Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention
Open Access

Leukoaraiosis Attenuates Diagnostic Accuracy of Large-Vessel Occlusion Scales

Y. Mayasi, R.P. Goddeau, M. Moonis, B. Silver, A.H. Jun-O'Connell, A.S. Puri and N. Henninger
American Journal of Neuroradiology November 2017, DOI: https://doi.org/10.3174/ajnr.A5473
Y. Mayasi
aFrom the Department of Neurology (Y.M., R.P.G., M.M., B.S., A.H.J.-O., N.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Y. Mayasi
R.P. Goddeau Jr
aFrom the Department of Neurology (Y.M., R.P.G., M.M., B.S., A.H.J.-O., N.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R.P. Goddeau Jr
M. Moonis
aFrom the Department of Neurology (Y.M., R.P.G., M.M., B.S., A.H.J.-O., N.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Moonis
B. Silver
aFrom the Department of Neurology (Y.M., R.P.G., M.M., B.S., A.H.J.-O., N.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Silver
A.H. Jun-O'Connell
aFrom the Department of Neurology (Y.M., R.P.G., M.M., B.S., A.H.J.-O., N.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.H. Jun-O'Connell
A.S. Puri
bDepartment of Radiology, Division of Neurointerventional Radiology (A.S.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.S. Puri
N. Henninger
aFrom the Department of Neurology (Y.M., R.P.G., M.M., B.S., A.H.J.-O., N.H.)
cDepartment of Psychiatry (N.H), University of Massachusetts Medical School, Worcester, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Henninger
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Goyal M,
    2. Hill MD,
    3. Saver JL, et al
    . Challenges and opportunities of endovascular stroke therapy. Ann Neurol 2016;79:11–17 doi:10.1002/ana.24528 pmid:26395431
    CrossRefPubMed
  2. 2.↵
    1. Zhao H,
    2. Coote S,
    3. Pesavento L, et al
    . Large vessel occlusion scales increase delivery to endovascular centers without excessive harm from misclassifications. Stroke 2017;48:568–73 doi:10.1161/STROKEAHA.116.016056 pmid:28232591
    Abstract/FREE Full Text
  3. 3.↵
    1. Skagen K,
    2. Skjelland M,
    3. Russell D, et al
    . Large-vessel occlusion stroke: effect of recanalization on outcome depends on the National Institutes of Health Stroke Scale score. J Stroke Cerebrovasc Dis 2015;24:1532–39 doi:10.1016/j.jstrokecerebrovasdis.2015.03.020 pmid:25922156
    CrossRefPubMed
  4. 4.↵
    1. Saver JL,
    2. Goyal M,
    3. van der Lugt A, et al
    ; HERMES Collaborators. Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis. JAMA 2016;316:1279–88 doi:10.1001/jama.2016.13647 pmid:27673305
    CrossRefPubMed
  5. 5.↵
    1. Chen CJ,
    2. Ding D,
    3. Starke RM, et al
    . Endovascular vs medical management of acute ischemic stroke. Neurology 2015;85:1980–90 doi:10.1212/WNL.0000000000002176 pmid:26537058
    Abstract/FREE Full Text
  6. 6.↵
    1. Teleb MS,
    2. Ver Hage A,
    3. Carter J, et al
    . Stroke vision, aphasia, neglect (VAN) assessment-a novel emergent large vessel occlusion screening tool: pilot study and comparison with current clinical severity indices. J Neurointerv Surg 2017;9:122–26 doi:10.1136/neurintsurg-2015-012131 pmid:26891627
    Abstract/FREE Full Text
  7. 7.↵
    1. Singer OC,
    2. Dvorak F,
    3. du Mesnil de Rochemont R, et al
    . A simple 3-item stroke scale: comparison with the National Institutes of Health Stroke Scale and prediction of middle cerebral artery occlusion. Stroke 2005;36:773–76 doi:10.1161/01.STR.0000157591.61322.df pmid:15731478
    Abstract/FREE Full Text
  8. 8.↵
    1. Pérez de la Ossa N,
    2. Carrera D,
    3. Gorchs M, et al
    . Design and validation of a prehospital stroke scale to predict large arterial occlusion: the rapid arterial occlusion evaluation scale. Stroke 2014;45:87–91 doi:10.1161/STROKEAHA.113.003071 pmid:24281224
    Abstract/FREE Full Text
  9. 9.↵
    1. Lima FO,
    2. Silva GS,
    3. Furie KL, et al
    . Field assessment stroke triage for emergency destination: a simple and accurate prehospital scale to detect large vessel occlusion strokes. Stroke 2016;47:1997–2002 doi:10.1161/STROKEAHA.116.013301 pmid:27364531
    Abstract/FREE Full Text
  10. 10.↵
    1. Katz BS,
    2. McMullan JT,
    3. Sucharew H, et al
    . Design and validation of a pre-hospital scale to predict stroke severity: Cincinnati Prehospital Stroke Severity Scale. Stroke 2015;46:1508–12 doi:10.1161/STROKEAHA.115.008804 pmid:25899242
    Abstract/FREE Full Text
  11. 11.↵
    1. Scheitz JF,
    2. Abdul-Rahim AH,
    3. MacIsaac RL, et al
    . Clinical selection strategies to identify ischemic stroke patients with large anterior vessel occlusion: results from SITS-ISTR (Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Registry). Stroke 2017;48:290–97 doi:10.1161/STROKEAHA.116.014431 pmid:28087804
    Abstract/FREE Full Text
  12. 12.↵
    1. Kasner SE
    . Clinical interpretation and use of stroke scales. Lancet Neurol 2006;5:603–12 doi:10.1016/S1474-4422(06)70495-1 pmid:16781990
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Mohamad NF,
    2. Hastrup S,
    3. Rasmussen M, et al
    . Bypassing primary stroke centre reduces delay and improves outcomes for patients with large vessel occlusion. Eur Stroke J 2016;1:85–92 doi:10.1177/2396987316647857
    CrossRef
  14. 14.↵
    1. Helenius J,
    2. Henninger N
    . Leukoaraiosis burden significantly modulates the association between infarct volume and National Institutes of Health Stroke Scale in ischemic stroke. Stroke 2015;46:1857–63 doi:10.1161/STROKEAHA.115.009258 pmid:25999386
    Abstract/FREE Full Text
  15. 15.↵
    1. Helenius J,
    2. Goddeau RP Jr.,
    3. Moonis M, et al
    . Impact of leukoaraiosis burden on hemispheric lateralization of the National Institutes of Health Stroke Scale deficit in acute ischemic stroke. Stroke 2016;47:24–30 doi:10.1161/STROKEAHA.115.011771 pmid:26556825
    Abstract/FREE Full Text
  16. 16.↵
    1. Onteddu SR,
    2. Goddeau RP Jr.,
    3. Minaeian A, et al
    . Clinical impact of leukoaraiosis burden and chronological age on neurological deficit recovery and 90-day outcome after minor ischemic stroke. J Neurol Sci 2015;359:418–23 doi:10.1016/j.jns.2015.10.005 pmid:26476774
    CrossRefPubMed
  17. 17.↵
    1. Zhang J,
    2. Puri AS,
    3. Khan MA, et al
    . Leukoaraiosis predicts a poor 90-day outcome after endovascular stroke therapy. AJNR Am J Neuroradiol 2014;35:2070–75 doi:10.3174/ajnr.A4029 pmid:24994827
    Abstract/FREE Full Text
  18. 18.↵
    1. Henninger N,
    2. Goddeau RP Jr.,
    3. Karmarkar A, et al
    . Atrial fibrillation is associated with a worse 90-day outcome than other cardioembolic stroke subtypes. Stroke 2016;47:1486–92 doi:10.1161/STROKEAHA.116.012865 pmid:27217503
    Abstract/FREE Full Text
  19. 19.↵
    1. Henninger N,
    2. Lin E,
    3. Baker SP, et al
    . Leukoaraiosis predicts poor 90-day outcome after acute large cerebral artery occlusion. Cerebrovasc Dis 2012;33:525–31 doi:10.1159/000337335 pmid:22538962
    CrossRefPubMed
  20. 20.↵
    1. Wardlaw JM,
    2. Smith EE,
    3. Biessels GJ, et al
    ; STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 2013;12:822–38 doi:10.1016/S1474-4422(13)70124-8 pmid:23867200
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Rinaldo L,
    2. Brinjikji W,
    3. Rabinstein AA
    . Transfer to high-volume centers associated with reduced mortality after endovascular treatment of acute stroke. Stroke 2017;48:1316–21 doi:10.1161/STROKEAHA.116.016360 pmid:28336679
    Abstract/FREE Full Text
  22. 22.↵
    1. Southerland AM,
    2. Johnston KC,
    3. Molina CA, et al
    . Suspected large vessel occlusion: should emergency medical services transport to the nearest primary stroke center or bypass to a comprehensive stroke center with endovascular capabilities? Stroke 2016;47:1965–67 doi:10.1161/STROKEAHA.115.011149 pmid:26896433
    FREE Full Text
  23. 23.↵
    1. Nogueira RG,
    2. Silva GS,
    3. Lima FO, et al
    . The FAST-ED App: a smartphone platform for the field triage of patients with stroke. Stroke 2017;48:1278–84 doi:10.1161/STROKEAHA.116.016026 pmid:28411260
    Abstract/FREE Full Text
  24. 24.↵
    1. Akbik F,
    2. Hirsch JA,
    3. Chandra RV, et al
    . Telestroke-the promise and the challenge, Part one: growth and current practice. J Neurointerv Surg 2017;9:357–60 doi:10.1136/neurintsurg-2016-012291 pmid:26984868
    Abstract/FREE Full Text
  25. 25.↵
    1. Srivastava PV,
    2. Sudhan P,
    3. Khurana D, et al
    . Telestroke a viable option to improve stroke care in India. Int J Stroke 2014;9(suppl A100):133–34 doi:10.1111/ijs.12326 pmid:25042038
    CrossRefPubMed
  26. 26.↵
    1. Schwamm LH,
    2. Rosenthal ES,
    3. Hirshberg A, et al
    . Virtual TeleStroke support for the emergency department evaluation of acute stroke. Acad Emerg Med 2004;11:1193–97 doi:10.1111/j.1553-2712.2004.tb00704.x pmid:15528584
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Liang JW,
    2. Stein L,
    3. Wilson N, et al
    . Timing of vessel imaging for suspected large vessel occlusions does not affect groin puncture time in transfer patients with stroke. J Neurointerv Surg 2017 Jan 24. [Epub ahead of print] doi:10.1136/neurintsurg-2016-012854 pmid:28119375
    CrossRefPubMed
  28. 28.↵
    1. Khan MA,
    2. Baird GL,
    3. Miller D, et al
    . Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort. J Neurointerv Surg 2017;9:727–31 doi:10.1136/neurintsurg-2016-012427 pmid:27402857
    Abstract/FREE Full Text
  29. 29.↵
    1. Heldner MR,
    2. Hsieh K,
    3. Broeg-Morvay A, et al
    . Clinical prediction of large vessel occlusion in anterior circulation stroke: mission impossible? J Neurol 2016;263:1633–40 doi:10.1007/s00415-016-8180-6 pmid:27272907
    CrossRefPubMed
  30. 30.↵
    1. Hastrup S,
    2. Damgaard D,
    3. Johnsen SP, et al
    . Prehospital acute stroke severity scale to predict large artery occlusion: design and comparison with other scales. Stroke 2016;47:1772–76 doi:10.1161/STROKEAHA.115.012482 pmid:27272487
    Abstract/FREE Full Text
Next
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Leukoaraiosis Attenuates Diagnostic Accuracy of Large-Vessel Occlusion Scales
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Y. Mayasi, R.P. Goddeau, M. Moonis, B. Silver, A.H. Jun-O'Connell, A.S. Puri, N. Henninger
Leukoaraiosis Attenuates Diagnostic Accuracy of Large-Vessel Occlusion Scales
American Journal of Neuroradiology Nov 2017, DOI: 10.3174/ajnr.A5473

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Leukoaraiosis Attenuates Diagnostic Accuracy of Large-Vessel Occlusion Scales
Y. Mayasi, R.P. Goddeau, M. Moonis, B. Silver, A.H. Jun-O'Connell, A.S. Puri, N. Henninger
American Journal of Neuroradiology Nov 2017, DOI: 10.3174/ajnr.A5473
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Paramedic utilization of Vision, Aphasia, Neglect (VAN) stroke severity scale in the prehospital setting predicts emergent large vessel occlusion stroke
  • Relationship of white matter lesion severity with early and late outcomes after mechanical thrombectomy for large vessel stroke
  • Crossref (6)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Endovascular Treatment of Anterior Circulation Large Vessel Occlusion in the Elderly
    Mahesh V. Jayaraman, Ryan A. McTaggart
    Frontiers in Neurology 2018 8
  • Relationship of white matter lesion severity with early and late outcomes after mechanical thrombectomy for large vessel stroke
    Zimbul Albo, Jose Marino, Muhammad Nagy, Dilip K Jayaraman, Muhammad U Azeem, Ajit S Puri, Nils Henninger
    Journal of NeuroInterventional Surgery 2021 13 1
  • Paramedic utilization of Vision, Aphasia, Neglect (VAN) stroke severity scale in the prehospital setting predicts emergent large vessel occlusion stroke
    Lee Birnbaum, David Wampler, Arash Shadman, Mateja de Leonni Stanonik, Michele Patterson, Emily Kidd, Jeanette Tovar, Ashley Garza, Bonnie Blanchard, Lara Slesnick, Adam Blanchette, David Miramontes
    Journal of NeuroInterventional Surgery 2021 13 6
  • Clinical Policy: Critical Issues in the Management of Adult Patients Presenting to the Emergency Department With Acute Ischemic Stroke
    Bruce M. Lo, Christopher R. Carpenter, Stephen Ducey, Michael Gottlieb, Amy Kaji, Deborah B. Diercks, Deborah B. Diercks, Stephen J. Wolf, John D. Anderson, Richard Byyny, Christopher R. Carpenter, Benjamin Friedman, Seth R. Gemme, Charles J. Gerardo, Steven A. Godwin, Sigrid A. Hahn, Benjamin W. Hatten, Jason S. Haukoos, Amy Kaji, Heemun Kwok, Bruce M. Lo, Sharon E. Mace, Maggie Moran, Susan B. Promes, Kaushal H. Shah, Richard D. Shih, Scott M. Silvers, Andrea Slivinski, Michael D. Smith, Molly E.W. Thiessen, Christian A. Tomaszewski, Stacy Trent, Jonathan H. Valente, Stephen P. Wall, Lauren M. Westafer, Yanling Yu, Stephen V. Cantrill, John T. Finnell, Travis Schulz, Kaeli Vandertulip
    Annals of Emergency Medicine 2023 82 2
  • Pre-existing White Matter Hyperintensity Lesion Burden and Diagnostic Certainty of Transient Ischemic Attack
    Muhammad Nagy, Muhammad U. Azeem, Youssef Soliman, Sahil A. Nawab, Adalia H. Jun-O'Connell, Richard P. Goddeau, Majaz Moonis, Brian Silver, Nils Henninger
    Journal of Stroke and Cerebrovascular Diseases 2019 28 4
  • Diagnostic accuracy of 3-item stroke scale for detection of cerebral large vessel occlusion: A systematic review and meta-analysis
    Hamed Zarei, Mandana Ebrahimzade, Mohsen Hajiqasemi, Mahrokh Janmohamadi, Hamzah Adel Ramawad, Mohammad Haji Aghajani, Mahmoud Yousefifard
    The American Journal of Emergency Medicine 2024 83

More in this TOC Section

  • A Retrospective Study in Tentorial DAVFs
  • Proximal Protection Devices for Carotid Stenting
  • Rescue Reentry in Carotid Near-Occlusion
Show more NEUROINTERVENTION

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire