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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleSpine Imaging and Spine Image-Guided Interventions

Percutaneous CT-Guided Biopsies of the Cervical Spine: Technique, Histopathologic and Microbiologic Yield, and Safety at a Single Academic Institution

E.L. Wiesner, T.J. Hillen, J. Long and J.W. Jennings
American Journal of Neuroradiology April 2018, DOI: https://doi.org/10.3174/ajnr.A5603
E.L. Wiesner
aFrom the Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
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T.J. Hillen
aFrom the Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
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J. Long
aFrom the Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
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J.W. Jennings
aFrom the Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
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    Fig 1.

    CT-guided cervical spine biopsies were performed using anterolateral, posterolateral, posterior, or lateral approaches. A, CT angiogram of the neck flipped vertically to depict prone positioning for a posterolateral- or posterior-approach cervical spine biopsy. The black arrow demonstrates a posterolateral-approach biopsy of the vertebral body or disc. The dashed black arrow demonstrates a directly posterior approach to a lesion in the spinous process. B, CT angiogram of the neck rotated to depict decubitus positioning for a lateral-approach biopsy to the vertebral body (dashed black arrow). Note that the course of the biopsy needle is between the carotid artery (black oval) and vertebral artery (white oval). C, CT angiogram of the neck with the patient in a supine position for an anterolateral-approach cervical spine biopsy. The needle (dashed white arrow) passes between the intubated trachea (white asterisk), nasogastric tube/esophagus (solid white arrow), carotid artery (black oval), and vertebral artery (white oval).

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    Fig 2.

    A 70-year-old woman with a history of lung cancer and a new right C5 mass extending into the adjacent soft tissues. A, Axial T1 fat-suppressed postcontrast MR image with a large right C5 mass (black asterisk) extending into the adjacent soft tissues and vertebral canal. B, Intraprocedural CT angiogram with the patient in a left lateral decubitus position shows the mass (white asterisk) and adjacent vascular structures (vertebral artery, white arrow; common carotid artery, white oval; jugular vein, black oval). C, Intraprocedural CT image with the patient in the left lateral decubitus position demonstrates the biopsy using a coaxial soft-tissue biopsy needle passing between vascular structures (vertebral artery, white arrow; common carotid artery, white oval; jugular vein, black oval) into the mass (white asterisk) using a lateral approach. The surgical pathology result was metastatic lung adenocarcinoma.

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    Fig 3.

    A 55-year-old woman with right neck and arm pain. A, Axial T2-weighted MR image with a large right C2 vertebral mass (black asterisk) surrounding the vertebral artery (white arrow). B, Intraprocedural CT angiogram soft-tissue-windowed image with the patient prone shows the mass (white asterisk) and adjacent vascular structures (deep cervical vein, white oval; vertebral artery, black oval). C, Intraprocedural CT bone-windowed image with the patient prone demonstrates the bone-access needle (white arrow) in the posterolateral right lamina of C2 and a soft-tissue biopsy needle (dashed white arrow) placed coaxially into the mass (white asterisk), using a posterolateral approach. The surgical pathology result was chordoma.

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    Fig 4.

    A 51-year-old woman with prior discectomy and interbody fusion. A, Sagittal T1 fat-suppressed postcontrast MR image with evidence of osteomyelitis at C7 (black asterisk), prevertebral inflammation, and epidural abscess (white arrow). Intraprocedural oblique axial (B) and oblique sagittal (C) CT reconstructed images during the biopsy procedure show the biopsy needle placed from a posterolateral approach, through the right C7 pedicle (white arrow) into the vertebral body (black asterisk) and subsequently the C6–C7 disc space (black arrow). Microbiology grew Staphylococcus aureus, and pathology showed osteomyelitis.

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    Table 1:

    Biopsy needles used for 34 bone lesion biopsiesa

    Biopsy NeedleBone Lesion Samples
    Bonopty 14/15 (AprioMed)8
    Arrow OnControl 11/13 (Teleflex)12
    Arrow OnControl 12/14 (Teleflex)5
    Achieve 16 (CareFusion)5
    Bard 14 (Bard Peripheral Vascular)5
    Bard 16 (Bard Peripheral Vascular)1
    Tru-Cut 18 (CareFusion)3
    Tru-Cut 20 (CareFusion)1
    • ↵a Six procedures used both bone and soft-tissue biopsy needle systems for 40 total needle systems used.

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    Table 2:

    Biopsy needles used for 39 infection biopsiesa

    Biopsy NeedleSoft-Tissue Samples
    Bonopty 14/15 (AprioMed)16
    Arrow OnControl 11/13 (Teleflex)20
    Arrow OnControl 12/14 (Teleflex)3
    Achieve 14 (CareFusion)1
    Achieve 16 (CareFusion)1
    Achieve 18 (CareFusion)1
    Temno Evolution 18 (CareFusion)2
    Tru-Cut 16 (CareFusion)1
    Tru-Cut 20 (CareFusion)1
    • ↵a Seven procedures used both bone and soft-tissue biopsy needle systems, 9 procedures used only soft-tissue needle systems, and 23 procedures used only bone biopsy needle systems for 46 total needle systems used.

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    Table 3:

    Histopathologic results of CT-guided cervical bone biopsies for primary tumors or metastatic disease

    Malignant (n = 24 cases)
        Myeloma4
        NSCLC/adenocarcinoma4
        Osteoid osteoma3
        Chordoma2
        Giant cell tumor2
        Indeterminate (abnormal)2
    Metastatic carcinoma
        Unknown primary2
        Epithelioid hemangioendothelioma1
    Metastatic carcinoma
        Breast primary1
    Metastatic papillary
        Thyroid carcinoma1
        Aneurysmal bone cyst focal1
        Eosinophilic granuloma1
    Benign (n = 10 cases)
        Normala6
        Marrow fibrosis1
        Chronic inflammation1
        Micrococcus species1
        Osteomyelitis1
    • Note:—NSCLC indicates non-small-cell lung carcinoma.

    • ↵a Normal means biopsy demonstrating normal bone seen on histopathology.

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Cite this article
E.L. Wiesner, T.J. Hillen, J. Long, J.W. Jennings
Percutaneous CT-Guided Biopsies of the Cervical Spine: Technique, Histopathologic and Microbiologic Yield, and Safety at a Single Academic Institution
American Journal of Neuroradiology Apr 2018, DOI: 10.3174/ajnr.A5603

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Percutaneous CT-Guided Biopsies of the Cervical Spine: Technique, Histopathologic and Microbiologic Yield, and Safety at a Single Academic Institution
E.L. Wiesner, T.J. Hillen, J. Long, J.W. Jennings
American Journal of Neuroradiology Apr 2018, DOI: 10.3174/ajnr.A5603
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