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Research ArticlePediatric Neuroimaging

Functional Connectivity Associated with Health-Related Quality of Life in Children with Focal Epilepsy

H. Nawani, M.L. Smith, A.L. Wheeler and E. Widjaja
American Journal of Neuroradiology June 2019, DOI: https://doi.org/10.3174/ajnr.A6106
H. Nawani
aFrom Neurosciences and Mental Health (H.N., M.L.S., A.L.W., E.W.)
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M.L. Smith
aFrom Neurosciences and Mental Health (H.N., M.L.S., A.L.W., E.W.)
dDepartments of Psychology (M.L.S.)
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A.L. Wheeler
aFrom Neurosciences and Mental Health (H.N., M.L.S., A.L.W., E.W.)
ePhysiology (A.L.W.), University of Toronto, Toronto, Ontario, Canada.
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E. Widjaja
aFrom Neurosciences and Mental Health (H.N., M.L.S., A.L.W., E.W.)
bDiagnostic Imaging (E.W.)
cDivision of Neurology (E.W.), Hospital for Sick Children, Toronto, Ontario, Canada
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REFERENCES

  1. 1.↵
    1. Biswal BB,
    2. Van Kylen J,
    3. Hyde JS
    . Simultaneous assessment of flow and BOLD signals in resting-state functional connectivity maps. NMR Biomed 1997;10:165–70 pmid:9430343
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Wang J,
    2. Zuo X,
    3. He Y
    . Graph-based network analysis of resting-state functional MRI. Front Syst Neurosci 2010;4:16 doi:10.3389/fnsys.2010.00016 pmid:20589099
    CrossRefPubMed
  3. 3.↵
    1. Rubinov M,
    2. Sporns O
    . Complex network measures of brain connectivity: uses and interpretations. Neuroimage 2010;52:1059–69 doi:10.1016/j.neuroimage.2009.10.003 pmid:19819337
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Spencer SS
    . Neural networks in human epilepsy: evidence of and implications for treatment. Epilepsia 2002;43:219–27 doi:10.1046/j.1528-1157.2002.26901.x pmid:11906505
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Rubinger L,
    2. Chan C,
    3. D'Arco F, et al
    . Change in presurgical diagnostic imaging evaluation affects subsequent pediatric epilepsy surgery outcome. Epilepsia 2016;57:32–40 doi:10.1111/epi.13229 pmid:26715387
    CrossRefPubMed
  6. 6.↵
    1. Vaessen MJ,
    2. Braakman HM,
    3. Heerink JS, et al
    . Abnormal modular organization of functional networks in cognitively impaired children with frontal lobe epilepsy. Cereb Cortex 2013;23:1997–2006 doi:10.1093/cercor/bhs186 pmid:22772649
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Ofer I,
    2. Jacobs J,
    3. Jaiser N, et al
    . Cognitive and behavioral comorbidities in Rolandic epilepsy and their relation with default mode network's functional connectivity and organization. Epilepsy Behav 2018;78:179–86 doi:10.1016/j.yebeh.2017.10.013 pmid:29103838
    CrossRefPubMed
  8. 8.↵
    1. Paldino MJ,
    2. Golriz F,
    3. Chapieski ML, et al
    . Brain network architecture and global intelligence in children with focal epilepsy. AJNR Am J Neuroradiol 2017;38:349–56 doi:10.3174/ajnr.A4975 pmid:27737853
    Abstract/FREE Full Text
  9. 9.↵
    1. Spieth LE,
    2. Harris CV
    . Assessment of health-related quality of life in children and adolescents: an integrative review. J Pediatr Psychol 1996;21:175–93 doi:10.1093/jpepsy/21.2.175 pmid:8920152
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Austin JK,
    2. Risinger MW,
    3. Beckett LA
    . Correlates of behavior problems in children with epilepsy. Epilepsia 1992;33:1115–22 doi:10.1111/j.1528-1157.1992.tb01768.x pmid:1464273
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Williams J,
    2. Steel C,
    3. Sharp GB, et al
    . Anxiety in children with epilepsy. Epilepsy Behav 2003;4:729–32 doi:10.1016/j.yebeh.2003.08.032 pmid:14698708
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Rodenburg R,
    2. Stams GJ,
    3. Meijer AM, et al
    . Psychopathology in children with epilepsy: a meta-analysis. J Pediatr Psychol 2005;30:453–68 doi:10.1093/jpepsy/jsi071 pmid:16055484
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Ferro MA
    . Risk factors for health-related quality of life in children with epilepsy: a meta-analysis. Epilepsia 2014;55:1722–31 doi:10.1111/epi.12772 pmid:25243908
    CrossRefPubMed
  14. 14.↵
    1. Conway L,
    2. Smith ML,
    3. Ferro MA, et al
    . Predictors of health-related quality of life in children with intractable epilepsy. Epilepsia 2016;57:1256–64 doi:10.1111/epi.13441 pmid:27350597
    CrossRefPubMed
  15. 15.↵
    1. Sabaz M,
    2. Cairns DR,
    3. Lawson JA, et al
    . The health-related quality of life of children with refractory epilepsy: a comparison of those with and without intellectual disability. Epilepsia 2001;42:621–28 doi:10.1046/j.1528-1157.2001.25200.x pmid:11380569
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Sabaz M,
    2. Cairns DR,
    3. Lawson JA, et al
    . Validation of a new quality of life measure for children with epilepsy. Epilepsia 2000;41:765–74 doi:10.1111/j.1528-1157.2000.tb00240.x pmid:10840411
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Sabaz M,
    2. Lawson JA,
    3. Cairns DR, et al
    . Validation of the quality of life in childhood epilepsy questionnaire in American epilepsy patients. Epilepsy Behav 2003;4:680–91 doi:10.1016/j.yebeh.2003.08.012 pmid:14698702
    CrossRefPubMed
  18. 18.↵
    1. Smith SM
    . Fast robust automated brain extraction. Hum Brain Mapp 2002;17:143–55 doi:10.1002/hbm.10062 pmid:12391568
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Jenkinson M,
    2. Bannister P,
    3. Brady M, et al
    . Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002;17:825–41 doi:10.1006/nimg.2002.1132 pmid:12377157
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Fonov V,
    2. Evans AC,
    3. Botteron K, et al
    ; Brain Development Cooperative Group. Unbiased average age-appropriate atlases for pediatric studies. Neuroimage 2011;54:313–27 doi:10.1016/j.neuroimage.2010.07.033 pmid:20656036
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Zhang Y,
    2. Brady M,
    3. Smith S
    . Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 2001;20:45–57 doi:10.1109/42.906424 pmid:11293691
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Shen X,
    2. Tokoglu F,
    3. Papademetris X, et al
    . Groupwise whole-brain parcellation from resting-state fMRI data for network node identification. Neuroimage 2013;82:403–15 doi:10.1016/j.neuroimage.2013.05.081 pmid:23747961
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. van den Heuvel MP,
    2. de Lange SC,
    3. Zalesky A, et al
    . Proportional thresholding in resting-state fMRI functional connectivity networks and consequences for patient-control connectome studies: issues and recommendations. Neuroimage 2017;152:437–49 doi:10.1016/j.neuroimage.2017.02.005 pmid:28167349
    CrossRefPubMed
  24. 24.↵
    1. Ren P,
    2. Heffner KL,
    3. Jacobs A, et al
    . Acute affective reactivity and quality of life in older adults with amnestic mild cognitive impairment: a functional MRI study. Am J Geriatr Psychiatry 2017;25:1225–33 doi:10.1016/j.jagp.2017.06.019 pmid:28755988
    CrossRefPubMed
  25. 25.↵
    1. Greenberg T,
    2. Bertocci MA,
    3. Chase HW, et al
    . Mediation by anxiety of the relationship between amygdala activity during emotion processing and poor quality of life in young adults. Transl Psychiatry 2017;7:e1178 doi:10.1038/tp.2017.127 pmid:28742077
    CrossRefPubMed
  26. 26.↵
    1. Watts DJ,
    2. Strogatz SH
    . Collective dynamics of 'small-world' networks. Nature 1998;393:440–42 doi:10.1038/30918 pmid:9623998
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Takeda K,
    2. Matsuda H,
    3. Miyamoto Y, et al
    . Structural brain network analysis of children with localization-related epilepsy. Brain Dev 2017;39:678–86 doi:10.1016/j.braindev.2017.04.010 pmid:28487114
    CrossRefPubMed
  28. 28.↵
    1. Sethi M,
    2. Pedersen M,
    3. Jackson GD
    . Polymicrogyric cortex may predispose to seizures via abnormal network topology: an fMRI connectomics study. Epilepsia 2016;57:e64–68 doi:10.1111/epi.13304 pmid:26763051
    CrossRefPubMed
  29. 29.↵
    1. Vaughan DN,
    2. Rayner G,
    3. Tailby C, et al
    . MRI-negative temporal lobe epilepsy: a network disorder of neocortical connectivity. Neurology 2016;87:1934–42 doi:10.1212/WNL.0000000000003289 pmid:27694267
    Abstract/FREE Full Text
  30. 30.↵
    1. Kundu P,
    2. Benson BE,
    3. Rosen D, et al
    . The integration of functional brain activity from adolescence to adulthood. J Neurosci 2018;38:3559–70 doi:10.1523/JNEUROSCI.1864-17.2018 pmid:29487126
    Abstract/FREE Full Text
  31. 31.↵
    1. Gu S,
    2. Satterthwaite TD,
    3. Medaglia JD, et al
    . Emergence of system roles in normative neurodevelopment. Proc Natl Acad Sci U S A 2015;112:13681–86 doi:10.1073/pnas.1502829112 pmid:26483477
    Abstract/FREE Full Text
  32. 32.↵
    1. Hallquist MN,
    2. Hillary FG
    . Graph theory approaches to functional network organization in brain disorders: a new critique for a brave new small-world. Netw Neurosci 2019;3:1–26 doi:10.1162/netn_a_00054 pmid:30793071
    CrossRefPubMed
  33. 33.↵
    1. Buckner RL,
    2. Andrews-Hanna JR,
    3. Schacter DL
    . The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci 2008;1124:1–38 doi:10.1196/annals.1440.011 pmid:18400922
    CrossRefPubMedWeb of Science
  34. 34.↵
    1. Hwang JW,
    2. Xin SC,
    3. Ou YM, et al
    . Enhanced default mode network connectivity with ventral striatum in subthreshold depression individuals. J Psychiatr Res 2016;76:111–20 doi:10.1016/j.jpsychires.2016.02.005 pmid:26922247
    CrossRefPubMed
  35. 35.↵
    1. Widjaja E,
    2. Zamyadi M,
    3. Raybaud C, et al
    . Disrupted global and regional structural networks and subnetworks in children with localization-related epilepsy. AJNR Am J Neuroradiol 2015;36:1362–68 doi:10.3174/ajnr.A4265 pmid:25742984
    Abstract/FREE Full Text
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H. Nawani, M.L. Smith, A.L. Wheeler, E. Widjaja
Functional Connectivity Associated with Health-Related Quality of Life in Children with Focal Epilepsy
American Journal of Neuroradiology Jun 2019, DOI: 10.3174/ajnr.A6106

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Functional Connectivity Associated with Health-Related Quality of Life in Children with Focal Epilepsy
H. Nawani, M.L. Smith, A.L. Wheeler, E. Widjaja
American Journal of Neuroradiology Jun 2019, DOI: 10.3174/ajnr.A6106
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