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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticlePediatric Neuroimaging
Open Access

MRI Abnormalities Predominate in the Bottom Part of the Sulcus with Type II Focal Cortical Dysplasia: A Quantitative Study

Z. Liu, W. Hu, Z. Sun, X. Wang, L. Liu, X. Shao, K. Zhang, Y. Ma and J. Zhang
American Journal of Neuroradiology December 2018, DOI: https://doi.org/10.3174/ajnr.A5919
Z. Liu
aFrom the Departments of Neurosurgery (Z.L., X.W., K.Z., J.Z.)
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W. Hu
cBeijing Neurosurgical Institute (W.H., J.Z.), Capital Medical University, Beijing, China
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Z. Sun
dDepartment of Neurosurgery (Z.S.), Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
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X. Wang
aFrom the Departments of Neurosurgery (Z.L., X.W., K.Z., J.Z.)
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L. Liu
eDepartment of Pathology (L.L.)
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X. Shao
bNeurology (X.S.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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K. Zhang
aFrom the Departments of Neurosurgery (Z.L., X.W., K.Z., J.Z.)
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Y. Ma
fNeurosurgery (Y.M.), Beijing Fengtai Hospital, Beijing, China.
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J. Zhang
aFrom the Departments of Neurosurgery (Z.L., X.W., K.Z., J.Z.)
cBeijing Neurosurgical Institute (W.H., J.Z.), Capital Medical University, Beijing, China
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    Fig 1.

    Dysplastic sulcus labeling. A, Dysplastic sulcus with an abnormality of gray-white matter junction blurring (coronal). B, Dysplastic sulcus with an abnormality of cortical FLAIR hyperintensity (coronal).

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    Fig 2.

    Schematic diagram of the divisions of the sulcus and the types of spatial distribution of abnormal findings on MR imaging. A, Line a is tangential to the interior border of the gray matter in the sulcus bottom, and line b is parallel to line a, intersecting the bottom point of the sulcus. Gray matter interior and exterior to line b is defined as the bottom and the nonbottom parts, respectively. If one considered gray-white matter junction blurring, for example, spatial distribution types 1 (B), 2 (C), and 3 (D) are defined as the abnormalities located in the bottom part, both the bottom and nonbottom parts, and the nonbottom part, respectively.

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    Fig 3.

    Abnormal findings on MR imaging detected by conventional visual analysis and postprocessing techniques. MRI+ indicates positive by conventional visual analysis; Subtle, negative by conventional visual analysis but positive by postprocessing; MRI−, negative by postprocessing.

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    Fig 4.

    Statistical data of the 3 spatial distribution types of abnormalities on MR imaging. A, Gray-white matter junction blurring. B, Cortical FLAIR hyperintensity.

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    Fig 5.

    Comparisons between the bottom and nonbottom parts in patients with a type 2 abnormality distribution. A, Comparison of z-values derived from the junction image (designed to measure gray-white matter junction blurring) of MAP. B, Comparison of standardized volumes of abnormalities (z > 3.5) in the junction image. C, Comparison of z-values derived from the nFSI image (designed to measure cortical FLAIR hyperintensity). D, Comparison of standardized volumes of abnormalities (z > 3) in the nFSI image.

Tables

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  • Frequencies of abnormal findings on MRI measured by quantitative methods

    All (n = 58)IIa (n = 32)IIb (n = 26)P (IIa vs IIb)
    Gray-white matter junction blurring38 (65.52%)17 (53.13%)21 (80.77%).029
    Cortical FLAIR hyperintensity26 (44.83%)8 (25%)18 (69.23%).001
    Cortical thickening4 (6.90%)2 (6.25%)2 (7.69%)>.999
    Abnormal gyrus or sulcus7 (12.07%)5 (15.63%)2 (7.69%).614
    Transmantle sign13 (22.41%)0 (0%)13 (100%)<.001
    Normal findings16 (27.59%)13 (40.63%)3 (11.54%).015
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MRI Abnormalities Predominate in the Bottom Part of the Sulcus with Type II Focal Cortical Dysplasia: A Quantitative Study
Z. Liu, W. Hu, Z. Sun, X. Wang, L. Liu, X. Shao, K. Zhang, Y. Ma, J. Zhang
American Journal of Neuroradiology Dec 2018, DOI: 10.3174/ajnr.A5919
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Z. Liu, W. Hu, Z. Sun, X. Wang, L. Liu, X. Shao, K. Zhang, Y. Ma, J. Zhang
MRI Abnormalities Predominate in the Bottom Part of the Sulcus with Type II Focal Cortical Dysplasia: A Quantitative Study
American Journal of Neuroradiology Dec 2018, DOI: 10.3174/ajnr.A5919

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