 41 0.5515 ± 0.1041c 0.6303 ± 0.0850 .002 Brodmann area 42 0.4792 ± 0.0756 0.5421 ± 0.0860 .004
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