MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma

C. Jaimes; S. Vajapeyam; D. Brown; P.-C. Kao; C. Ma; L. Greenspan; N. Gupta; L. Goumnerova; P. Bandopahayay; F. Dubois; N.F. Greenwald; T. Zack; O. Shapira; R. Beroukhim; K.L. Ligon; S. Chi; M.W. Kieran; K.D. Wright; T.Y. Poussaint

doi:10.3174/ajnr.A6546

Research ArticlePediatric Neuroimaging

MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma

C. Jaimes, S. Vajapeyam, D. Brown, P.-C. Kao, C. Ma, L. Greenspan, N. Gupta, L. Goumnerova, P. Bandopahayay, F. Dubois, N.F. Greenwald, T. Zack, O. Shapira, R. Beroukhim, K.L. Ligon, S. Chi, M.W. Kieran, K.D. Wright and T.Y. Poussaint

American Journal of Neuroradiology May 2020, DOI: https://doi.org/10.3174/ajnr.A6546

C. Jaimes

aFrom the Departments of Radiology (C.J., S.V., T.Y.P.)

cFetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Division of Newborn Medicine; Boston Children’s Hospital, Boston, Massachusetts

iHarvard Medical School (C.J., S.V., C.M., P.B., F.D., R.B., K.L.L., S.C., K.D.W., T.Y.P.), Boston, Massachusetts

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S. Vajapeyam

aFrom the Departments of Radiology (C.J., S.V., T.Y.P.)

iHarvard Medical School (C.J., S.V., C.M., P.B., F.D., R.B., K.L.L., S.C., K.D.W., T.Y.P.), Boston, Massachusetts

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D. Brown

dTumor Imaging Metrics Core (D.B.), Massachusetts General Hospital, Boston, Massachusetts

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P.-C. Kao

bPediatrics, Division of Oncology (P.-C.K., C.M., L.G., P.B., R.B., S.C., K.D.W.)

eDana Farber Cancer Institute (P.-C.K., C.M., L.G., P.B., F.D., O.S., R.B., K.L.L., S.C., K.D.W.), Boston, Massachusetts

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C. Ma

bPediatrics, Division of Oncology (P.-C.K., C.M., L.G., P.B., R.B., S.C., K.D.W.)

eDana Farber Cancer Institute (P.-C.K., C.M., L.G., P.B., F.D., O.S., R.B., K.L.L., S.C., K.D.W.), Boston, Massachusetts

iHarvard Medical School (C.J., S.V., C.M., P.B., F.D., R.B., K.L.L., S.C., K.D.W., T.Y.P.), Boston, Massachusetts

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L. Greenspan

bPediatrics, Division of Oncology (P.-C.K., C.M., L.G., P.B., R.B., S.C., K.D.W.)

eDana Farber Cancer Institute (P.-C.K., C.M., L.G., P.B., F.D., O.S., R.B., K.L.L., S.C., K.D.W.), Boston, Massachusetts

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N. Gupta

fDepartment of Pediatric Neurosurgery (N.G.), University of California San Francisco Benioff Children’s Hospital, San Francisco, California

jUniversity of California San Francisco School of Medicine (N.G., T.Z.), San Francisco, California

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L. Goumnerova

bPediatrics, Division of Oncology (P.-C.K., C.M., L.G., P.B., R.B., S.C., K.D.W.)

eDana Farber Cancer Institute (P.-C.K., C.M., L.G., P.B., F.D., O.S., R.B., K.L.L., S.C., K.D.W.), Boston, Massachusetts

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P. Bandopahayay

bPediatrics, Division of Oncology (P.-C.K., C.M., L.G., P.B., R.B., S.C., K.D.W.)

eDana Farber Cancer Institute (P.-C.K., C.M., L.G., P.B., F.D., O.S., R.B., K.L.L., S.C., K.D.W.), Boston, Massachusetts

iHarvard Medical School (C.J., S.V., C.M., P.B., F.D., R.B., K.L.L., S.C., K.D.W., T.Y.P.), Boston, Massachusetts

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F. Dubois

eDana Farber Cancer Institute (P.-C.K., C.M., L.G., P.B., F.D., O.S., R.B., K.L.L., S.C., K.D.W.), Boston, Massachusetts

iHarvard Medical School (C.J., S.V., C.M., P.B., F.D., R.B., K.L.L., S.C., K.D.W., T.Y.P.), Boston, Massachusetts

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N.F. Greenwald

kStanford University School of Medicine (N.F.G.), Palo Alto, California

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T. Zack

jUniversity of California San Francisco School of Medicine (N.G., T.Z.), San Francisco, California

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O. Shapira

eDana Farber Cancer Institute (P.-C.K., C.M., L.G., P.B., F.D., O.S., R.B., K.L.L., S.C., K.D.W.), Boston, Massachusetts

lBroad Institute of Massachusetts Institute of Technology and Harvard University (O.S.), Cambridge, Massachusetts.

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R. Beroukhim

bPediatrics, Division of Oncology (P.-C.K., C.M., L.G., P.B., R.B., S.C., K.D.W.)

eDana Farber Cancer Institute (P.-C.K., C.M., L.G., P.B., F.D., O.S., R.B., K.L.L., S.C., K.D.W.), Boston, Massachusetts

iHarvard Medical School (C.J., S.V., C.M., P.B., F.D., R.B., K.L.L., S.C., K.D.W., T.Y.P.), Boston, Massachusetts

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K.L. Ligon

eDana Farber Cancer Institute (P.-C.K., C.M., L.G., P.B., F.D., O.S., R.B., K.L.L., S.C., K.D.W.), Boston, Massachusetts

hDepartment of Pathology (K.L.L.), Brigham and Women’s Hospital, Boston, Massachusetts

iHarvard Medical School (C.J., S.V., C.M., P.B., F.D., R.B., K.L.L., S.C., K.D.W., T.Y.P.), Boston, Massachusetts

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S. Chi

bPediatrics, Division of Oncology (P.-C.K., C.M., L.G., P.B., R.B., S.C., K.D.W.)

eDana Farber Cancer Institute (P.-C.K., C.M., L.G., P.B., F.D., O.S., R.B., K.L.L., S.C., K.D.W.), Boston, Massachusetts

iHarvard Medical School (C.J., S.V., C.M., P.B., F.D., R.B., K.L.L., S.C., K.D.W., T.Y.P.), Boston, Massachusetts

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M.W. Kieran

gClinical Trials Division (M.W.K.), Bristol-Myers-Squibb, New York, New York

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K.D. Wright

bPediatrics, Division of Oncology (P.-C.K., C.M., L.G., P.B., R.B., S.C., K.D.W.)

eDana Farber Cancer Institute (P.-C.K., C.M., L.G., P.B., F.D., O.S., R.B., K.L.L., S.C., K.D.W.), Boston, Massachusetts

iHarvard Medical School (C.J., S.V., C.M., P.B., F.D., R.B., K.L.L., S.C., K.D.W., T.Y.P.), Boston, Massachusetts

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T.Y. Poussaint

aFrom the Departments of Radiology (C.J., S.V., T.Y.P.)

iHarvard Medical School (C.J., S.V., C.M., P.B., F.D., R.B., K.L.L., S.C., K.D.W., T.Y.P.), Boston, Massachusetts

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MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma

American Journal of Neuroradiology May 2020, DOI: 10.3174/ajnr.A6546

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MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma

American Journal of Neuroradiology May 2020, DOI: 10.3174/ajnr.A6546

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