Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging

The Complex Spine in Children with Spinal Muscular Atrophy: The Transforaminal Approach—A Transformative Technique

R. Towbin, C. Schaefer, R. Kaye, T. Abruzzo and D.J. Aria
American Journal of Neuroradiology July 2019, DOI: https://doi.org/10.3174/ajnr.A6131
R. Towbin
aFrom the Department of Radiology (R.T., C.S., R.K., T.A., D.J.A.), Phoenix Children's Hospital, Phoenix, Arizona
bUniversity of Arizona College of Medicine, Phoenix (R.T., C.S., R.K., D.J.A.), Phoenix, Arizona.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Towbin
C. Schaefer
aFrom the Department of Radiology (R.T., C.S., R.K., T.A., D.J.A.), Phoenix Children's Hospital, Phoenix, Arizona
bUniversity of Arizona College of Medicine, Phoenix (R.T., C.S., R.K., D.J.A.), Phoenix, Arizona.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Schaefer
R. Kaye
aFrom the Department of Radiology (R.T., C.S., R.K., T.A., D.J.A.), Phoenix Children's Hospital, Phoenix, Arizona
bUniversity of Arizona College of Medicine, Phoenix (R.T., C.S., R.K., D.J.A.), Phoenix, Arizona.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Kaye
T. Abruzzo
aFrom the Department of Radiology (R.T., C.S., R.K., T.A., D.J.A.), Phoenix Children's Hospital, Phoenix, Arizona
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T. Abruzzo
D.J. Aria
aFrom the Department of Radiology (R.T., C.S., R.K., T.A., D.J.A.), Phoenix Children's Hospital, Phoenix, Arizona
bUniversity of Arizona College of Medicine, Phoenix (R.T., C.S., R.K., D.J.A.), Phoenix, Arizona.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.J. Aria
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.3174/ajnr.A6131
PubMed 
31296522

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received February 20, 2019
  • Accepted after revision June 17, 2019
  • Published online July 11, 2019.

Article Versions

  • You are currently viewing a Latest version of this article (July 11, 2019 - 06:56).
  • View the most recent version of this article
Copyright & Usage 
© 2019 by American Journal of Neuroradiology

Author Information

  1. R. Towbina,b,
  2. C. Schaefera,b,
  3. R. Kayea,b,
  4. T. Abruzzoa and
  5. D.J. Ariaa,b
  1. aFrom the Department of Radiology (R.T., C.S., R.K., T.A., D.J.A.), Phoenix Children's Hospital, Phoenix, Arizona
  2. bUniversity of Arizona College of Medicine, Phoenix (R.T., C.S., R.K., D.J.A.), Phoenix, Arizona.
  1. Please address correspondence to David J. Aria, MD, MBA, Phoenix Children's Hospital, 1919 E Thomas Rd, Department of Radiology, Phoenix, AZ 85016; e-mail: daria{at}phoenixchildrens.com
View Full Text

Altmetrics

Cited By...

  • 20 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Transforaminal intrathecal delivery of nusinersen for older children and adults with spinal muscular atrophy and complex spinal anatomy: an analysis of 200 consecutive injections
    John J Weaver, Danial K Hallam, Jeffrey Forris Beecham Chick, Sandeep Vaidya, David S Shin, Niranjana Natarajan, Nassim Rad, Joseph Reis, Kevin S H Koo, Giridhar M Shivaram, Ashley Thibodeau, Susan Apkon, Eric James Monroe
    Journal of NeuroInterventional Surgery 2021 13 1
  • Nusinersen by subcutaneous intrathecal catheter for symptomatic spinal muscular atrophy patients with complex spine anatomy
    Vincent J. Carson, Millie Young, Karlla W. Brigatti, Donna L. Robinson, Robert M. Reed, Jihee Sohn, Marco Petrillo, Wildon Farwell, Freeman Miller, Kevin A. Strauss
    Muscle & Nerve 2022 65 1
  • Intrathecal delivery of nusinersen in individuals with complicated spines
    Michael S. Cartwright, Zachary T. Ward, Eric P. White, Thomas G. West
    Muscle & Nerve 2020 62 1
  • Magnetic resonance imaging anatomy and morphometry of lumbar intervertebral foramina to guide safe transforaminal subarachnoid punctures
    Alexander M. Khalaf, Vivek Yedavalli, Tarik F. Massoud
    Clinical Anatomy 2020 33 3
  • Computed‐tomography‐guided transforaminal intrathecal nusinersen injection in adults with spinal muscular atrophy type 2 and severe spinal deformity. Feasibility, safety and radiation exposure considerations
    S. Spiliopoulos, L. Reppas, C. Zompola, L. Palaiodimou, M. Papadopoulou, D. Filippiadis, K. Palialexis, A. Ploussi, E. Efstathopoulos, G. Tsivgoulis, E. Brountzos
    European Journal of Neurology 2020 27 7
  • Imaging anatomy of the vertebral canal for trans‐sacral hiatus puncture of the lumbar cistern
    Austin Trinh, Syed S. Hashmi, Tarik F. Massoud
    Clinical Anatomy 2021 34 3
  • A Systematic Review of Procedural Complications from Transforaminal Lumbar Puncture for Intrathecal Nusinersen Administration in Patients with Spinal Muscular Atrophy
    A. Grayev, M. Schoepp, A. Kuner
    American Journal of Neuroradiology 2021 42 5
  • Transforaminal lumbar puncture for intrathecal access: Case series with literature review and comparison to other techniques
    Vinodkumar Velayudhan, Suraj Patel, Andrew Danziger, Arcadi Grigorian, Stephen Waite, Aslan Efendizade
    Journal of Clinical Neuroscience 2020 72
  • Nusinersen for Patients With Spinal Muscular Atrophy: 1415 Doses via an Interdisciplinary Institutional Approach
    Elena Madan, Sabrina Carrié, Carolina Donado, Kimberly Lobo, Michelle Souris, Regina Laine, Elizabeth Beers, Laura Cornelissen, Basil T. Darras, Anjali Koka, Bobbie Riley, Pradeep Dinakar, Scellig Stone, Brian Snyder, Robert J. Graham, Horacio Padua, Navil Sethna, Charles Berde
    Pediatric Neurology 2022 132
  • Best Practices for the Orthopaedic Care of Children with Spinal Muscular Atrophy: A Consensus Statement from the European Neuromuscular Centre Standard of Care Orthopaedic Working Group
    Michael Vitale, Benjamin Roye, Zachary Bloom, Jennifer A. Kunes, Hiroko Matsumoto, David Roye, David Farrington, Jack Flynn, Matthew Halanski, Carol Hasler, Lotfi Miladi, Susana Quijano-Roy, Christopher Reilly, Paul Sponseller, Muharrem Yazici, Brian Snyder
    Journal of the Pediatric Orthopaedic Society of North America 2022 4 1
  • Intrathecal catheter and port placement for nusinersen infusion in children with spinal muscular atrophy and spinal fusion
    Kumar K. Shashi, Scellig S. D. Stone, Charles B. Berde, Horacio M. Padua
    Pediatric Radiology 2021 51 13
  • Transforaminal lumbar puncture for spinal anesthesia or novel drug administration: a technique combining C-arm fluoroscopy and ultrasound
    Charles Berde, Anna Formanek, Asif Khan, Carlos Rafael Camelo, Anjali Koka, Bobbie L Riley, Horacio Padua
    Regional Anesthesia & Pain Medicine 2022 47 6
  • Cone-beam computed tomography guided nusinersen administrations in adult spinal muscular atrophy patients with challenging access: a single- center experience
    Vladka Salapura, Ziga Snoj, Lea Leonardis, Blaz Koritnik, Viktorija Kostadinova
    Radiology and Oncology 2022 56 3
  • Computed tomography-guided transforaminal lumbar puncture using local anesthesia and a straight 22-gauge spinal needle for intrathecal nusinersen in adults: Findings in 77 procedures
    Mougnyan Cox, Kofi-Buaku Atsina, Preethi Ramchand, Jonathan Ji, Neda Sedora-Roman, Bryan Pukenas
    Interventional Neuroradiology 2022 28 3
  • Nusinersen Administration in Spinal Muscular Atrophy Patients with Severe Scoliosis: Interlaminar Approaches at the Lumbar Level
    Joo Young Song, Hyun Su Kim, Se-Jun Park, Jiwon Lee, Jeehun Lee
    Annals of Child Neurology 2020 28 2
  • Innovative Computed Tomography–Assisted Intrathecal Nusinersen Injection in a Pediatric Patient
    Reheman Palati, Jishou lv, Jing Yu, Lei He, Yan Sun
    Clinical Pediatrics 2024 63 6
  • Interventions for Spinal Muscular Atrophy
    Janki Desai, Richard B. Towbin, Carrie M. Schaefer, Alexander J. Towbin
    Applied Radiology 2023
  • Lumbar Transforaminal Injections of Nusinersen in Spinal Muscular Atrophy Patients
    Eric J. Monroe
    Neuroimaging Clinics of North America 2025 35 1
  • Needleless inhaled anesthesia with sevoflurane: Advantages of a simplified approach for children with spinal muscular atrophy undergoing intrathecal administration of nusinersen
    Annalisa Salerno, Enzo Picconi, Orazio Genovese, Marco Piastra, Silvia M. Pulitanò, Federica Tosi, Aldo Mancino, Marika Pane, Roberto De Sanctis, Debora Carlini, Eugenio M. Mercuri, Giorgio Conti
    Pediatric Anesthesia 2023 33 4
  • Surgical Access for Intrathecal Therapy in Spinal Muscular Atrophy with Spinal Fusion: Long-Term Outcomes of Lumbar Laminectomy
    Tomasz Potaczek, Sławomir Duda, Jakub Adamczyk
    Journal of Clinical Medicine 2025 14 12
PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Complex Spine in Children with Spinal Muscular Atrophy: The Transforaminal Approach—A Transformative Technique
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
R. Towbin, C. Schaefer, R. Kaye, T. Abruzzo, D.J. Aria
The Complex Spine in Children with Spinal Muscular Atrophy: The Transforaminal Approach—A Transformative Technique
American Journal of Neuroradiology Jul 2019, DOI: 10.3174/ajnr.A6131

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
The Complex Spine in Children with Spinal Muscular Atrophy: The Transforaminal Approach—A Transformative Technique
R. Towbin, C. Schaefer, R. Kaye, T. Abruzzo, D.J. Aria
American Journal of Neuroradiology Jul 2019, DOI: 10.3174/ajnr.A6131
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Transforaminal lumbar puncture for spinal anesthesia or novel drug administration: a technique combining C-arm fluoroscopy and ultrasound
  • A Systematic Review of Procedural Complications from Transforaminal Lumbar Puncture for Intrathecal Nusinersen Administration in Patients with Spinal Muscular Atrophy
  • Transforaminal intrathecal delivery of nusinersen for older children and adults with spinal muscular atrophy and complex spinal anatomy: an analysis of 200 consecutive injections
  • Crossref (20)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Transforaminal intrathecal delivery of nusinersen for older children and adults with spinal muscular atrophy and complex spinal anatomy: an analysis of 200 consecutive injections
    John J Weaver, Danial K Hallam, Jeffrey Forris Beecham Chick, Sandeep Vaidya, David S Shin, Niranjana Natarajan, Nassim Rad, Joseph Reis, Kevin S H Koo, Giridhar M Shivaram, Ashley Thibodeau, Susan Apkon, Eric James Monroe
    Journal of NeuroInterventional Surgery 2021 13 1
  • Nusinersen by subcutaneous intrathecal catheter for symptomatic spinal muscular atrophy patients with complex spine anatomy
    Vincent J. Carson, Millie Young, Karlla W. Brigatti, Donna L. Robinson, Robert M. Reed, Jihee Sohn, Marco Petrillo, Wildon Farwell, Freeman Miller, Kevin A. Strauss
    Muscle & Nerve 2022 65 1
  • Intrathecal delivery of nusinersen in individuals with complicated spines
    Michael S. Cartwright, Zachary T. Ward, Eric P. White, Thomas G. West
    Muscle & Nerve 2020 62 1
  • Magnetic resonance imaging anatomy and morphometry of lumbar intervertebral foramina to guide safe transforaminal subarachnoid punctures
    Alexander M. Khalaf, Vivek Yedavalli, Tarik F. Massoud
    Clinical Anatomy 2020 33 3
  • Computed‐tomography‐guided transforaminal intrathecal nusinersen injection in adults with spinal muscular atrophy type 2 and severe spinal deformity. Feasibility, safety and radiation exposure considerations
    S. Spiliopoulos, L. Reppas, C. Zompola, L. Palaiodimou, M. Papadopoulou, D. Filippiadis, K. Palialexis, A. Ploussi, E. Efstathopoulos, G. Tsivgoulis, E. Brountzos
    European Journal of Neurology 2020 27 7
  • Imaging anatomy of the vertebral canal for trans‐sacral hiatus puncture of the lumbar cistern
    Austin Trinh, Syed S. Hashmi, Tarik F. Massoud
    Clinical Anatomy 2021 34 3
  • A Systematic Review of Procedural Complications from Transforaminal Lumbar Puncture for Intrathecal Nusinersen Administration in Patients with Spinal Muscular Atrophy
    A. Grayev, M. Schoepp, A. Kuner
    American Journal of Neuroradiology 2021 42 5
  • Transforaminal lumbar puncture for intrathecal access: Case series with literature review and comparison to other techniques
    Vinodkumar Velayudhan, Suraj Patel, Andrew Danziger, Arcadi Grigorian, Stephen Waite, Aslan Efendizade
    Journal of Clinical Neuroscience 2020 72
  • Nusinersen for Patients With Spinal Muscular Atrophy: 1415 Doses via an Interdisciplinary Institutional Approach
    Elena Madan, Sabrina Carrié, Carolina Donado, Kimberly Lobo, Michelle Souris, Regina Laine, Elizabeth Beers, Laura Cornelissen, Basil T. Darras, Anjali Koka, Bobbie Riley, Pradeep Dinakar, Scellig Stone, Brian Snyder, Robert J. Graham, Horacio Padua, Navil Sethna, Charles Berde
    Pediatric Neurology 2022 132
  • Best Practices for the Orthopaedic Care of Children with Spinal Muscular Atrophy: A Consensus Statement from the European Neuromuscular Centre Standard of Care Orthopaedic Working Group
    Michael Vitale, Benjamin Roye, Zachary Bloom, Jennifer A. Kunes, Hiroko Matsumoto, David Roye, David Farrington, Jack Flynn, Matthew Halanski, Carol Hasler, Lotfi Miladi, Susana Quijano-Roy, Christopher Reilly, Paul Sponseller, Muharrem Yazici, Brian Snyder
    Journal of the Pediatric Orthopaedic Society of North America 2022 4 1

More in this TOC Section

Pediatric Neuroimaging

  • FRACTURE MR in Congenital Vertebral Anomalies
  • Neuroimaging Delineation and Progression of SLSMD
  • fetal brain development of 10 weeks gestation
Show more Pediatric Neuroimaging

Spine Imaging and Spine Image-Guided Interventions

  • Characteristics of SIH Type I Culprit Lesions
  • Management Outcomes For VO Spine Biopsy
  • Cone Beam CT Myelography
Show more Spine Imaging and Spine Image-Guided Interventions

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire