Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort

References

1. 1.↵
   2. Louis DN,
   3. Ohgaki H,
   4. Wiestler OD, et al.

   , eds. WHO Classification of Tumours of the Central Nervous System, 4th ed. Geneva: IARC Press; 2016
2. 2.↵
   2. Louis DN,
   3. Wiestler OD,
   4. Cavenee WK, et al

   . WHO Classification of Tumors of the Central Nervous System. Geneva: IARC Press; 2007
3. 3.↵
   2. Koch A,
   3. Waha A,
   4. Tonn JC, et al

   . Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors. Int J Cancer 2001;93:445–49 doi:10.1002/ijc.1342 pmid:11433413

   CrossRefPubMedWeb of Science
4. 4.↵
   2. Ellison DW,
   3. Onilude OE,
   4. Lindsey JC, et al

   . Beta-catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. J Clin Oncol 2005;23:7951957 doi:10.1200/JCO.2005.01.5479 pmid:16258095

   Abstract/FREE Full Text
5. 5.↵
   2. Waszak SM,
   3. Northcott PA,
   4. Buchhalter I, et al

   . Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. Lancet Oncol 2018;19:785–98 doi:10.1016/S1470-2045(18)30242-0 pmid:29753700

   CrossRefPubMed
6. 6.↵
   2. Baeza N,
   3. Masuoka J,
   4. Kleihues P, et al

   . AXIN1 mutations but not deletions in cerebellar medulloblastomas. Oncogene 2003;22:632–36 doi:10.1038/sj.onc.1206156 pmid:12555076

   CrossRefPubMedWeb of Science
7. 7.↵
   2. Dahmen RP,
   3. Koch A,
   4. Denkhaus D, et al

   . Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas. Cancer Res 2001;61:7039–43 pmid:11585731

   Abstract/FREE Full Text
8. 8.↵
   2. Koch A,
   3. Hrychyk A,
   4. Hartmann W, et al

   . Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas. Int J Cancer 2007;121:284–91 doi:10.1002/ijc.22675 pmid:17373666

   CrossRefPubMedWeb of Science
9. 9.↵
   2. Ellison DW,
   3. Dalton J,
   4. Kocak M, et al

   . Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta Neuropathol 2011;121:381–96 doi:10.1007/s00401-011-0800-8 pmid:21267586

   CrossRefPubMedWeb of Science
10. 10.↵
    2. Kool M,
    3. Korshunov A,
    4. Remke M, et al

    . Molecular subgroups of medulloblastoma. An international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, group 3, and group 4 medulloblastomas. Acta Neuropathol 2012;123:473–84 doi:10.1007/s00401-012-0958-8 pmid:22358457

    CrossRefPubMedWeb of Science
11. 11.↵
    2. Goschzik T,
    3. Schwalbe EC,
    4. Hicks D, et al

    . Prognostic effect of whole chromosomal aberration signatures in standard-risk, non-WNT/non-SHH medulloblastoma: a retrospective, molecular analysis of the HIT-SIOP PNET 4 trial. Lancet Oncol 2018;19:1602–16 doi:10.1016/S1470-2045(18)30532-1 pmid:30392813

    CrossRefPubMed
12. 12.↵
    2. Perreault S,
    3. Ramaswamy V,
    4. Achrol AS, et al

    . MRI surrogates for molecular subgroups of medulloblastoma. AJNR Am J Neuroradiol 2014;35:1263–69 doi:10.3174/ajnr.A3990 pmid:24831600

    Abstract/FREE Full Text
13. 13.↵
    2. Mata-Mbemba D,
    3. Zapotocky M,
    4. Laughlin S, et al

    . MRI characteristics of primary tumors and metastatic lesions in molecular subgroups of pediatric medulloblastoma. a single-center study. AJNR Am J Neuroradiol 2018;39:949–55 doi:10.3174/ajnr.A5578 pmid:29545246

    Abstract/FREE Full Text
14. 14.↵
    2. Patay Z,
    3. DeSain LA,
    4. Hwang SN, et al

    . MR imaging characteristics of wingless-type-subgroup pediatric medulloblastoma. AJNR Am J Neuroradiol 2015;36:2386–93 doi:10.3174/ajnr.A4495 pmid:26338912

    Abstract/FREE Full Text
15. 15.↵
    2. Dasgupta A,
    3. Gupta T,
    4. Pungavkar S, et al

    . Nomograms based on preoperative multiparametric magnetic resonance imaging for prediction of molecular subgrouping in medulloblastoma: results from a radiogenomics study of 111 patients. Neuro Oncol 2019;21:115–24 doi:10.1093/neuonc/noy093 pmid:29846693

    CrossRefPubMed
16. 16.↵
    2. Pietsch T,
    3. Haberler C

    . Update on the integrated histopathological and genetic classification of medulloblastoma: a practical diagnostic guideline. Clin Neuropathol 2016;35:344–52 doi:10.5414/NP300999 pmid:27781424

    CrossRefPubMed
17. 17.↵
    2. Goschzik T,
    3. Zur Mühlen A,
    4. Kristiansen G, et al

    . Molecular stratification of medulloblastoma: comparison of histological and genetic methods to detect Wnt activated tumours. Neuropathol Appl Neurobiol 2015;41:135–44 doi:10.1111/nan.12161 pmid:24894640

    CrossRefPubMed
18. 18.↵
    2. Pietsch T,
    3. Schmidt R,
    4. Remke M, et al

    . Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort. Acta Neuropathol 2014;128:137–49 doi:10.1007/s00401-014-1276-0 pmid:24791927

    CrossRefPubMedWeb of Science
19. 19.↵
    2. Capper D,
    3. Jones DT,
    4. Sill M, et al

    . DNA methylation-based classification of central nervous system tumours. Nature 2018;555:469–74 doi:10.1038/nature26000 pmid:29539639

    CrossRefPubMed
20. 20.↵
    2. Schwalbe EC,
    3. Hicks D,
    4. Rafiee G, et al

    . Minimal methylation classifier (MIMIC). A novel method for derivation and rapid diagnostic detection of disease-associated DNA methylation signatures. Sci Rep 2017;7:13421 doi:10.1038/s41598-017-13644-1 pmid:29044166

    CrossRefPubMed
21. 21.↵
    2. Chang CH,
    3. Housepian EM,
    4. Herbert C

    . An operative staging system and a megavoltage radiotherapeutic technic for cerebellar medulloblastomas. Radiology 1969;93:1351–59 doi:10.1148/93.6.1351 pmid:4983156

    CrossRefPubMedWeb of Science
22. 22.↵
    2. Warmuth-Metz M

    . Imaging and Diagnosis in Pediatric Brain Tumor Studies. Cham: Springer-Verlag International Publishing; 2017:8–12
23. 23.↵
    2. Gibson P,
    3. Tong Y,
    4. Robinson G, et al

    . Subtypes of medulloblastoma have distinct developmental origins. Nature 2010;468:1095–99 doi:10.1038/nature09587 pmid:21150899

    CrossRefPubMedWeb of Science
24. 24.↵
    2. Łastowska M,
    3. Jurkiewicz E,
    4. Trubicka J, et al

    . Contrast enhancement pattern predicts poor survival for patients with non-WNT/SHH medulloblastoma tumours. J Neurooncol 2015;123:65–73 doi:10.1007/s11060-015-1779-0 pmid:25862008

    CrossRefPubMed
25. 25.↵
    2. Teo WY,
    3. Shen J,
    4. Su JM, et al

    . Implications of tumor location on subtypes of medulloblastoma. Pediatr Blood Cancer 2013;60:1408–10 doi:10.1002/pbc.24511 pmid:23512859

    CrossRefPubMed
26. 26.↵
    2. Taylor MD,
    3. Northcott PA,
    4. Korshunov A, et al

    . Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 2012;123:465–72 doi:10.1007/s00401-011-0922-z pmid:22134537

    CrossRefPubMedWeb of Science
27. 27.↵
    2. Northcott PA,
    3. Buchhalter I,
    4. Morrissy AS, et al

    . The whole-genome landscape of medulloblastoma subtypes. Nature 2017;547:311–17 doi:10.1038/nature22973 pmid:28726821

    CrossRefPubMed
28. 28.↵
    2. Schwalbe EC,
    3. Lindsey JC,
    4. Nakjang S, et al

    . Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study. Lancet Oncol 2017;18:958–71 doi:10.1016/S1470-2045(17)30243-7 pmid:28545823

    CrossRefPubMed
29. 29.↵
    2. Cavalli FM,
    3. Remke M,
    4. Rampasek L, et al

    . Intertumoral heterogeneity within medulloblastoma subgroups. Cancer Cell 2017;31:737–54 e6 doi:10.1016/j.ccell.2017.05.005 pmid:28609654

    CrossRefPubMed
30. 30.↵
    2. Zapotocky M,
    3. Mata-Mbemba D,
    4. Sumerauer D, et al

    . Differential patterns of metastatic dissemination across medulloblastoma subgroups. J Neurosurg Pediatr 2018;21:145–52 doi:10.3171/2017.8.PEDS17264 pmid:29219788

    CrossRefPubMed
31. 31.↵
    2. Reisinger D,
    3. Gojo J,
    4. Kasprian G, et al

    . Predisposition of wingless subgroup medulloblastoma for primary tumor hemorrhage. Neurosurgery 2019 May 7. [Epub ahead of print] doi:10.1093/neuros/nyz148 pmid:31065705

    CrossRefPubMed