Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging

Characteristic MR Imaging Findings of the Neonatal Brain in RASopathies

M.N. Cizmeci, M. Lequin, K.D. Lichtenbelt, D. Chitayat, P. Kannu, A.G. James, F. Groenendaal, E. Chakkarapani, S. Blaser and L.S. de Vries
American Journal of Neuroradiology April 2018, DOI: https://doi.org/10.3174/ajnr.A5611
M.N. Cizmeci
aFrom the Departments of Neonatology (M.N.C., F.G., L.S.d.V.)
cBrain Center Rudolf Magnus (M.N.C., F.G., L.S.d.V.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.N. Cizmeci
M. Lequin
bPediatric Radiology (M.L.), Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Lequin
K.D. Lichtenbelt
dDepartment of Medical Genetics (K.D.L.), University Medical Center Utrecht, Utrecht, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K.D. Lichtenbelt
D. Chitayat
eDivisions of Clinical and Metabolic Genetics (D.C., P.K.)
hDepartments of Obstetrics and Gynecology, Laboratory Medicine, Pathobiology and Molecular Genetics (D.C.), University of Toronto, Toronto, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Chitayat
P. Kannu
eDivisions of Clinical and Metabolic Genetics (D.C., P.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Kannu
A.G. James
fNeonatology (A.G.J.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.G. James
F. Groenendaal
aFrom the Departments of Neonatology (M.N.C., F.G., L.S.d.V.)
cBrain Center Rudolf Magnus (M.N.C., F.G., L.S.d.V.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for F. Groenendaal
E. Chakkarapani
iDivision of Neonatology (E.C.), School of Clinical Sciences, St Michael's Hospital, University of Bristol, Bristol, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Chakkarapani
S. Blaser
gNeuroradiology (S.B.), Department of Diagnostic Imaging, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Blaser
L.S. de Vries
aFrom the Departments of Neonatology (M.N.C., F.G., L.S.d.V.)
cBrain Center Rudolf Magnus (M.N.C., F.G., L.S.d.V.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L.S. de Vries
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.3174/ajnr.A5611
PubMed 
29622558

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received October 30, 2017
  • Accepted after revision February 5, 2018
  • Published online April 5, 2018.

Article Versions

  • You are currently viewing a Latest version of this article (April 5, 2018 - 07:41).
  • View the most recent version of this article
Copyright & Usage 
© 2018 by American Journal of Neuroradiology

Author Information

  1. M.N. Cizmecia,c,
  2. M. Lequinb,
  3. K.D. Lichtenbeltd,
  4. D. Chitayate,h,
  5. P. Kannue,
  6. A.G. Jamesf,
  7. F. Groenendaala,c,
  8. E. Chakkarapanii,
  9. S. Blaserg and
  10. L.S. de Vriesa,c
  1. aFrom the Departments of Neonatology (M.N.C., F.G., L.S.d.V.)
  2. bPediatric Radiology (M.L.), Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands
  3. cBrain Center Rudolf Magnus (M.N.C., F.G., L.S.d.V.)
  4. dDepartment of Medical Genetics (K.D.L.), University Medical Center Utrecht, Utrecht, the Netherlands
  5. eDivisions of Clinical and Metabolic Genetics (D.C., P.K.)
  6. fNeonatology (A.G.J.)
  7. gNeuroradiology (S.B.), Department of Diagnostic Imaging, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, Canada
  8. hDepartments of Obstetrics and Gynecology, Laboratory Medicine, Pathobiology and Molecular Genetics (D.C.), University of Toronto, Toronto, Canada
  9. iDivision of Neonatology (E.C.), School of Clinical Sciences, St Michael's Hospital, University of Bristol, Bristol, UK.
  1. Please address correspondence to Linda S. de Vries, MD, PhD, Department Neonatology, KE 04.123.1, Lundlaan 6, 3584 EA Utrecht, the Netherlands; e-mail: l.s.devries{at}umcutrecht.nl
View Full Text

Altmetrics

Cited By...

  • 17 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The sixth international RASopathies symposium: Precision medicine—From promise to practice
    Karen W. Gripp, Lisa Schill, Lisa Schoyer, Beth Stronach, Anton M. Bennett, Susan Blaser, Amanda Brown, Rebecca Burdine, Emma Burkitt‐Wright, Pau Castel, Sandra Darilek, Alwyn Dias, Tuesdi Dyer, Michelle Ellis, Gregg Erickson, Bruce D. Gelb, Tamar Green, Andrea Gross, Alan Ho, James Lloyd Holder, Shin‐Ichi Inoue, Angie C. Jelin, Annie Kennedy, Richard Klein, Maria I. Kontaridis, Pilar Magoulas, Darryl B. McConnell, Frank McCormick, Benjamin G. Neel, Carlos E. Prada, Katherine A. Rauen, Amy Roberts, Pablo Rodriguez‐Viciana, Neal Rosen, Gavin Rumbaugh, Anna Sablina, Maja Solman, Marco Tartaglia, Angelica Thomas, William C. Timmer, Kartik Venkatachalam, Karin S. Walsh, Pamela L. Wolters, Jae‐Sung Yi, Martin Zenker, Nancy Ratner
    American Journal of Medical Genetics Part A 2020 182 3
  • The brain's kryptonite: Overview of punctate white matter lesions in neonates
    Annie L.A. Nguyen, Yang Ding, Sabrina Suffren, Irène Londono, David Luck, Gregory A. Lodygensky
    International Journal of Developmental Neuroscience 2019 77 1
  • External hydrocephalus as a prenatal feature of noonan syndrome
    Gioia Mastromoro, Alessandro De Luca, Enrica Marchionni, Antonella Spagnuolo, Flavia Ventriglia, Lucia Manganaro, Antonio Pizzuti
    Annals of Human Genetics 2021 85 6
  • Central nervous system involvement in individuals withRASopathies
    K. Nicole Weaver, Karen W. Gripp
    American Journal of Medical Genetics Part C: Seminars in Medical Genetics 2022 190 4
  • Sinus pericranii, skull defects, and structural brain anomalies inTRAF7‐related disorder
    Andrea Accogli, Marcello Scala, Marco Pavanello, Mariasavina Severino, Carlo Gandolfo, Patrizia De Marco, Francesco Musacchia, Annalaura Torella, Michele Pinelli, Vincenzo Nigro, Valeria Capra
    Birth Defects Research 2020 112 14
  • ADA2 deficiency in a patient with Noonan syndrome‐like disorder with loose anagen hair: The co‐occurrence of two rare syndromes
    Ozlem Akgun‐Dogan, Pelin O. Simsek‐Kiper, Ekim Taskiran, Christina Lissewski, Julia Brinkmann, Denny Schanze, Rahşan Göçmen, Deniz Cagdas, Yelda Bilginer, Gülen E. Utine, Martin Zenker, Seza Ozen, İlhan Tezcan, Mehmet Alikasifoglu, Koray Boduroğlu
    American Journal of Medical Genetics Part A 2019 179 12
  • Brain structural changes in patients with cardio-facio-cutaneous syndrome: effects of BRAF gene mutation and epilepsy on brain development. A case–control study by quantitative magnetic resonance imaging
    Rosalinda Calandrelli, Fabio Pilato, Marco Panfili, Domenica Battaglia, Maria Luigia Gambardella, Cesare Colosimo
    Neuroradiology 2022 64 1
  • Mutation and Phenotypic Spectrum of Patients With RASopathies
    Meenakshi Lallar, Sunita Bijarnia-Mahay, I. C. Verma, Kaushik Mandal, Ratna Dua Puri
    Indian Pediatrics 2021 58 1
  • Noonan syndrome: Neuroimaging findings and morphometric analysis of the cranium base and posterior fossa in children
    Ercan Ayaz, Ruken Yıldırım, Canan Çelebi, Servan Ozalkak
    Journal of Neuroimaging 2023 33 2
  • Detailed prenatal and postnatal MRI findings and clinical analysis of RAF1 in Noonan syndrome
    Kjell Helenius, Riitta Parkkola, Anita Arola, Ville Peltola, Maria K. Haanpää
    European Journal of Medical Genetics 2022 65 11
  • Maternal SLE and brachytelephalangic chondrodysplasia punctata in a patient with unrelated de novo RAF1 and SIX2 variants
    Ebba Alkhunaizi, Sharon Unger, Patrick Shannon, Gen Nishimura, Susan Blaser, David Chitayat
    American Journal of Medical Genetics Part A 2020 182 7
  • New Insights Into the Spectrum of RASopathies: Clinical and Genetic Data in a Cohort of 121 Spanish Patients
    Ana Isabel Sánchez Barbero, Irene Valenzuela, Paula Fernández‐Alvarez, Élida Vazquez, Anna Maria Cueto‐Gonzalez, Amaia Lasa‐Aranzasti, Laura Trujillano, Bárbara Masotto, Elena García Arumí, Eduardo F. Tizzano
    American Journal of Medical Genetics Part A 2025 197 3
  • Pediatric Neuroradiology
    Ana Filipa Geraldo, Andrea Rossi, Mariasavina Severino
    2021
  • Prenatal Opioid Exposure Is Associated with Punctate White Matter Lesions in Term Newborns
    Stephanie L. Merhar, Carla M. Bann, Nicole Mack, Jamie E. Newman, Catherine Limperopoulos, Namasivayam Ambalavanan, Jonathan M. Davis, Sara B. DeMauro, Scott A. Lorch, Deanne E. Wilson-Costello, Myriam Peralta-Carcelan, Lindsay M. Parlberg, Brenda B. Poindexter, Kushal Kapse, Beth M. Kline-Fath, Jonathan G. Murnick
    The Journal of Pediatrics 2025 284
  • Second Trimester Ultrasound Diagnosis of External Hydrocephalus in Two Fetuses with Noonan Syndrome—Case Report Series
    Tibor Elekes, Aniko Ladanyi, Eva Pap, Janos Szabo, Anett Illes, Nora Gullai, Szabolcs Varbiro
    Journal of Clinical Medicine 2025 14 11
  • Social Communication in Ras Pathway Disorders: A Comprehensive Review From Genetics to Behavior in Neurofibromatosis Type 1 and Noonan Syndrome
    Monica Siqueiros-Sanchez, Yaffa Serur, Chloe A. McGhee, Taylor F. Smith, Tamar Green
    Biological Psychiatry 2025 97 5
  • The RASopathies
    Alana M. McNeill, Dante J. Rogers, Elizabeth I. Pierpont
    2024
Next
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Characteristic MR Imaging Findings of the Neonatal Brain in RASopathies
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
M.N. Cizmeci, M. Lequin, K.D. Lichtenbelt, D. Chitayat, P. Kannu, A.G. James, F. Groenendaal, E. Chakkarapani, S. Blaser, L.S. de Vries
Characteristic MR Imaging Findings of the Neonatal Brain in RASopathies
American Journal of Neuroradiology Apr 2018, DOI: 10.3174/ajnr.A5611

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Characteristic MR Imaging Findings of the Neonatal Brain in RASopathies
M.N. Cizmeci, M. Lequin, K.D. Lichtenbelt, D. Chitayat, P. Kannu, A.G. James, F. Groenendaal, E. Chakkarapani, S. Blaser, L.S. de Vries
American Journal of Neuroradiology Apr 2018, DOI: 10.3174/ajnr.A5611
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref (17)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The sixth international RASopathies symposium: Precision medicine—From promise to practice
    Karen W. Gripp, Lisa Schill, Lisa Schoyer, Beth Stronach, Anton M. Bennett, Susan Blaser, Amanda Brown, Rebecca Burdine, Emma Burkitt‐Wright, Pau Castel, Sandra Darilek, Alwyn Dias, Tuesdi Dyer, Michelle Ellis, Gregg Erickson, Bruce D. Gelb, Tamar Green, Andrea Gross, Alan Ho, James Lloyd Holder, Shin‐Ichi Inoue, Angie C. Jelin, Annie Kennedy, Richard Klein, Maria I. Kontaridis, Pilar Magoulas, Darryl B. McConnell, Frank McCormick, Benjamin G. Neel, Carlos E. Prada, Katherine A. Rauen, Amy Roberts, Pablo Rodriguez‐Viciana, Neal Rosen, Gavin Rumbaugh, Anna Sablina, Maja Solman, Marco Tartaglia, Angelica Thomas, William C. Timmer, Kartik Venkatachalam, Karin S. Walsh, Pamela L. Wolters, Jae‐Sung Yi, Martin Zenker, Nancy Ratner
    American Journal of Medical Genetics Part A 2020 182 3
  • The brain's kryptonite: Overview of punctate white matter lesions in neonates
    Annie L.A. Nguyen, Yang Ding, Sabrina Suffren, Irène Londono, David Luck, Gregory A. Lodygensky
    International Journal of Developmental Neuroscience 2019 77 1
  • External hydrocephalus as a prenatal feature of noonan syndrome
    Gioia Mastromoro, Alessandro De Luca, Enrica Marchionni, Antonella Spagnuolo, Flavia Ventriglia, Lucia Manganaro, Antonio Pizzuti
    Annals of Human Genetics 2021 85 6
  • Central nervous system involvement in individuals withRASopathies
    K. Nicole Weaver, Karen W. Gripp
    American Journal of Medical Genetics Part C: Seminars in Medical Genetics 2022 190 4
  • Sinus pericranii, skull defects, and structural brain anomalies inTRAF7‐related disorder
    Andrea Accogli, Marcello Scala, Marco Pavanello, Mariasavina Severino, Carlo Gandolfo, Patrizia De Marco, Francesco Musacchia, Annalaura Torella, Michele Pinelli, Vincenzo Nigro, Valeria Capra
    Birth Defects Research 2020 112 14
  • ADA2 deficiency in a patient with Noonan syndrome‐like disorder with loose anagen hair: The co‐occurrence of two rare syndromes
    Ozlem Akgun‐Dogan, Pelin O. Simsek‐Kiper, Ekim Taskiran, Christina Lissewski, Julia Brinkmann, Denny Schanze, Rahşan Göçmen, Deniz Cagdas, Yelda Bilginer, Gülen E. Utine, Martin Zenker, Seza Ozen, İlhan Tezcan, Mehmet Alikasifoglu, Koray Boduroğlu
    American Journal of Medical Genetics Part A 2019 179 12
  • Brain structural changes in patients with cardio-facio-cutaneous syndrome: effects of BRAF gene mutation and epilepsy on brain development. A case–control study by quantitative magnetic resonance imaging
    Rosalinda Calandrelli, Fabio Pilato, Marco Panfili, Domenica Battaglia, Maria Luigia Gambardella, Cesare Colosimo
    Neuroradiology 2022 64 1
  • Mutation and Phenotypic Spectrum of Patients With RASopathies
    Meenakshi Lallar, Sunita Bijarnia-Mahay, I. C. Verma, Kaushik Mandal, Ratna Dua Puri
    Indian Pediatrics 2021 58 1
  • Noonan syndrome: Neuroimaging findings and morphometric analysis of the cranium base and posterior fossa in children
    Ercan Ayaz, Ruken Yıldırım, Canan Çelebi, Servan Ozalkak
    Journal of Neuroimaging 2023 33 2
  • Detailed prenatal and postnatal MRI findings and clinical analysis of RAF1 in Noonan syndrome
    Kjell Helenius, Riitta Parkkola, Anita Arola, Ville Peltola, Maria K. Haanpää
    European Journal of Medical Genetics 2022 65 11

More in this TOC Section

  • Comparing MRI Perfusion in Pediatric Brain Tumors
  • Frontal Paraventricular Cysts
  • Sodium MRI in Pediatric Brain Tumors
Show more PEDIATRIC NEUROIMAGING

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire