Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

CT Angiography in Evaluating Large-Vessel Occlusion in Acute Anterior Circulation Ischemic Stroke: Factors Associated with Diagnostic Error in Clinical Practice

B.A.C.M. Fasen, R.J.J. Heijboer, F.-J.H. Hulsmans and R.M. Kwee
American Journal of Neuroradiology March 2020, DOI: https://doi.org/10.3174/ajnr.A6469
B.A.C.M. Fasen
aFrom the Department of Radiology, Zuyderland Medical Center, Heerlen/Sittard/Geleen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B.A.C.M. Fasen
R.J.J. Heijboer
aFrom the Department of Radiology, Zuyderland Medical Center, Heerlen/Sittard/Geleen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R.J.J. Heijboer
F.-J.H. Hulsmans
aFrom the Department of Radiology, Zuyderland Medical Center, Heerlen/Sittard/Geleen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for F.-J.H. Hulsmans
R.M. Kwee
aFrom the Department of Radiology, Zuyderland Medical Center, Heerlen/Sittard/Geleen, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R.M. Kwee
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIG 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 1.

    A 75-year-old male patient with acute ischemic stroke. At initial CTA evaluation, occlusion of 1 of the M2 segment branches of the left middle cerebral artery (arrows on all slices) was missed. Consecutive axial CTA slices in a caudocranial direction (A–D) show a contrast filling defect in a branch of the left M2 segment (arrows in C and D). Note that 2 adjacent branches of the left M2 segment show normal contrast filling on all slices (arrowheads).

  • FIG 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 2.

    A 70-year-old male patient with acute ischemic stroke. At initial CTA evaluation, LVO due to a calcified embolus in the M2 segment of the left middle cerebral artery (arrows in CTA image, A; and in a noncontrast head CT image, B) was misinterpreted as clinically irrelevant calcification. Follow-up MR imaging (FLAIR image, C; and diffusion-weighted image, D) 1 day after CTA reveals infarction in the left middle cerebral artery territory (arrows).

Tables

  • Figures
    • View popup
    Table 1:

    Anatomic distribution of LVOs

    Location of LVONo. (%)No. of Missed LVOs at Initial CTA Evaluation (%)
    Distal intracranial carotid artery1 (1.2%)0 (0%)
    Distal intracranial carotid artery and M1 segment10 (11.9%)0 (0%)
    Distal intracranial carotid artery and M2 segment1 (1.2%)0 (0%)
    M1 segment31 (36.9%)3 (17.6%)
    M2 segment40 (47.6%)14 (82.4%)
    A1 segment1 (1.2%)0 (0%)
    A2 segment00 (0%)
    • View popup
    Table 2:

    Variables potentially associated with missing LVO at initial CTA evaluation; results of univariate logistic regression analysisa

    VariablesOdds Ratio (95% CI)P Value
    Interpreter
        Non-neuroradiologists (n = 33) vs neuroradiologists (n = 27)7.14 (1.43–35.57).02
        Senior residents (n = 24) vs neuroradiologists (n = 27)1.79 (0.27–11.71).55
        Senior residents (n = 24) vs non-neuroradiologists (n = 33)0.25 (0.06–1.02).05
    Time of CTA interpretation, on-call hours (n = 40) vs office hours (n = 44)1.89 (0.63–5.70).26
    Reporting of lateralizing symptoms/signs or suspected location of stroke on the request form for CTA; yes (n = 58) vs no (n = 26)0.91 (0.29–2.92).88
    Location of LVO; M2 segment (n = 40) vs distal internal carotid artery and/or M1 segment (n = 42)6.77 (1.79–25.57).005
    • ↵a Nos. in parentheses in column 1 represent the number of CTA scans.

    • View popup
    Table 3:

    Variables potentially associated with missing LVO at initial CTA evaluation; results of multivariate logistic regression analysisa

    VariablesOdds Ratio (95% CI)P Value
    Interpreter
     Non-neuroradiologists (n = 33) vs neuroradiologists (n = 27)5.62 (1.06–29.85).04
     Senior residents (n = 24) vs neuroradiologists (n = 27)1.63 (0.23–11.37).62
     Senior residents (n = 24) vs non-neuroradiologists (n = 33)0.29 (0.07–1.26).10
    Location of LVO; M2 segment (n = 40) vs distal internal carotid artery and/or M1 segment (n = 42)5.69 (1.44–22.57).01
    • ↵a Nos. in parentheses in column 1 represent the number of CTA scans.

PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
CT Angiography in Evaluating Large-Vessel Occlusion in Acute Anterior Circulation Ischemic Stroke: Factors Associated with Diagnostic Error in Clinical Practice
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
B.A.C.M. Fasen, R.J.J. Heijboer, F.-J.H. Hulsmans, R.M. Kwee
CT Angiography in Evaluating Large-Vessel Occlusion in Acute Anterior Circulation Ischemic Stroke: Factors Associated with Diagnostic Error in Clinical Practice
American Journal of Neuroradiology Mar 2020, DOI: 10.3174/ajnr.A6469

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
CT Angiography in Evaluating Large-Vessel Occlusion in Acute Anterior Circulation Ischemic Stroke: Factors Associated with Diagnostic Error in Clinical Practice
B.A.C.M. Fasen, R.J.J. Heijboer, F.-J.H. Hulsmans, R.M. Kwee
American Journal of Neuroradiology Mar 2020, DOI: 10.3174/ajnr.A6469
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Radiologist, Trainee, and Logistical Factors Impacting the Timeliness of CTA Head and Neck Reporting in Stroke Code Activations
  • A Comparative Study of CT Perfusion Postprocessing Tools in Medium/Distal Vessel Occlusion Stroke
  • Perfusion patterns as a tool for emergency stroke diagnosis: differentiating proximal and distal MCA occlusions
  • Artificial Intelligence Efficacy as a Function of Trainee Interpreter Proficiency: Lessons from a Randomized Controlled Trial
  • Development and Validation of Automated Software for the Detection of Large Vessel Occlusion on Noncontrast CT
  • Automated detection of large vessel occlusion using deep learning: a pivotal multicenter study and reader performance study
  • Automated Identification of Thrombectomy Amenable Vessel Occlusion on Computed Tomography Angiography using Deep Learning
  • Automated detection of large vessel occlusion: a multicenter study validating efficacy and proving clinical implications
  • Automated detection of large vessel occlusion using deep learning: a pivotal multicenter clinical trial and reader assessment study
  • Influence of vascular imaging acquisition at local stroke centers on workflows in the drip-n-ship model: a RACECAT post hoc analysis
  • CTA and CTP for Detecting Distal Medium Vessel Occlusions: A Systematic Review and Meta-analysis
  • Influence of vascular imaging acquisition at local stroke centers on workflows in the drip-n-ship model: a RACECAT post hoc analysis
  • Commentary on 'Systematic CT perfusion acquisition in acute stroke increases vascular occlusion detection and thrombectomy rates
  • Diagnostic performance of an algorithm for automated large vessel occlusion detection on CT angiography
  • Automated emergent large vessel occlusion detection by artificial intelligence improves stroke workflow in a hub and spoke stroke system of care
  • Interrater Agreement and Detection Accuracy for Medium-Vessel Occlusions Using Single-Phase and Multiphase CT Angiography
  • Direct Transfer to Angiosuite in Acute Stroke: Why, When, and How?
  • A review of endovascular treatment for medium vessel occlusion stroke
  • The True Potential of Artificial Intelligence for Detection of Large-Vessel Occlusion: The Role of M2 Occlusions
  • Time-to-Maximum of the Tissue Residue Function Improves Diagnostic Performance for Detecting Distal Vessel Occlusions on CT Angiography
  • Missed Medium-Vessel Occlusions on CT Angiography: Make It Easier ... Easily!
  • Reply:
  • Crossref (72)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • A review of endovascular treatment for medium vessel occlusion stroke
    Johanna Maria Ospel, Mayank Goyal
    Journal of NeuroInterventional Surgery 2021 13 7
  • Deep Learning Based Software to Identify Large Vessel Occlusion on Noncontrast Computed Tomography
    Marta Olive-Gadea, Carlos Crespo, Cristina Granes, Maria Hernandez-Perez, Natalia Pérez de la Ossa, Carlos Laredo, Xabier Urra, Juan Carlos Soler, Alexander Soler, Paloma Puyalto, Patricia Cuadras, Cristian Marti, Marc Ribo
    Stroke 2020 51 10
  • Distal Medium Vessel Occlusions Can Be Accurately and Rapidly Detected Using Tmax Maps
    Shalini A. Amukotuwa, Angel Wu, Kevin Zhou, Inna Page, Peter Brotchie, Roland Bammer
    Stroke 2021 52 10
  • Cost-effectiveness of artificial intelligence aided vessel occlusion detection in acute stroke: an early health technology assessment
    Kicky G. van Leeuwen, Frederick J. A. Meijer, Steven Schalekamp, Matthieu J. C. M. Rutten, Ewoud J. van Dijk, Bram van Ginneken, Tim M. Govers, Maarten de Rooij
    Insights into Imaging 2021 12 1
  • Automated emergent large vessel occlusion detection by artificial intelligence improves stroke workflow in a hub and spoke stroke system of care
    Lucas Elijovich, David Dornbos III, Christopher Nickele, Andrei Alexandrov, Violiza Inoa-Acosta, Adam S Arthur, Daniel Hoit
    Journal of NeuroInterventional Surgery 2022 14 7
  • Secondary Medium Vessel Occlusions
    Mayank Goyal, Manon Kappelhof, Rosalie McDonough, Johanna Maria Ospel
    Stroke 2021 52 3
  • Endovascular Treatment of Medium Vessel Occlusion Stroke
    Johanna M. Ospel, Thanh N. Nguyen, Ashutosh P. Jadhav, Marios-Nikos Psychogios, Frédéric Clarençon, Bernard Yan, Mayank Goyal
    Stroke 2024 55 3
  • Diagnostic performance of an algorithm for automated large vessel occlusion detection on CT angiography
    Sven P R Luijten, Lennard Wolff, Martijne H C Duvekot, Pieter-Jan van Doormaal, Walid Moudrous, Henk Kerkhoff, Geert J Lycklama a Nijeholt, Reinoud P H Bokkers, Lonneke S F Yo, Jeannette Hofmeijer, Wim H van Zwam, Adriaan C G M van Es, Diederik W J Dippel, Bob Roozenbeek, Aad van der Lugt
    Journal of NeuroInterventional Surgery 2022 14 8
  • Diagnostic accuracy of automated occlusion detection in CT angiography using e-CTA
    Fatih Seker, Johannes Alex Rolf Pfaff, Yahia Mokli, Anne Berberich, Rafael Namias, Steven Gerry, Simon Nagel, Martin Bendszus, Christian Herweh
    International Journal of Stroke 2022 17 1
  • Interrater Agreement and Detection Accuracy for Medium-Vessel Occlusions Using Single-Phase and Multiphase CT Angiography
    J.M. Ospel, F. Bala, R.V. McDonough, O. Volny, N. Kashani, W. Qiu, B.K. Menon, M. Goyal
    American Journal of Neuroradiology 2022 43 1

More in this TOC Section

  • Rescue Reentry in Carotid Near-Occlusion
  • Contour Neurovascular System: Five Year Follow Up
  • Effect of SARS-CoV2 on Endovascular Thrombectomy
Show more NEUROINTERVENTION

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire